Mild cognitive impairment associates with concurrent decreases in serum cholesterol and cholesterol-related lipoprotein subclasses

• Published in: The Journal of nutrition, health & aging Vol. 16; no. 7; pp. 631 - 635
• Main Authors: Tukiainen, T, Jylänki, P, Mäkinen, V. -P, Gröhn, O, Hallikainen, M, Soininen, H, Kivipelto, M, Kaski, K, Groop, P. -H, Savolainen, M. J, Pirttilä, T, Soininen, P, Ala-Korpela, Mika
• Format: Journal Article
• Language: English
• Published: Paris Springer-Verlag 2012; Springer; Springer Nature B.V
• Subjects: Aged; Aged, 80 and over; Aging; Alzheimer's disease; Biological and medical sciences; blood lipids; blood serum; central nervous system diseases; Cholesterol; Cholesterol - blood; Clinical medicine; cognition; Cognitive ability; Cognitive Dysfunction - blood; Cognitive Dysfunction - diagnosis; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Dementia; Dementia - blood; Dementia - diagnosis; elderly; Feeding. Feeding behavior; Female; Finland; Follow-Up Studies; Fundamental and applied biological sciences. Psychology; Geriatrics; Geriatrics/Gerontology; High density lipoprotein; Humans; Lipids; lipoprotein; Lipoproteins; Longitudinal Studies; Male; Medical sciences; Medicin och hälsovetenskap; Medicine; Medicine & Public Health; Mild cognitive impairment; Neurology; Neuropsychology; Neurosciences; NMR; Nuclear magnetic resonance; nuclear magnetic resonance spectroscopy; Nutrition; Older people; people; Primary Care Medicine; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Quality of Life Research; Research centers; Statistics, Nonparametric; Trends; triacylglycerols; triglyceride; Triglycerides - blood; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Finland; triglyceride; cholesterol; Alzheimer’s disease; Mild cognitive impairment; lipoprotein; Nervous system diseases; Cognitive disorder; Alzheimer disease; Lipids; Metabolic diseases; Lipoprotein; Triglyceride; Cholesterol; Cerebral disorder; Central nervous system disease; Serum; Degenerative disease; mild cognitive impairment; Alzheimer's disease
• ISSN: 1279-7707; 1760-4788; 1760-4788
• DOI: 10.1007/s12603-011-0341-9

BACKGROUND AND OBJECTIVE: Accumulating evidence suggests that serum lipids are associated with cognitive decline and dementias. However, majority of the existing information concerns only serum total cholesterol (TC) and data at the level of lipoprotein fractions and subclasses is limited. The aim of this study was to explore the levels and trends of main cholesterol and triglyceride measures and eight lipoprotein subclasses during normal aging and the development of mild cognitive impairment by following a group of elderly for six years. DESIGN: Longitudinal. SETTING: City of Kuopio, Finland. PARTICIPANTS: 45 elderly individuals of which 20 developed mild cognitive impairment (MCI) during the follow-up. MEASUREMENTS: On each visit participants underwent an extensive neuropsychological and clinical assessment. Lipoprotein levels were measured via ¹H NMR from native serum samples. RESULTS: Serum cholesterol and many primarily cholesterol-associated lipoprotein measures clearly decreased in MCI while the trends were increasing for those elderly people who maintained normal cognition. CONCLUSION: These findings suggest that a decreasing trend in serum cholesterol measures in elderly individuals may suffice as an indication for more detailed inspection for potential signs of cognitive decline.