A Novel Preclinical Murine Model to Monitor Inflammatory Breast Cancer Tumor Growth and Lymphovascular Invasion

• Published in: Cancers Vol. 15; no. 8; p. 2261
• Main Authors: Rickard, Ashlyn G, Sannareddy, Dorababu S, Bennion, Alexandra, Patel, Pranalee, Sauer, Scott J, Rouse, Douglas C, Bouchal, Samantha, Liu, Harrison, Dewhirst, Mark W, Palmer, Gregory M, Devi, Gayathri R
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.04.2023; MDPI
• Subjects: Animal models; Blood vessels; Breast cancer; Cancer therapies; Development and progression; Edema; Erythema; Fluorescence microscopy; Inflammation; inflammatory breast cancer (IBC); Laboratory animals; lymphatic vessels; Metastases; Metastasis; Microscopy; migration; Skin window; SUM149; Surgery; Surgical outcomes; Transgenic animals; Transgenic mice; Tumor cells; Tumor microenvironment; Tumors; window chamber; United States; United States > US; SUM149; lymphatic vessels; migration; tumor microenvironment; inflammatory breast cancer (IBC); window chamber

Inflammatory breast cancer (IBC), an understudied and lethal breast cancer, is often misdiagnosed due to its unique presentation of diffuse tumor cell clusters in the skin and dermal lymphatics. Here, we describe a window chamber technique in combination with a novel transgenic mouse model that has...