Sonic Hedgehog Pathway Promotes Metastasis and Lymphangiogenesis via Activation of Akt, EMT, and MMP-9 Pathway in Gastric Cancer

• Published in: Cancer research (Chicago, Ill.) Vol. 71; no. 22; pp. 7061 - 7070
• Main Authors: YOO, Young A, MYOUNG HEE KANG, HYUN JOO LEE, KIM, Baek-Hui, JONG KUK PARK, HYUN KOO KIM, JUN SUK KIM, SANG CHEUL OH
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 15.11.2011
• Subjects: Adult; Aged; Animals; Antineoplastic agents; Biological and medical sciences; Cell Line, Tumor; Epithelial-Mesenchymal Transition; Female; Gastroenterology. Liver. Pancreas. Abdomen; Hedgehog Proteins - analysis; Hedgehog Proteins - physiology; Humans; Lymphangiogenesis; Lymphatic Metastasis; Male; Matrix Metalloproteinase 9 - physiology; Medical sciences; Mice; Mice, Inbred BALB C; Middle Aged; Pharmacology. Drug treatments; Phosphatidylinositol 3-Kinases - physiology; Proto-Oncogene Proteins c-akt - physiology; Signal Transduction - physiology; Stomach Neoplasms - pathology; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Tumors; Enzyme; Akt protein kinase; Metalloendopeptidases; Activation; Malignant tumor; Metastasis; Stomach cancer; Gelatinase B; Cell signaling; Peptidases; Regulation(control); Hedgehog protein; Hydrolases; Digestive diseases; Lymphangiogenesis; Cancer; Gastric disease

Activation of sonic hedgehog (Shh) signaling has been implicated in progression of a variety of tumors. In this study, we elucidated a role for Shh in the invasion of gastric tumors and determined the mechanism by which Shh is regulated. Immunohistochemical analysis of 178 primary human gastric tumo...