Possibility of Diarrheal Effect by Eicosapentaenoic Acid (EPA) and Autoxidized EPA
A study on the possibility of diarrhea induced by EPA and autoxidized EPA (EPA-Ox ; 61.6% decomposition) was conducted using several assays on rabbits and suckling mice. The result of loop test of both EPA and EPA-Ox in rabbit intestine showed positive diarrheal effect at the dose of more than 12.5...
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Published in | Eisei Kagaku Vol. 39; no. 2; pp. 100 - 105 |
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Main Authors | , , , , , , |
Format | Journal Article Conference Proceeding |
Language | English Japanese |
Published |
Tokyo
The Pharmaceutical Society of Japan
1993
Nippon Yakugakkai |
Subjects | |
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Abstract | A study on the possibility of diarrhea induced by EPA and autoxidized EPA (EPA-Ox ; 61.6% decomposition) was conducted using several assays on rabbits and suckling mice. The result of loop test of both EPA and EPA-Ox in rabbit intestine showed positive diarrheal effect at the dose of more than 12.5 mg per loop though the degree of effect depended on the rabbit used (no sign was observed in 2 out of 6 rabbits). Effect of EPA-Ox was more intense than EPA. In an oral test with suckling mice, however, neither of the acids showed a diarrheal effect at a dose of up to 5 mg/mouse. When a very small amount (1.0μg) of okadaic acid (OA) was given, positive toxicity identified as a typical diarrheal substance derived from phytoplanktons. Significant positive correlation (γ=0.984, p<0.01) was obtained between fluid accumulation ratio (FAR) calculated from the result of the loop test in rabbits and percent of dead mice both animals which are usually viewed as a parameter of diarrhea. A large amount of PUFA such as EPA and its oxides is also considered a potential diarrhea inducer, in addition to substances derived from planktons well known for their diarrheal toxin like OA. |
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AbstractList | Since toxic substances and their derivatives are sometimes contained in bivalves, e.g. scallops, eating even a small quantity of those bivalves may cause diarrhea to a human. A thorough study was therefore conducted on the existence of toxic substances in bivalves. A study on the possibility of diarrhea induced by EPA and autoxidized EPA (EPA-Ox; 61.6% decomposition) was conducted using several assays on rabbits and suckling mice. The result of loop test of both EPA and EPA-Ox in rabbit intestine showed positive diarrheal effect at the dose of more than 12.5 mg per loop though the degree of effect depended on the rabbit used (no sign was observed in 2 out of 6 rabbits). Effect of EPA-Ox was more intense than EPA. A study on the possibility of diarrhea induced by EPA and autoxidized EPA (EPA-Ox ; 61.6% decomposition) was conducted using several assays on rabbits and suckling mice. The result of loop test of both EPA and EPA-Ox in rabbit intestine showed positive diarrheal effect at the dose of more than 12.5 mg per loop though the degree of effect depended on the rabbit used (no sign was observed in 2 out of 6 rabbits). Effect of EPA-Ox was more intense than EPA. In an oral test with suckling mice, however, neither of the acids showed a diarrheal effect at a dose of up to 5 mg/mouse. When a very small amount (1.0μg) of okadaic acid (OA) was given, positive toxicity identified as a typical diarrheal substance derived from phytoplanktons. Significant positive correlation (γ=0.984, p<0.01) was obtained between fluid accumulation ratio (FAR) calculated from the result of the loop test in rabbits and percent of dead mice both animals which are usually viewed as a parameter of diarrhea. A large amount of PUFA such as EPA and its oxides is also considered a potential diarrhea inducer, in addition to substances derived from planktons well known for their diarrheal toxin like OA. |
Author | YAMANAKA, TAKAYA MORI, KEIJI HAYASHI, AKIFUMI SAJIKI, JUNKO TAKAHASHI, HARUO TSURUOKA, YOSHIHISA TAKAHASHI, KATSUHIRO |
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Keywords | Edible mollusc Metabolite Toxicity Rodentia Diarrhea Rabbit Toxicity test Lagomorpha Contamination Autoxidation Vertebrata Mammalia Mouse Animal Quality control Digestive diseases Eicosapentaenoic acid Food |
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Snippet | A study on the possibility of diarrhea induced by EPA and autoxidized EPA (EPA-Ox ; 61.6% decomposition) was conducted using several assays on rabbits and... Since toxic substances and their derivatives are sometimes contained in bivalves, e.g. scallops, eating even a small quantity of those bivalves may cause... |
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SubjectTerms | autoxidized EPA Biological and medical sciences diarrheal activity eicosapentaenoic acid (EPA) Food toxicology Medical sciences mouse peritoneal injection test rabbit intestinal loop test suckling mouse diarrheal test Toxicology |
Title | Possibility of Diarrheal Effect by Eicosapentaenoic Acid (EPA) and Autoxidized EPA |
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