Identification and prospective stability of electronic nose (eNose)–derived inflammatory phenotypes in patients with severe asthma

• Published in: Journal of allergy and clinical immunology Vol. 143; no. 5; pp. 1811 - 1820.e7
• Main Authors: Brinkman, Paul, Wagener, Ariane H., Hekking, Pieter-Paul, Bansal, Aruna T., Maitland-van der Zee, Anke-Hilse, Wang, Yuanyue, Weda, Hans, Knobel, Hugo H., Vink, Teunis J., Rattray, Nicholas J., D'Amico, Arnaldo, Pennazza, Giorgio, Santonico, Marco, Lefaudeux, Diane, De Meulder, Bertrand, Auffray, Charles, Bakke, Per S., Caruso, Massimo, Chanez, Pascal, Chung, Kian F., Corfield, Julie, Dahlén, Sven-Erik, Djukanovic, Ratko, Geiser, Thomas, Horvath, Ildiko, Krug, Nobert, Musial, Jacek, Sun, Kai, Riley, John H., Shaw, Dominic E., Sandström, Thomas, Sousa, Ana R., Montuschi, Paolo, Fowler, Stephen J., Sterk, Peter J.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.05.2019; Elsevier Limited
• Subjects: Adult; Asthma; Asthma - diagnosis; Biomarkers; Body mass index; Breath Tests; Chronic obstructive pulmonary disease; Cluster Analysis; Cohort Studies; Corticosteroids; Disease Progression; Electronic Nose; Electronic nose technology; Electronic noses; eosinophils; Eosinophils - pathology; Exhalation; exhaled breath; Female; follow-up; Follow-Up Studies; Gene expression; Humans; Independent study; Inflammation; Inflammation - diagnosis; Leukocytes (eosinophilic); Male; Metabolites; Metabolomics; Middle Aged; Neutrophils; Neutrophils - pathology; oral corticosteroids; Patients; Pattern recognition; Phenotype; Phenotypes; severe asthma; Severity of Illness Index; Sputum; unbiased clustering; volatile organic compound; exhaled breath; ERS; eosinophils; IQR; VOC; eNose; Electronic nose technology; oral corticosteroids; GC-MS; TDA; follow-up; TAC; severe asthma; unbiased clustering; volatile organic compound; neutrophils; PAM; OCS

Severe asthma is a heterogeneous condition, as shown by independent cluster analyses based on demographic, clinical, and inflammatory characteristics. A next step is to identify molecularly driven phenotypes using “omics” technologies. Molecular fingerprints of exhaled breath are associated with inf...