Evaluation of Vitamin B12, Folate and Ferritin Serum Levels in Jordanian Population

Vitamin B12, folate, and ferritin are vital for the development of the nervous system, blood formation, and diverse metabolic functions. The aim of the current study is to evaluate the status of vitamin B12, folate and ferritin in the Jordanian population across distinct geographical locations. In t...

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Published inJournal of Nutritional Science and Vitaminology Vol. 65; no. 4; pp. 309 - 317
Main Authors ZOUBI, Mazhar Salim AL, AL-BATAYNEH, Khalid M., AL-TRAD, Bahaa, HADDAD, Yazan, HUSSEIN, Emad, KHATEEB, Wesam AL, ALJABALI, Alaa A. A., BODOOR, Khaldon, SHEHAB, Murad, HAMAD, Mohammad AL, MUHAIDAT, Riyadh
Format Journal Article
LanguageEnglish
Published Japan Center for Academic Publications Japan 31.08.2019
Subjects
Adolescent
Adult
Aged
Aged, 80 and over
Child
Child, Preschool
cobalamin
Female
Ferritins - blood
Ferritins - deficiency
folic acid
Folic Acid - blood
geographical location
Humans
iron deficiency
Jordan - epidemiology
Male
micronutrients
Middle Aged
Retrospective Studies
Sex Factors
Vitamin B 12 - blood
Vitamin B 12 Deficiency - epidemiology
Young Adult
Jordan
geographical location
micronutrients
cobalamin
iron deficiency
folic acid
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Abstract Vitamin B12, folate, and ferritin are vital for the development of the nervous system, blood formation, and diverse metabolic functions. The aim of the current study is to evaluate the status of vitamin B12, folate and ferritin in the Jordanian population across distinct geographical locations. In this retrospective study, the cohort population included 2,880 Jordanian individuals with an average age of 47 y for males and 34 y for females (January 2014-December 2016). Vitamin B12, folate, and ferritin were measured in the blood samples by immunoassay on an automated instrument. Prevalence of low levels of vitamin B12 among males and females was similar across the four regions (24%). Equivalently high levels of folate were reported in males (24.4%) and females (23.4%). Additionally, 37.4% of males and 20.4% of females showed low levels of ferritin. Pearson’s correlations did not show any association between age, vitamin B12, folate, and ferritin levels in both sexes. Univariate odd ratio (OR) and age-adjusted OR in males showed a significant decrease in low vitamin B12 risk in the region of Tafela when compared to Irbid. In conclusion, our results showed a significant difference in vitamin B12 levels between populations according to their geographical locations. Ferritin levels were low in almost a quarter of the Jordanian population with a high prevalence in males and females in Irbid and Maan, respectively. These differences might be associated with the genetic, dietary and lifestyle situation which requires further studies to elucidate the risk factors for vitamin B12 and ferritin deficiency.
AbstractList Vitamin B12, folate, and ferritin are vital for the development of the nervous system, blood formation, and diverse metabolic functions. The aim of the current study is to evaluate the status of vitamin B12, folate and ferritin in the Jordanian population across distinct geographical locations. In this retrospective study, the cohort population included 2,880 Jordanian individuals with an average age of 47 y for males and 34 y for females (January 2014-December 2016). Vitamin B12, folate, and ferritin were measured in the blood samples by immunoassay on an automated instrument. Prevalence of low levels of vitamin B12 among males and females was similar across the four regions (24%). Equivalently high levels of folate were reported in males (24.4%) and females (23.4%). Additionally, 37.4% of males and 20.4% of females showed low levels of ferritin. Pearson’s correlations did not show any association between age, vitamin B12, folate, and ferritin levels in both sexes. Univariate odd ratio (OR) and age-adjusted OR in males showed a significant decrease in low vitamin B12 risk in the region of Tafela when compared to Irbid. In conclusion, our results showed a significant difference in vitamin B12 levels between populations according to their geographical locations. Ferritin levels were low in almost a quarter of the Jordanian population with a high prevalence in males and females in Irbid and Maan, respectively. These differences might be associated with the genetic, dietary and lifestyle situation which requires further studies to elucidate the risk factors for vitamin B12 and ferritin deficiency.
Author ZOUBI, Mazhar Salim AL
AL-BATAYNEH, Khalid M.
BODOOR, Khaldon
HADDAD, Yazan
ALJABALI, Alaa A. A.
