Reconstruction and analysis of the genome-scale metabolic model of schizochytrium limacinum SR21 for docosahexaenoic acid production

• Published in: BMC genomics Vol. 16; no. 1; p. 799
• Main Authors: Ye, Chao, Qiao, Weihua, Yu, Xiaobin, Ji, Xiaojun, Huang, He, Collier, Jackie L, Liu, Liming
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 16.10.2015; BioMed Central; Springer
• Subjects: BASIC BIOLOGICAL SCIENCES; Bioreactors; Biosynthetic Pathways - genetics; Biotechnology & Applied Microbiology; Docosahexaenoic acid; Docosahexaenoic Acids - biosynthesis; Docosahexaenoic Acids - genetics; Fatty Acids - biosynthesis; Fatty Acids - genetics; Fermentation; Genetics & Heredity; Genome-scale metabolic model; Genomics; Metabolic Engineering; Minimization of metabolic adjustment algorithm; Polyketide synthase system; Polyketide Synthases - genetics; Polyketide Synthases - metabolism; Schizochytrium limacinum SR21; Stramenopiles - genetics; Stramenopiles - metabolism

Schizochytrium limacinum SR21 is a potential industrial strain for docosahexaenoic acid (DHA) production that contains more than 30-40 % DHA among its total fatty acids. To resolve the DHA biosynthesis mechanism and improve DHA production at a systematic level, a genomescale metabolic model (GSMM),...