Pigment epithelium-derived factor inhibits lung cancer migration and invasion by upregulating exosomal thrombospondin 1

Exosomes are implicated in cancer cell development, migration and invasion. Pigment epithelium-derived factor (PEDF) is a secreted anticancer protein that can regulate lung cancer progression; however, the role of PEDF in non-small cell lung cancer (NSCLC), including metastasis and cancer cell-deriv...

Full description

Saved in:

Bibliographic Details
Published in	Cancer letters Vol. 442; pp. 287 - 298
Main Authors	Huang, Wen-Tsung, Chong, Inn-Wen, Chen, Hsiu-Lin, Li, Chia-Yang, Hsieh, Chong-Chao, Kuo, Hsuan-Fu, Chang, Chia-Yuan, Chen, Yung-Hsiang, Liu, Yu-Peng, Lu, Chi-Yu, Liu, Yu-Ru, Liu, Po-Len
Format	Journal Article
Language	English
Published	Ireland Elsevier B.V 01.02.2019 Elsevier Limited
Subjects	Alpha-smooth muscle actin Angiogenesis Cell adhesion & migration Cell aggregation Cell migration Cytoskeletal remodeling Cytoskeleton Epithelium Exosome Exosomes Invasion Lung cancer Metastases Metastasis Microscopy Migration Motility Non-small cell lung cancer Non-small cell lung carcinoma NSCLC PEDF Pigment epithelium-derived factor Proteins Secretion THBS1 Thrombospondin Thrombospondin 1 Tumorigenicity Xenografts α-SMA United States > US Germany Taiwan α-SMA PEDF NSCLC Exosome Migration Non-small cell lung cancer Alpha-smooth muscle actin Cytoskeletal remodeling Pigment epithelium-derived factor THBS1 Thrombospondin 1 Invasion
Online Access	Get full text

