Stromal fibroblasts shape the myeloid phenotype in normal colon and colorectal cancer and induce CD163 and CCL2 expression in macrophages - Stadler, Mira; Pudelko, Karoline; Biermeier, Alexander; Walterskirchen, Natalie; Gaigneaux, Anthoula; Weindorfer, Claudia; Harrer, Nathalie; Klett, Hagen; Hengstschläger, Markus; Schüler, Julia; Sommergruber, Wolfgang; Oehler, Rudolf; et al. (Cancer letters, 2021)
Keywords: Angiogenesis; Antigens; Antigens, CD - genetics; Antigens, Differentiation, Myelomonocytic - genetics; Cancer associated fibroblasts; Cancer-Associated Fibroblasts - metabolism; Cancer-Associated Fibroblasts - pathology; Carcinogenesis; CCL2; CCR2 protein; CD163 antigen; Cell adhesion & migration; Cell culture; Cell Differentiation - genetics; Cell Movement - genetics; Cell Proliferation - genetics; Chemokine CCL2 - genetics; Collagen; Colon - metabolism; Colon - pathology; Colon cancer; Colorectal cancer; Colorectal carcinoma; Colorectal Neoplasms - blood; Colorectal Neoplasms - genetics; Colorectal Neoplasms - metabolism; Colorectal Neoplasms - pathology; Female; Fibroblasts; Flow cytometry; Gene Expression Regulation, Neoplastic - genetics; HCT116 Cells; Homeostasis; Humans; Immune cell recruitment and polarization; Interleukin 6; Interleukin 8; Macrophage colony-stimulating factor; Macrophage Colony-Stimulating Factor - genetics; Macrophages; Male; Medical prognosis; Monocyte chemoattractant protein 1; Monocytes; Myeloid Cells - metabolism; Myeloid Cells - pathology; Phenotypes; Pore size; Receptors, Cell Surface - genetics; Signal Transduction - genetics; Spheroids; Tumor cells; Tumor microenvironment; Tumor Microenvironment - genetics; United States--US; Germany; CCL2; Colon cancer; Cancer associated fibroblasts; Tumor microenvironment; Immune cell recruitment and polarization