Fish-oil supplementation induces antiinflammatory gene expression profiles in human blood mononuclear cells

• Published in: The American journal of clinical nutrition Vol. 90; no. 2; pp. 415 - 424
• Main Authors: Bouwens, Mark, van de Rest, Ondine, Dellschaft, Neele, Bromhaar, Mechteld Grootte, de Groot, Lisette CPGM, Geleijnse, Johanna M, Müller, Michael, Afman, Lydia A
• Format: Journal Article
• Language: English
• Published: Bethesda, MD American Society for Clinical Nutrition 01.08.2009; American Society for Nutrition; American Society for Clinical Nutrition, Inc
• Subjects: activated receptor-alpha; administration & dosage; Aged; Aged, 80 and over; analysis; anti-inflammatory agents; antiatherogenic status; Biological and medical sciences; Blood; blood cells; Cells; controlled-trial; cytokine production; Dietary Supplements; disease prevention; DNA, Complementary; DNA, Complementary - analysis; docosahexaenoic acid; Docosahexaenoic Acids; Docosahexaenoic Acids - administration & dosage; dose response; Dose-Response Relationship, Drug; Double-Blind Method; drug effects; eicosapentaenoic acid; Eicosapentaenoic Acid - administration & dosage; elderly; Fatty acids; Fatty Acids, Omega-3; Fatty Acids, Omega-3 - administration & dosage; Fatty Acids, Unsaturated; Fatty Acids, Unsaturated - administration & dosage; Feeding. Feeding behavior; Female; Fish oils; Fish Oils - administration & dosage; Fish Oils - pharmacology; Fundamental and applied biological sciences. Psychology; Gene expression; Gene Expression Profiling; gene expression regulation; Genes; Helianthus; human diseases; Humans; Immune system; inflammation; Inflammation - prevention & control; Leukocytes, Mononuclear; Leukocytes, Mononuclear - drug effects; Leukocytes, Mononuclear - metabolism; Male; men; metabolism; Microarray Analysis; murine macrophages; n-3; Netherlands; nitric-oxide; nutrigenomics; Nutrition; oxidative stress; peripheral blook mononuclear cells; pharmacology; Polymerase Chain Reaction; polyunsaturated fatty acids; prevention & control; RNA; RNA - analysis; transcriptional activation; Vertebrates: anatomy and physiology, studies on body, several organs or systems; women; Netherlands; Human; Blood cell; Mononuclear cell; Antiinflammatory agent; Supplementation; Gene expression; Fish oil

BACKGROUND: Polyunsaturated fatty acids can have beneficial effects on human immune cells, such as peripheral blood mononuclear cells (PBMCs). However, the mechanisms of action of polyunsaturated fatty acids on immune cells are still largely unknown. OBJECTIVE: The objective was to examine the effec...