Normal human gingival fibroblasts undergo cytostasis and apoptosis after long-term exposure to butyric acid

• Published in: Biochemical and biophysical research communications Vol. 482; no. 4; pp. 1122 - 1128
• Main Authors: Shirasugi, Michihiro, Nishioka, Keisuke, Yamamoto, Toshiro, Nakaya, Takaaki, Kanamura, Narisato
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 22.01.2017
• Subjects: Animals; Apoptosis; Butyric acid; Butyric Acid - chemistry; Caspase 8 - metabolism; Cell Division; Cell Survival; Cytokines - metabolism; DNA Damage; Fibroblasts - drug effects; Fibroblasts - metabolism; Gingiva - drug effects; Gingiva - metabolism; Human gingival fibroblast; Humans; Inflammation; Mice; Periodontal disease; RAW 264.7 Cells; TNF-alpha; Tumor Necrosis Factor-alpha - metabolism; Tumor Suppressor Protein p53 - metabolism; Periodontal disease; TNF-alpha; Human gingival fibroblast; Butyric acid; Apoptosis

The causes of periodontal disease are complex. Butyric acid, a metabolite of periodontopathic bacteria such as Porphyromonas gingivalis, acts as a histone deacetylase inhibitor that has a direct effect on mRNA expression. Butyric acid produced by Clostridium butyricum in the intestinal tract induces...