DNA methylation regulates phenotype-dependent transcriptional activity in Candida albicans

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 108; no. 29; pp. 11965 - 11970
• Main Authors: Mishra, Prashant K, Baum, Mary, Carbon, John
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 19.07.2011; National Acad Sciences
• Subjects: animal pathogenic fungi; Base Sequence; Biological Sciences; Blotting, Northern; Blotting, Southern; Candida albicans; Candida albicans - genetics; Deoxyribonucleic acid; DNA; DNA methylation; DNA Methylation - genetics; DNA Primers - genetics; Environmental changes; Epigenesis, Genetic - genetics; Epigenetics; eukaryotic cells; Evolution; Gene Expression Regulation, Fungal - genetics; Gene regulation; Genes; Genes, Fungal - genetics; Genetic mutation; Genomes; Genomics; Genotype & phenotype; hyphae; Iron; Iron - metabolism; iron absorption; loci; Metabolism; Methylation; Molecular Sequence Data; multigene family; Mutation; Mutation - genetics; Nematodes; Nutrition; Pathogens; Phenotype; Plasticity; Repeated DNA sequences; Repression; Sequence Analysis, DNA; Sequencing; Species Specificity; structural genes; Transcription; transcription (genetics); Yeasts

DNA methylation is a common epigenetic signaling mechanism associated with silencing of repeated DNA and transcriptional regulation in eukaryotes. Here we report that DNA methylation in the human fungal pathogen Candida albicans is primarily localized within structural genes and modulates transcript...