The CLK inhibitor SM08502 induces anti-tumor activity and reduces Wnt pathway gene expression in gastrointestinal cancer models - Tam, Betty Y.; Chiu, Kevin; Chung, Heekyung; Bossard, Carine; Nguyen, John Duc; Creger, Emily; Eastman, Brian W.; Mak, Chi Ching; Ibanez, Maureen; Ghias, Abdullah; Cahiwat, Joseph; Do, Long; et al. (Cancer letters, 2020)
Keywords: Alternative splicing; Animal models; Antitumor agents; Arginine; Beta-catenin; Cancer; CDC-Like kinase; Colorectal cancer; Cyclin-dependent kinases; Gastrointestinal cancer; Gene expression; Kinases; Oral administration; Phosphorylation; Proteins; Serine; Signal transduction; Solid tumors; Splicing factors; SRSF; Wnt protein; Xenografts; β-Catenin; United States--US; CDC-Like kinase; Alternative splicing; SRSF; Beta-catenin; Colorectal cancer