Insulin-related traits and prostate cancer: A Mendelian randomization study

• Published in: Computational and structural biotechnology journal Vol. 23; pp. 2337 - 2344
• Main Authors: Chen, Guihua, Wang, Yi, Wang, Xiang
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.12.2024; Research Network of Computational and Structural Biotechnology; Elsevier
• Subjects: biotechnology; body fat; carcinogenesis; diabetes; Insulin; insulin resistance; insulin secretion; insulin-like growth factor I; Insulin-like growth factor-1; Mendelian randomization; obesity; Proinsulin; Prostate cancer; prostatic neoplasms; Proinsulin; FI; GWAS; MR; IVs; Insulin-like growth factor-1; STROBE; IGF-1; IVW; Mendelian randomization; Insulin; PCa; HOMA-IR; nonDM; SNP; MAGIC; LD; PRACTICAL; Prostate cancer; ISI; BMI

Investigating the causal relationship between insulin secretion and prostate cancer (PCa) development is challenging due to the multifactorial nature of PCa, which complicates the isolation of the specific impact of insulin-related factors. We conducted a Mendelian randomization (MR) study to invest...