A Functional Genomic Fingerprint of Chronic Stress in Humans: Blunted Glucocorticoid and Increased NF-κB Signaling

• Published in: Biological psychiatry (1969) Vol. 64; no. 4; pp. 266 - 272
• Main Authors: Miller, Gregory E., Chen, Edith, Sze, Jasmen, Marin, Teresa, Arevalo, Jesusa M.G., Doll, Richard, Ma, Roy, Cole, Steve W.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 2008; Elsevier Science
• Subjects: Biological and medical sciences; Cortisol; genomics; inflammation; Medical sciences; NF-kappa B; Psychiatric/Mental Health; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; stress; stress; genomics; Cortisol; NF-kappa B; inflammation; Human; Corticosteroid; Steroid hormone; Antiinflammatory agent; Inflammation; Hydrocortisone; Glucocorticoid; Stress; Signal transduction; Chronic; Adrenal hormone; Transcription factor NFκB

Chronic stressors are known to increase vulnerability to medical illness, but the mechanisms underlying this phenomenon are poorly understood. To identify transcriptional control pathways that are modified by chronic stress, we conducted genomewide expression microarrays on familial caregivers of br...