Possibility of Diarrheal Effect by Eicosapentaenoic Acid (EPA) and Autoxidized EPA

• Published in: Eisei Kagaku Vol. 39; no. 2; pp. 100 - 105
• Main Authors: SAJIKI, JUNKO, YAMANAKA, TAKAYA, TAKAHASHI, HARUO, TSURUOKA, YOSHIHISA, MORI, KEIJI, TAKAHASHI, KATSUHIRO, HAYASHI, AKIFUMI
• Format: Journal Article Conference Proceeding
• Language: English; Japanese
• Published: Tokyo The Pharmaceutical Society of Japan 1993; Nippon Yakugakkai
• Subjects: autoxidized EPA; Biological and medical sciences; diarrheal activity; eicosapentaenoic acid (EPA); Food toxicology; Medical sciences; mouse peritoneal injection test; rabbit intestinal loop test; suckling mouse diarrheal test; Toxicology; Edible mollusc; Metabolite; Toxicity; Rodentia; Diarrhea; Rabbit; Toxicity test; Lagomorpha; Contamination; Autoxidation; Vertebrata; Mammalia; Mouse; Animal; Quality control; Digestive diseases; Eicosapentaenoic acid; Food

A study on the possibility of diarrhea induced by EPA and autoxidized EPA (EPA-Ox ; 61.6% decomposition) was conducted using several assays on rabbits and suckling mice. The result of loop test of both EPA and EPA-Ox in rabbit intestine showed positive diarrheal effect at the dose of more than 12.5...