Optimizing Group Transfer Catalysis by Copper Complex with Redox-Active Ligand in an Entatic State

• Published in: iScience Vol. 23; no. 3; p. 100955
• Main Authors: Ren, Yufeng, Forté, Jeremy, Cheaib, Khaled, Vanthuyne, Nicolas, Fensterbank, Louis, Vezin, Hervé, Orio, Maylis, Blanchard, Sébastien, Desage-El Murr, Marine
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 27.03.2020; Elsevier
• Subjects: Catalysis; Chemical Sciences; Inorganic Chemistry; Molecular Inorganic Chemistry; or physical chemistry; Theoretical and; Inorganic Chemistry; Molecular Inorganic Chemistry; Catalysis; generation; models; reactivity; MACO; E-POM; radicals; oxidation; POLE 1; POLE 2; galactose-oxidase; cu; site; aziridination; metal-complexes

Metalloenzymes use earth-abundant non-noble metals to perform high-fidelity transformations in the biological world. To ensure chemical efficiency, metalloenzymes have acquired evolutionary reactivity-enhancing tools. Among these, the entatic state model states that a strongly distorted geometry ind...