Oxygen-independent stabilization of hypoxia inducible factor (HIF)-1 during RSV infection

• Published in: PloS one Vol. 3; no. 10; p. e3352
• Main Authors: Haeberle, Helene A, Dürrstein, Carin, Rosenberger, Peter, Hosakote, Yashoda M, Kuhlicke, Johannes, Kempf, Volkhard A J, Garofalo, Roberto P, Eltzschig, Holger K
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 07.10.2008; Public Library of Science (PLoS)
• Subjects: Anesthesiology; Anesthesiology and Pain Management/Perioperative Critical Care; Animals; Bacterial infections; Biochemistry/Transcription and Translation; Blood Gas Analysis; Blotting, Western; Cancer; CD73 antigen; Cell Biology/Cell Signaling; Cell Line; Critical Care and Emergency Medicine/Pediatric Critical Care; Critical Care and Emergency Medicine/Respiratory Failure; Cyclooxygenase-2; Enzyme-Linked Immunosorbent Assay; Female; Gene expression; Gene Expression Regulation - physiology; Genetics and Genomics/Gene Expression; Hepatitis; Homeostasis; Humans; Hypoxia; Hypoxia-inducible factor 1; Hypoxia-Inducible Factor 1 - metabolism; Hypoxia-Inducible Factor 1 - physiology; Hypoxia-inducible factors; Immunohistochemistry; Immunology/Genetics of the Immune System; Immunology/Immune Response; Immunology/Innate Immunity; In vivo methods and tests; Infections; Infectious Diseases/Respiratory Infections; Infectious Diseases/Viral Infections; Inflammation; Inflammatory bowel disease; Intensive care; Medicine; Metabolism; Mice; Mice, Inbred BALB C; Microbiology/Immunity to Infections; Microbiology/Innate Immunity; Oxygen; Oxygen - blood; Oxygen - metabolism; Oxygen content; Partial pressure; Pediatrics; Physiology; Pneumonitis; Protein folding; Proteins; Respiratory syncytial virus; Respiratory Syncytial Virus Infections - metabolism; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Rodents; siRNA; Studies; Toxoplasma gondii; Transcription factors; Vascular endothelial growth factor; Viral infections; Virology/Animal Models of Infection; Virology/Effects of Virus Infection on Host Gene Expression; Viruses; United States > US; Texas; Germany

Hypoxia-inducible factor 1 (HIF)-1alpha is a transcription factor that functions as master regulator of mammalian oxygen homeostasis. In addition, recent studies identified a role for HIF-1alpha as transcriptional regulator during inflammation or infection. Based on studies showing that respiratory...