Role of p53 codon 72 polymorphism in chromosomal aberrations and mitotic index in patients with chronic hepatitis B

• Published in: Brazilian journal of medical and biological research Vol. 45; no. 11; pp. 1011 - 1016
• Main Authors: Akbaş, H., Yalcin, K., Isi, H., Tekes, S., Atay, A.E., Akkus, Z., Budak, T.
• Format: Journal Article
• Language: English
• Published: Brazil Sociedade Brasileira de Medicina Tropical 01.11.2012; Associação Brasileira de Divulgação Científica
• Subjects: Adult; Arginine - genetics; BIOLOGY; Case-Control Studies; Chromosomal aberrations; Chromosome Aberrations; Codon - genetics; Female; Genetic Predisposition to Disease; Genotype; Hepatitis B; Hepatitis B virus; Hepatitis B, Chronic - genetics; Humans; Male; MEDICINE, RESEARCH & EXPERIMENTAL; Mitotic Index; p53 gene codon 72 polymorphism; Polymorphism, Genetic - genetics; Proline - genetics; Short Communication; Tumor Suppressor Protein p53 - genetics; Mitotic index; Chromosomal aberrations; p53 gene codon 72 polymorphism; Hepatitis B

Polymorphisms of the p53 gene, which participates in DNA repair, can affect the functioning of the p53 protein. The Arg and Pro variants in p53 codon 72 were shown to have different regulation properties of p53-dependent DNA repair target genes that can affect various levels of cytogenetic aberratio...