Rational Design of Envelope Identifies Broadly Neutralizing Human Monoclonal Antibodies to HIV-1 - Wu, Xueling; Yang, Zhi-Yong; Li, Yuxing; Hogerkorp, Carl-Magnus; Schief, William R; Seaman, Michael S; Zhou, Tongqing; Schmidt, Stephen D; Wu, Lan; Xu, Ling; Longo, Nancy S; McKee, Krisha; et al. (Science (American Association for the Advancement of Science), 2010)
Keywords: AIDS Vaccines; Amino acids; Antibodies; Antibodies, Monoclonal - immunology; Antibodies, Monoclonal - isolation & purification; Antibodies, Neutralizing - immunology; Antibodies, Neutralizing - isolation & purification; Antibody Specificity; B lymphocytes; B-Lymphocytes - immunology; Binding; Binding Sites, Antibody; CD4 Antigens - immunology; CD4 Antigens - metabolism; Circulating; Cross Reactions; Drug Design; Envelopes; Enzyme linked immunosorbent assay; Epitopes - immunology; Genes; Genes, Immunoglobulin Heavy Chain; Genes, Immunoglobulin Light Chain; Glycoprotein; Glycoproteins; HIV; HIV 1; HIV Antibodies - immunology; HIV Antibodies - isolation & purification; HIV Envelope Protein gp120 - chemistry; HIV Envelope Protein gp120 - immunology; HIV Envelope Protein gp120 - metabolism; HIV infections; HIV Infections - immunology; HIV Infections - virology; HIV-1 - genetics; HIV-1 - immunology; Human immunodeficiency virus; Human immunodeficiency virus 1; Humans; immunoglobulin genes; Immunoglobulins; Immunology; Infectious diseases; Molecular Sequence Data; Monoclonal antibodies; Neutralization; Neutralization Tests; Neutralizing; neutralizing antibodies; Protein Engineering; Proteins; Reactivity; Recombinant Proteins - chemistry; Recombinant Proteins - immunology; Recombinant Proteins - metabolism; Research facilities; Vaccines; Viruses