Formation mechanism of monodisperse, low molecular weight chitosan nanoparticles by ionic gelation technique

• Published in: Colloids and surfaces, B, Biointerfaces Vol. 90; pp. 21 - 27
• Main Authors: Fan, Wen, Yan, Wei, Xu, Zushun, Ni, Hong
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.02.2012
• Subjects: Acetic acid; Acetic Acid - chemistry; ambient temperature; Biocompatible Materials - chemistry; Chemistry, Pharmaceutical - methods; Chitosan; Chitosan - chemistry; colloids; cross-linking reagents; Cross-Linking Reagents - chemistry; Crosslinking; Drug carrier; Drug Carriers - chemistry; Drug Stability; Drugs; Gelation; Gels - chemistry; gene transfer; hydrodynamics; Ionic cross-linking; Ions; Low molecular weight chitosan; Low molecular weights; Microscopy, Electron, Transmission; Molecular Weight; Monodisperse; Nanoparticles; Nanoparticles - chemistry; Nanoparticles - ultrastructure; Particle Size; particle size distribution; Polyphosphates - chemistry; Sodium; sodium tripolyphosphate; storage quality; Surface Properties; Temperature; zeta potential; Nanoparticles; Drug carrier; Monodisperse; Ionic cross-linking; Low molecular weight chitosan

[Display omitted] ► Monodisperse, low molecular weight chitosan nanoparticles were prepared. ► Various parameters affect the formation of nanoparticles were studied. ► Decreasing acetic acid concentration increases the monodispersity. ► Decreasing ambient temperature during reaction increases the mo...