Peri-tumor associated fibroblasts promote intrahepatic metastasis of hepatocellular carcinoma by recruiting cancer stem cells

• Published in: Cancer letters Vol. 404; pp. 19 - 28
• Main Authors: Jiang, Jinghua, Ye, Fei, Yang, Xue, Zong, Chen, Gao, Lu, Yang, Yang, Zhao, Qiudong, Han, Zhipeng, Wei, Lixin
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 28.09.2017; Elsevier Limited
• Subjects: Animals; Biomarkers, Tumor - metabolism; Cancer stem cells; Cancer therapies; Cancer-Associated Fibroblasts - metabolism; Cancer-Associated Fibroblasts - pathology; Carcinoma, Hepatocellular - metabolism; Carcinoma, Hepatocellular - pathology; Carcinoma, Hepatocellular - secondary; CCL2; CCR2 protein; Cell culture; Cell cycle; CXCL8; Cytokines; Cytokines - metabolism; Disease Models, Animal; Fibroblasts; Flow cytometry; Growth factors; Hepatocellular carcinoma; Humans; IL-6; Immunohistochemistry; Interleukin 6; Intrahepatic metastasis; Liver cancer; Liver Neoplasms - metabolism; Liver Neoplasms - pathology; Liver Neoplasms - secondary; Male; Medical prognosis; Metastases; Metastasis; Mice; Mice, Inbred BALB C; Monocyte chemoattractant protein 1; Neoplasm Metastasis - pathology; Neoplastic Stem Cells - metabolism; Rodents; Stem cells; Surgery; Tumor Cells, Cultured; Tumorigenesis; Tumors; Vascular endothelial growth factor; Wound healing; Fibroblasts; CCL2; CXCL8; Cancer stem cells; Intrahepatic metastasis; IL-6

Fibroblasts have been reported to play an important role in hepatocellular carcinoma (HCC). However, the role of fibroblasts have not been fully understood. Conditioned medium collected from human peri-tumor tissue-derived fibroblasts (CM-pTAFs) showed high metastasis ability than human HCC tissues-...