Evaluation of intranasal delivery route of drug administration for brain targeting
[Display omitted] •The two main pathways of intranasal drug absorption are the olfactory and trigeminal routes.•The intranasal drugs can bypass the blood-brain barrier and blood-CSF barrier.•There are in vitro, ex vivo and in vivo models for testing drug penetration by intranasal route.•The drug pen...
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| Published in | Brain research bulletin Vol. 143; pp. 155 - 170 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
01.10.2018
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| Subjects | |
| Online Access | Get full text |
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| Abstract | [Display omitted]
•The two main pathways of intranasal drug absorption are the olfactory and trigeminal routes.•The intranasal drugs can bypass the blood-brain barrier and blood-CSF barrier.•There are in vitro, ex vivo and in vivo models for testing drug penetration by intranasal route.•The drug penetartion from nasal cavity can be enhanced by various formulations and devices.•Transporter modulation can also help in nasal delivery of their substrates.
The acute or chronic drug treatments for different neurodegenerative and psychiatric disorders are challenging from several aspects. The low bioavailability and limited brain exposure of oral drugs, the rapid metabolism, elimination, the unwanted side effects and also the high dose to be added mean both inconvenience for the patients and high costs for the patients, their family and the society. The reason of low brain penetration of the compounds is that they have to overcome the blood-brain barrier which protects the brain against xenobiotics. Intranasal drug administration is one of the promising options to bypass blood-brain barrier, to reduce the systemic adverse effects of the drugs and to lower the doses to be administered. Furthermore, the drugs administered using nasal route have usually higher bioavailability, less side effects and result in higher brain exposure at similar dosage than the oral drugs. In this review the focus is on giving an overview on the anatomical and cellular structure of nasal cavity and absorption surface. It presents some possibilities to enhance the drug penetration through the nasal barrier and summarizes some in vitro, ex vivo and in vivo technologies to test the drug delivery across the nasal epithelium into the brain. Finally, the authors give a critical evaluation of the nasal route of administration showing its main advantages and limitations of this delivery route for CNS drug targeting. |
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| AbstractList | [Display omitted]
•The two main pathways of intranasal drug absorption are the olfactory and trigeminal routes.•The intranasal drugs can bypass the blood-brain barrier and blood-CSF barrier.•There are in vitro, ex vivo and in vivo models for testing drug penetration by intranasal route.•The drug penetartion from nasal cavity can be enhanced by various formulations and devices.•Transporter modulation can also help in nasal delivery of their substrates.
The acute or chronic drug treatments for different neurodegenerative and psychiatric disorders are challenging from several aspects. The low bioavailability and limited brain exposure of oral drugs, the rapid metabolism, elimination, the unwanted side effects and also the high dose to be added mean both inconvenience for the patients and high costs for the patients, their family and the society. The reason of low brain penetration of the compounds is that they have to overcome the blood-brain barrier which protects the brain against xenobiotics. Intranasal drug administration is one of the promising options to bypass blood-brain barrier, to reduce the systemic adverse effects of the drugs and to lower the doses to be administered. Furthermore, the drugs administered using nasal route have usually higher bioavailability, less side effects and result in higher brain exposure at similar dosage than the oral drugs. In this review the focus is on giving an overview on the anatomical and cellular structure of nasal cavity and absorption surface. It presents some possibilities to enhance the drug penetration through the nasal barrier and summarizes some in vitro, ex vivo and in vivo technologies to test the drug delivery across the nasal epithelium into the brain. Finally, the authors give a critical evaluation of the nasal route of administration showing its main advantages and limitations of this delivery route for CNS drug targeting. The acute or chronic drug treatments for different neurodegenerative and psychiatric disorders are challenging from several aspects. The low bioavailability and limited brain exposure of oral drugs, the rapid metabolism, elimination, the unwanted side effects and also the high dose to be added mean both inconvenience for the patients and high costs for the patients, their family and the society. The reason of low brain penetration of the compounds is that they have to overcome the blood-brain barrier which protects the brain against xenobiotics. Intranasal drug administration is one of the promising options to bypass blood-brain barrier, to reduce the systemic adverse effects of the drugs and to lower the doses to be administered. Furthermore, the drugs administered using nasal route have usually higher bioavailability, less side effects and result in higher brain exposure at similar dosage than the oral drugs. In this review the focus is on giving an overview on the anatomical and cellular structure of nasal cavity and absorption surface. It presents some possibilities to enhance the drug penetration through the nasal barrier and summarizes some in vitro, ex vivo and in vivo technologies to test the drug delivery across the nasal epithelium into the brain. Finally, the authors give a critical evaluation of the nasal route of administration showing its main advantages and limitations of this delivery route for CNS drug targeting. |
| Author | Farkas, Dániel Bajza, Ágnes Erdő, Franciska Gizurarson, Sveinbjörn Bors, Luca Anna |
| Author_xml | – sequence: 1 givenname: Franciska surname: Erdő fullname: Erdő, Franciska email: erdo.franciska@itk.ppke.hu organization: Faculty of Information Technology and Bionics, Pázmány Péter Catholic University, Práter u. 50A, H-1083 Budapest, Hungary – sequence: 2 givenname: Luca Anna surname: Bors fullname: Bors, Luca Anna organization: Faculty of Information Technology and Bionics, Pázmány Péter Catholic University, Práter u. 50A, H-1083 Budapest, Hungary – sequence: 3 givenname: Dániel surname: Farkas fullname: Farkas, Dániel organization: Faculty of Information Technology and Bionics, Pázmány Péter Catholic University, Práter u. 50A, H-1083 Budapest, Hungary – sequence: 4 givenname: Ágnes surname: Bajza fullname: Bajza, Ágnes organization: Faculty of Information Technology and Bionics, Pázmány Péter Catholic University, Práter u. 50A, H-1083 Budapest, Hungary – sequence: 5 givenname: Sveinbjörn orcidid: 0000-0001-7824-9752 surname: Gizurarson fullname: Gizurarson, Sveinbjörn organization: Faculty of Pharmaceutical Sciences, University of Iceland, Hofsvallagata 53, 107 Reykjavík, Iceland |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30449731$$D View this record in MEDLINE/PubMed |
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•The two main pathways of intranasal drug absorption are the olfactory and trigeminal routes.•The intranasal drugs can bypass the blood-brain... The acute or chronic drug treatments for different neurodegenerative and psychiatric disorders are challenging from several aspects. The low bioavailability... |
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| SubjectTerms | CNS indication Delivery enhancer techniques Drug delivery Intranasal administration Transporter interactions |
| Title | Evaluation of intranasal delivery route of drug administration for brain targeting |
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