AL-TRAD, Bahaa
SHEHAB, Murad
HAMAD, Mohammad AL
HUSSEIN, Emad
KHATEEB, Wesam AL
MUHAIDAT, Riyadh
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  fullname: ZOUBI, Mazhar Salim AL
  organization: Department of Basic Medical Sciences, Faculty of Medicine, Yarmouk University
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  fullname: MUHAIDAT, Riyadh
  organization: Department of Biological Sciences, Faculty of Science, Yarmouk University
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Cites_doi 10.1016/j.jcma.2016.07.005
10.1016/j.thromres.2006.05.009
10.1017/S0007114509992947
10.4103/1319-2442.135178
10.1016/j.nutres.2015.10.003
10.1016/j.nut.2015.08.019
10.26719/2009.15.4.853
10.1038/ejcn.2014.142
10.1016/j.biochi.2012.11.017
10.1056/NEJMcp1113996
10.1542/peds.2008-1173
10.1038/ejcn.2014.100
10.26719/2014.20.1.51
10.1002/bdra.23418
10.1016/j.mcna.2016.09.013
10.1016/j.jphotobiol.2014.07.001
10.1159/000355440
10.1111/j.1365-2141.2010.08198.x
10.3945/an.115.008201
10.1309/LMG2E7PEDHET5QVI
10.1515/jomb-2017-0051
10.3181/0703-MR-67
10.1146/annurev.nutr.24.012003.132440
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References 6) Belghith A, Mahjoub S, Ben Romdhane N. 2015. Causes of vitamin B12 deficiency. Tunis Med 93(11): 678-682.
9) Nasri K, Ben Fradj MK, Touati A, Aloui M, Ben Jemaa N, Masmoudi A, Elmay MV, Omar S, Feki M, Kaabechi N, Marrakchi R, Gaigi SS. 2015. Association of maternal homocysteine and vitamins status with the risk of neural tube defects in Tunisia: A case-control study. Birth Defects Res A Clin Mol Teratol 103(12): 1011-1020.
3) Koury MJ, Ponka P. 2004. New insights into erythropoiesis: the roles of folate, vitamin B12, and iron. Annu Rev Nutr 24: 105-131.
8) Finkelstein JL, Layden AJ, Stover PJ. 2015. Vitamin B-12 and perinatal health. Adv Nutr 6(5): 552-563.
24) Fischbach FT, Dunning MB. 2009. A Manual of Laboratory and Diagnostic Tests. Lippincott Williams & Wilkins, Philadelphia.
27) Kumar N. 2017. Nutrients and neurology. Continuum (Minneap Minn) 23(3, Neurology of Systemic Disease): 822-861.
4) Watanabe F. 2007. Vitamin B12 sources and bioavailability. Exp Biol Med (Maywood) 232(10): 1266-1274.
26) WHO. 2015. Serum and red blood cell folate concentrations for assessing folate status in populations.
12) Molloy AM, Kirke PN, Troendle JF, Burke H, Sutton M, Brody LC, Scott JM, Mills JL. 2009. Maternal vitamin B12 status and risk of neural tube defects in a population with high neural tube defect prevalence and no folic acid fortification. Pediatrics 123(3): 917-923.
11) Spence JD. 2016. Metabolic vitamin B12 deficiency: a missed opportunity to prevent dementia and stroke. Nutr Res 36(2): 109-116.
13) Farahid OH, Khawaja N, Shennak MM, Batieha A, El-Khateeb M, Ajlouni K. 2014. Prevalence of coeliac disease among adult patients with autoimmune hypothyroidism in Jordan. East Mediterr Health J 20(1): 51-55.
7) Thuesen BH, Husemoen LL, Ovesen L, Jørgensen T, Fenger M, Linneberg A. 2010. Lifestyle and genetic determinants of folate and vitamin B12 levels in a general adult population. Br J Nutr 103(8): 1195-1204.
14) Hazza IA, Ghandour MS, Almardini RI, Haddad RE, Salaita GM. 2014. Hypercalcemia, hypercalciuria and nephrocalcinosis in a breast-fed term newborn: a rare presentation. Saudi J Kidney Dis Transpl 25(4): 849-853.
5) Stabler SP, Allen RH. 2004. Vitamin B12 deficiency as a worldwide problem. Annu Rev Nutr 24: 299-326.
17) Alazzam SI, Alzoubi KH, Al-Hambouth LT, Almahasneh F, Aburuz SM. 2011. No correlation exists between vitamin B12 and quality of life in healthy young adult population. Eur Rev Med Pharmacol Sci 15(10): 1176-1181.
22) Overgaard UM, Tanner SM, Birgens HS. 2010. Vitamin B12 deficiency in a 15-year old boy due to mutations in the intrinsic factor gene, GIF. Br J Haematol 150(3): 369-371.
18) Ramirez-Velez R, Correa-Bautista JE, Martínez-Torres J, Meneses-Echávez JF, Lobelo F. 2016. Vitamin B12 concentration and its association with sociodemographic factors in Colombian children: Findings from the 2010 National Nutrition Survey. Nutrition 32(2): 255-259.