Cover

Loading…

Abstract	Exosomes are implicated in cancer cell development, migration and invasion. Pigment epithelium-derived factor (PEDF) is a secreted anticancer protein that can regulate lung cancer progression; however, the role of PEDF in non-small cell lung cancer (NSCLC), including metastasis and cancer cell-derived exosome secretion, is unclear. In this study, we analyzed the effects of PEDF on exosome-mediated migration, invasion, and tumorigenicity of cultured NSCLC cells. The results showed that PEDF overexpression significantly reduced NSCLC invasion and migration, while inducing cell aggregation, whereas PEDF knockdown had the opposite effects. Exosomes from NSCLC cells treated with recombinant PEDF had a significantly reduced ability to promote cancer cell motility, migration, and invasion compared to exosomes from untreated cells. Exosomes from PEDF-treated cells contained thrombospondin 1 (THBS1), which inhibited cytoskeletal remodeling and exosome-induced lung cancer cell motility, migration, and invasion. Furthermore, PEDF-overexpressing NSCLC cells formed smaller xenograft tumors with higher THBS1 expression compared to control tumors. Our findings indicate that PEDF decreases the metastatic potential of NSCLC cells through regulation of THBS1 release in cancer cell-derived exosomes, thus uncovering a new mechanism of lung cancer progression. •PEDF induces aggregation and reduces invasion and migration of lung cancer cells.•Exosomes from PEDF-treated cancer cells inhibit metastatic behavior of NSCLC cells.•PEDF-expressing NSCLC cells have reduced tumorigenicity in vivo.•PEDF increases thrombospondin 1 content in lung cancer cell-derived exosomes.•Thrombospondin 1 inhibits exosome-induced lung cancer cell migration and invasion.
AbstractList	Exosomes are implicated in cancer cell development, migration and invasion. Pigment epithelium-derived factor (PEDF) is a secreted anticancer protein that can regulate lung cancer progression; however, the role of PEDF in non-small cell lung cancer (NSCLC), including metastasis and cancer cell-derived exosome secretion, is unclear. In this study, we analyzed the effects of PEDF on exosome-mediated migration, invasion, and tumorigenicity of cultured NSCLC cells. The results showed that PEDF overexpression significantly reduced NSCLC invasion and migration, while inducing cell aggregation, whereas PEDF knockdown had the opposite effects. Exosomes from NSCLC cells treated with recombinant PEDF had a significantly reduced ability to promote cancer cell motility, migration, and invasion compared to exosomes from untreated cells. Exosomes from PEDF-treated cells contained thrombospondin 1 (THBS1), which inhibited cytoskeletal remodeling and exosome-induced lung cancer cell motility, migration, and invasion. Furthermore, PEDF-overexpressing NSCLC cells formed smaller xenograft tumors with higher THBS1 expression compared to control tumors. Our findings indicate that PEDF decreases the metastatic potential of NSCLC cells through regulation of THBS1 release in cancer cell-derived exosomes, thus uncovering a new mechanism of lung cancer progression. •PEDF induces aggregation and reduces invasion and migration of lung cancer cells.•Exosomes from PEDF-treated cancer cells inhibit metastatic behavior of NSCLC cells.•PEDF-expressing NSCLC cells have reduced tumorigenicity in vivo.•PEDF increases thrombospondin 1 content in lung cancer cell-derived exosomes.•Thrombospondin 1 inhibits exosome-induced lung cancer cell migration and invasion. Exosomes are implicated in cancer cell development, migration and invasion. Pigment epithelium-derived factor (PEDF) is a secreted anticancer protein that can regulate lung cancer progression; however, the role of PEDF in non-small cell lung cancer (NSCLC), including metastasis and cancer cell-derived exosome secretion, is unclear. In this study, we analyzed the effects of PEDF on exosome-mediated migration, invasion, and tumorigenicity of cultured NSCLC cells. The results showed that PEDF overexpression significantly reduced NSCLC invasion and migration, while inducing cell aggregation, whereas PEDF knockdown had the opposite effects. Exosomes from NSCLC cells treated with recombinant PEDF had a significantly reduced ability to promote cancer cell motility, migration, and invasion compared to exosomes from untreated cells. Exosomes from PEDF-treated cells contained thrombospondin 1 (THBS1), which inhibited cytoskeletal remodeling and exosome-induced lung cancer cell motility, migration, and invasion. Furthermore, PEDF-overexpressing NSCLC cells formed smaller xenograft tumors with higher THBS1 expression compared to control tumors. Our findings indicate that PEDF decreases the metastatic potential of NSCLC cells through regulation of THBS1 release in cancer cell-derived exosomes, thus uncovering a new mechanism of lung cancer progression.Exosomes are implicated in cancer cell development, migration and invasion. Pigment epithelium-derived factor (PEDF) is a secreted anticancer protein that can regulate lung cancer