Surfactant protein D inhibits growth, alters cell surface polysaccharide exposure and immune activation potential of Aspergillus fumigatus

• Published in: Cell surface (Amsterdam) Vol. 8; p. 100072
• Main Authors: Wong, Sarah Sze Wah, Dellière, Sarah, Schiefermeier-Mach, Natalia, Lechner, Lukas, Perkhofer, Susanne, Bomme, Perrine, Fontaine, Thierry, Schlosser, Anders G., Sorensen, Grith L., Madan, Taruna, Kishore, Uday, Aimanianda, Vishukumar
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.12.2022; Elsevier
• Subjects: Aspergillus fumigatus; Cell wall; Innate immunity; Life Sciences; Microbiology and Parasitology; Mycology; Pattern-recognition receptor; Polysaccharides; Surfactant protein D; SP-D; Polysaccharides; IL; Surfactant protein D; GM; Innate immunity; GAG; Aspergillus fumigatus; PBMCs; Pattern-recognition receptor; Cell wall; GAG:, Galactosaminogalactan; GM:, Galactomannan; PBMCs:, Peripheral blood mononuclear cells; SP-D:, Surfactant protein-D; IL:, Interleukin

•Surfactant protein D (SP-D), a C-type lectin and a major humoral immune component in the human lung-alveoli, shows direct growth inhibitory effect on Aspergillus fumigatus, an airborne opportunistic fungal pathogen.•SP-D treatment modifies the surface architecture and cell wall polysaccharide expos...