Loss of phosphatase and tensin homolog (PTEN) increases Lysyl oxidase-like 2 (LOXL2) expression enhancing the growth of fallopian tube epithelial cells as three-dimensional spheroids

• Published in: Cancer pathogenesis and therapy Vol. 3; no. 1; pp. 68 - 75
• Main Authors: Russo, Angela, Moy, Junlone, Khin, Manead, Dorsey, Timothy R., Lopez Carrero, Alfredo, Burdette, Joanna E.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.01.2025; Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois, Chicago, IL 60607, USA%College of Pharmacy, University of Illinois, Chicago, IL 60612, USA; Elsevier
• Subjects: Fallopian tube; LOXL2; Ovarian cancer; PAX2; PTEN; PTEN; Fallopian tube; PAX2; LOXL2; Ovarian cancer

High-grade serous ovarian cancer (HGSOC) accounts for 70–80% of all ovarian cancer-related deaths. Multiple studies have suggested that the fallopian tube epithelium (FTE) serves as the cell of origin of HGSOC. Phosphatase and tensin homolog (PTEN) is a tumor suppressor and its loss is sufficient to...