progression; however, the role of PEDF in non-small cell lung cancer (NSCLC), including metastasis and cancer cell-derived exosome secretion, is unclear. In this study, we analyzed the effects of PEDF on exosome-mediated migration, invasion, and tumorigenicity of cultured NSCLC cells. The results showed that PEDF overexpression significantly reduced NSCLC invasion and migration, while inducing cell aggregation, whereas PEDF knockdown had the opposite effects. Exosomes from NSCLC cells treated with recombinant PEDF had a significantly reduced ability to promote cancer cell motility, migration, and invasion compared to exosomes from untreated cells. Exosomes from PEDF-treated cells contained thrombospondin 1 (THBS1), which inhibited cytoskeletal remodeling and exosome-induced lung cancer cell motility, migration, and invasion. Furthermore, PEDF-overexpressing NSCLC cells formed smaller xenograft tumors with higher THBS1 expression compared to control tumors. Our findings indicate that PEDF decreases the metastatic potential of NSCLC cells through regulation of THBS1 release in cancer cell-derived exosomes, thus uncovering a new mechanism of lung cancer progression. Exosomes are implicated in cancer cell development, migration and invasion. Pigment epithelium-derived factor (PEDF) is a secreted anticancer protein that can regulate lung cancer progression; however, the role of PEDF in non-small cell lung cancer (NSCLC), including metastasis and cancer cell-derived exosome secretion, is unclear. In this study, we analyzed the effects of PEDF on exosome-mediated migration, invasion, and tumorigenicity of cultured NSCLC cells. The results showed that PEDF overexpression significantly reduced NSCLC invasion and migration, while inducing cell aggregation, whereas PEDF knockdown had the opposite effects. Exosomes from NSCLC cells treated with recombinant PEDF had a significantly reduced ability to promote cancer cell motility, migration, and invasion compared to exosomes from untreated cells. Exosomes from PEDF-treated cells contained thrombospondin 1 (THBS1), which inhibited cytoskeletal remodeling and exosome-induced lung cancer cell motility, migration, and invasion. Furthermore, PEDF-overexpressing NSCLC cells formed smaller xenograft tumors with higher THBS1 expression compared to control tumors. Our findings indicate that PEDF decreases the metastatic potential of NSCLC cells through regulation of THBS1 release in cancer cell-derived exosomes, thus uncovering a new mechanism of lung cancer progression.
Author	Huang, Wen-Tsung Kuo, Hsuan-Fu Chong, Inn-Wen Liu, Yu-Peng Chang, Chia-Yuan Liu, Po-Len Liu, Yu-Ru Hsieh, Chong-Chao Li, Chia-Yang Lu, Chi-Yu Chen, Hsiu-Lin Chen, Yung-Hsiang
Author_xml	– sequence: 1 givenname: Wen-Tsung surname: Huang fullname: Huang, Wen-Tsung organization: Division of Hemato-oncology, Department of Internal Medicine, Chi Mei Medical Center, Liouying, Tainan 736, Taiwan – sequence: 2 givenname: Inn-Wen surname: Chong fullname: Chong, Inn-Wen organization: Department of Respiratory Therapy, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan – sequence: 3 givenname: Hsiu-Lin surname: Chen fullname: Chen, Hsiu-Lin organization: Department of Respiratory Therapy, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan – sequence: 4 givenname: Chia-Yang surname: Li fullname: Li, Chia-Yang organization: Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, 807, Taiwan – sequence: 5 givenname: Chong-Chao surname: Hsieh fullname: Hsieh, Chong-Chao organization: Division of Cardiovascular Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan – sequence: 6 givenname: Hsuan-Fu surname: Kuo fullname: Kuo, Hsuan-Fu organization: Department of Internal Medicine, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 801, Taiwan – sequence: 7 givenname: Chia-Yuan orcidid: 0000-0003-0587-0868 surname: Chang fullname: Chang, Chia-Yuan organization: Center for Micro/Nano Science and Technology, National Cheng Kung University, Tainan 701, Taiwan – sequence: 8 givenname: Yung-Hsiang surname: Chen fullname: Chen, Yung-Hsiang organization: Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, Taichung 404, Taiwan – sequence: 9 givenname: Yu-Peng surname: Liu fullname: Liu, Yu-Peng organization: Graduate Institute of Clinical Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan – sequence: 10 givenname: Chi-Yu surname: Lu fullname: Lu, Chi-Yu organization: Department of Biochemistry, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan – sequence: 11 givenname: Yu-Ru surname: Liu fullname: Liu, Yu-Ru organization: Department of Respiratory Therapy, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan – sequence: 12 givenname: Po-Len orcidid: 0000-0003-2896-1666 surname: Liu fullname: Liu, Po-Len email: kisa@kmu.edu.tw organization: Department of Respiratory Therapy, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/30439539$$D View this record in MEDLINE/PubMed
