The Ebola Virus Matrix Protein VP40 Selectively Induces Vesiculation from Phosphatidylserine-enriched Membranes

• Published in: The Journal of biological chemistry Vol. 289; no. 48; pp. 33590 - 33597
• Main Authors: Soni, Smita P., Stahelin, Robert V.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 28.11.2014; American Society for Biochemistry and Molecular Biology
• Subjects: Ebola Virus; Ebolavirus - chemistry; Ebolavirus - metabolism; Giant Unilammelar Vesicles; Lipid Binding Protein; Lipids; Matrix Protein; Membrane Budding; Membranes, Artificial; Models, Biological; Phosphatidylserine; Phosphatidylserines - chemistry; Phosphatidylserines - metabolism; Viral Budding; Viral Matrix Proteins - chemistry; Viral Matrix Proteins - metabolism; Viral Protein; Virus Assembly; Virus Release - physiology; VP40; Viral Protein; Membrane Budding; Lipid Binding Protein; Ebola Virus; Giant Unilammelar Vesicles; Viral Budding; Virus Assembly; Matrix Protein; Phosphatidylserine; VP40

Ebola virus is from the Filoviridae family of viruses and is one of the most virulent pathogens known with ∼60% clinical fatality. The Ebola virus negative sense RNA genome encodes seven proteins including viral matrix protein 40 (VP40), which is the most abundant protein found in the virions. Withi...