VAV2 signaling promotes regenerative proliferation in both cutaneous and head and neck squamous cell carcinoma

• Published in: Nature communications Vol. 11; no. 1; p. 4788
• Main Authors: Lorenzo-Martín, L. Francisco, Fernández-Parejo, Natalia, Menacho-Márquez, Mauricio, Rodríguez-Fdez, Sonia, Robles-Valero, Javier, Zumalave, Sonia, Fabbiano, Salvatore, Pascual, Gloria, García-Pedrero, Juana M., Abad, Antonio, García-Macías, María C., González, Nazareno, Lorenzano-Menna, Pablo, Pavón, Miguel A., González-Sarmiento, Rogelio, Segrelles, Carmen, Paramio, Jesús M., Tubío, José M. C., Rodrigo, Juan P., Benitah, Salvador A., Cuadrado, Myriam, Bustelo, Xosé R.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 22.09.2020; Nature Portfolio
• Subjects: 13/1; 13/105; 13/106; 13/109; 13/44; 13/51; 13/95; 14/19; 38/23; 38/39; 38/61; 38/77; 38/90; 42/41; 45/29; 631/67/70; 631/80/86/2341; 64/110; 64/60; Humanities and Social Sciences; multidisciplinary; Science; Science (multidisciplinary)

Regenerative proliferation capacity and poor differentiation are histological features usually linked to poor prognosis in head and neck squamous cell carcinoma (hnSCC). However, the pathways that regulate them remain ill-characterized. Here, we show that those traits can be triggered by the RHO GTP...