21) Alessio AC, Höehr NF, Siqueira LH, Bydlowski SP, Annichino-Bizzacchi JM. 2007. Polymorphism C776G in the transcobalamin II gene and homocysteine, folate and vitamin B12 concentrations. Association with MTHFR C677T and A1298C and MTRR A66G polymorphisms in healthy children. Thromb Res 119(5): 571-577.
1) Toohey JI. 2006. Vitamin B12 and methionine synthesis: a critical review. Is nature’s most beautiful cofactor misunderstood? Biofactors 26(1): 45-57.
25) Stabler SP. 2013. Vitamin B12 deficiency. New Engl J Med 368(2): 149-160.
31) Fora MA, Mohammad MA. 2005. High frequency of suboptimal serum vitamin B12 level in adults in Jordan. Saudi Med J 26(10): 1591-1595.
10) McCaddon A. 2013. Vitamin B12 in neurology and ageing; clinical and genetic aspects. Biochimie 95(5): 1066-1076.
15) Nichols EK, Khatib IM, Aburto NJ, Serdula MK, Scanlon KS, Wirth JP, Sullivan KM. 2015. Vitamin D status and associated factors of deficiency among Jordanian children of preschool age. Eur J Clin Nutr 69(1): 90-95.
16) Serdula MK, Nichols EK, Aburto NJ, Masa’d H, Obaid B, Wirth J, Tarawneh M, Barham R, Hijawi B, Sullivan KM. 2014. Micronutrient status in Jordan: 2002 and 2010. Eur J Clin Nutr 68(10): 1124-1128.
20) Ni J, Zhang L, Zhou T, Xu WJ, Xue JL, Cao N, Wang X. 2017. Association between the MTHFR C677T polymorphism, blood folate and vitamin B12 deficiency, and elevated serum total homocysteine in healthy individuals in Yunnan Province, China. J Chin Med Assoc 80(3): 147-153.
30) Barghouti FF, Younes NA, Halaseh LJ, Said TT, Ghraiz SM. 2009. High frequency of low serum levels of vitamin B12 among patients attending Jordan University Hospital. East Mediterr Health J 15(4): 853-860.
29) El-Qudah JM, Dababneh BF, Al-Qudah MM, Haddad M. 2013. Serum vitamin B12 levels related to weight status among healthy Jordanian students. Laboratory Medicine 44(1): 34-39.
32) El-Khateeb, M, Khader Y, Batieha A, Jaddou H, Hyassat D, Belbisi A, Ajlouni K. 2014. Vitamin B12 deficiency in Jordan: a population-based study. Ann Nutr Metab 64(2): 101-105.
23) Al-Batayneh KM, Zoubi MSA, Shehab M, Al-Trad B, Bodoor K, Khateeb WA, Aljabali AAA, Hamad MA, Eaton G. 2018. Association between MTHFR 677C>T polymorphism and vitamin B12 deficiency: A case-control study. J Med Biochem 37(2): 141-147.
2) Miller A, Korem M, Almog R, Galboiz Y. 2005. Vitamin B12, demyelination, remyelination and repair in multiple sclerosis. J Neurol Sci 233(1-2): 93-97.
19) Cabrera S, Benavente D, Alvo M, de Pablo P, Ferro CJ. 2014. Vitamin B12 deficiency is associated with geographical latitude and solar radiation in the older population. J Photochem Photobiol B 140: 8-13.
28) Green R, Datta Mitra A. 2017. Megaloblastic anemias: Nutritional and other causes. Med Clin North Am 101(2): 297-317.
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13
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  doi: 10.1016/j.jcma.2016.07.005
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  doi: 10.1056/NEJMcp1113996
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  doi: 10.1542/peds.2008-1173
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  doi: 10.1038/ejcn.2014.100
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  doi: 10.26719/2014.20.1.51
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  doi: 10.1002/bdra.23418
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  doi: 10.1159/000355440
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  doi: 10.1111/j.1365-2141.2010.08198.x
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  doi: 10.3945/an.115.008201
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  doi: 10.1309/LMG2E7PEDHET5QVI
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  doi: 10.1515/jomb-2017-0051
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  doi: 10.3181/0703-MR-67
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SubjectTerms Adolescent
Adult
Aged
Aged, 80 and over
Child
Child, Preschool
cobalamin
Female
Ferritins - blood
Ferritins - deficiency
folic acid
Folic Acid - blood
geographical location
Humans
iron deficiency
Jordan - epidemiology
Male
micronutrients
Middle Aged
Retrospective Studies
Sex Factors
Vitamin B 12 - blood
Vitamin B 12 Deficiency - epidemiology
Young Adult
Title Evaluation of Vitamin B12, Folate and Ferritin Serum Levels in Jordanian Population
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