BookMark	eNqFkUtvEzEUhS1URNPCP0DIEhs2E-xxPA-EKqGqPKRKsOje8njuJDd47GB7Avn39ZDCIpvIC8vH3zm27rkiF847IOQ1Z0vOePV-uzTaWUjLkvEmS0sm-DOy4E1dFnXbsAuyYIKtCtEIeUmuYtwyxuSqli_IZdZFK0W7IL9_4HoElyjsMG3A4jQWPQTcQ08HbZIPFN0GO0yR2smtaX7UQKAjroNO6B3Vrs_IXsf50B3otAuwnmy-zDT88dGP2tK0CX7sfNx516Oj_CV5Pmgb4dXTfk0ePt893H4t7r9_-Xb76b4wUspUcNOYUpai4kJAqaWpO9M2pWmkYVVXr3TPWaX5MGgG7cA6aSrelh1r5FAPphbX5N0xdhf8rwliUiNGA9ZqB36KquRC8pzOWEbfnqBbPwWXP5epitV58TnwzRM1dSP0ahdw1OGg_k00A6sjYIKPMcDwH-FMzcWprToWp-biZjUXl20fTmwG098Bp6DRnjPfHM2QJ7lHCCoahNxTjwFMUr3HcwEfTwKMRYdG259wOG9_BFvyy_c
CitedBy_id	crossref_primary_10_3390_jcm10173859 crossref_primary_10_3390_life12081250 crossref_primary_10_3390_ph16060789 crossref_primary_10_1016_j_canlet_2023_216400 crossref_primary_10_1016_j_prp_2021_153454 crossref_primary_10_1186_s12920_020_00799_6 crossref_primary_10_3390_ijms22094570 crossref_primary_10_1016_j_biochi_2022_05_019 crossref_primary_10_1039_D2NH00570K crossref_primary_10_1016_j_bcp_2022_115013 crossref_primary_10_2174_1568009623666230227162532 crossref_primary_10_3389_fphar_2021_734443 crossref_primary_10_3390_ijms22073628 crossref_primary_10_2174_1381612825666190319112106 crossref_primary_10_3390_cancers16223768 crossref_primary_10_3389_fonc_2020_01728 crossref_primary_10_1167_iovs_62_7_18 crossref_primary_10_1097_CAD_0000000000001194 crossref_primary_10_1111_bph_16232 crossref_primary_10_2174_1381612826666200128091506 crossref_primary_10_1096_fj_202001106RRR crossref_primary_10_2147_OTT_S231914 crossref_primary_10_1080_07391102_2022_2069863 crossref_primary_10_1016_j_biopha_2022_112771 crossref_primary_10_1016_j_ijpharm_2019_118999 crossref_primary_10_1016_j_repbio_2021_100576 crossref_primary_10_3390_biomedicines11041070 crossref_primary_10_1186_s12943_021_01411_w crossref_primary_10_2174_1871520621666210301085318 crossref_primary_10_1186_s12967_021_02985_1 crossref_primary_10_3892_ol_2021_13094 crossref_primary_10_1016_j_critrevonc_2022_103603 crossref_primary_10_3389_fmolb_2024_1414164 crossref_primary_10_1038_s41598_025_86003_0 crossref_primary_10_3389_fgene_2020_00955 crossref_primary_10_1039_D0AY02074E crossref_primary_10_1146_annurev_animal_111523_102021 crossref_primary_10_1016_j_bcp_2021_114787 crossref_primary_10_1155_2021_5563746 crossref_primary_10_1158_0008_5472_CAN_20_2756 crossref_primary_10_1016_j_jtos_2023_12_002 crossref_primary_10_3390_cancers13061351 crossref_primary_10_1155_2022_3188992 crossref_primary_10_1016_j_ebiom_2019_11_003 crossref_primary_10_1097_CCO_0000000000000913 crossref_primary_10_1007_s00018_019_03233_y crossref_primary_10_3389_fonc_2020_557730 crossref_primary_10_1007_s12672_022_00541_x crossref_primary_10_1016_j_bbcan_2025_189273 crossref_primary_10_1016_j_yexcr_2024_114393 crossref_primary_10_3390_biology14020155
Cites_doi	10.1016/j.mvr.2006.02.004 10.1038/s41467-017-01433-3 10.1002/ijc.24373 10.1038/nrc3490 10.18632/oncotarget.20458 10.18632/oncotarget.18373 10.1371/journal.pone.0161007 10.18632/oncotarget.19165 10.1074/jbc.M114.590000 10.1158/0008-5472.CAN-04-0230 10.1371/journal.pone.0156059 10.1038/onc.2016.253 10.1182/blood-2004-04-1569 10.1002/ijc.29562 10.1038/onc.2017.105 10.1016/S0006-291X(02)00180-8 10.3322/caac.21332 10.1042/bse0330149 10.1016/j.canlet.2018.06.002 10.1165/rcmb.2003-0238OC 10.1073/pnas.1004934107 10.3892/ol.2016.5316 10.18632/oncotarget.24953 10.1016/j.canlet.2016.07.023 10.1016/j.jip.2018.04.004 10.21037/tlcr.2016.10.07 10.1016/S0304-3835(03)00185-X 10.1055/s-2004-822977 10.1007/s10549-014-3154-9 10.1186/s12885-016-2541-5 10.1080/15384047.2016.1156273 10.1373/clinchem.2008.112797 10.1002/1521-4141(200204)32:4<1069::AID-IMMU1069>3.0.CO;2-E 10.18632/oncotarget.10243 10.1016/j.cub.2018.01.059 10.1152/ajpcell.00004.2017 10.1074/jbc.274.16.11408 10.1021/acs.analchem.7b04861 10.1016/j.ccell.2016.10.009
ContentType	Journal Article
Copyright	2018 The Author(s) Copyright © 2018 The Author(s). Published by Elsevier B.V. All rights reserved. Copyright Elsevier Limited Feb 1, 2019
Copyright_xml	– notice: 2018 The Author(s) – notice: Copyright © 2018 The Author(s). Published by Elsevier B.V. All rights reserved. – notice: Copyright Elsevier Limited Feb 1, 2019
DBID	6I. AAFTH AAYXX CITATION NPM 7TO 7U9 H94 K9. NAPCQ 7X8
DOI	10.1016/j.canlet.2018.10.031
DatabaseName	ScienceDirect Open Access Titles Elsevier:ScienceDirect:Open Access CrossRef PubMed Oncogenes and Growth Factors Abstracts Virology and AIDS Abstracts AIDS and Cancer Research Abstracts ProQuest Health & Medical Complete (Alumni) Nursing & Allied Health Premium MEDLINE - Academic
DatabaseTitle	CrossRef PubMed AIDS and Cancer Research Abstracts ProQuest Health & Medical Complete (Alumni) Nursing & Allied Health Premium Virology and AIDS Abstracts Oncogenes and Growth Factors Abstracts MEDLINE - Academic
DatabaseTitleList	MEDLINE - Academic PubMed AIDS and Cancer Research Abstracts
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Medicine
EISSN	1872-7980
EndPage	298
ExternalDocumentID	30439539 10_1016_j_canlet_2018_10_031 S0304383518306463
Genre	Journal Article
GeographicLocations	United States--US Germany Taiwan
GeographicLocations_xml	– name: Taiwan – name: United States--US – name: Germany
GroupedDBID	--- --K --M .1- .FO .~1 0R~ 1B1 1P~ 1RT 1~. 1~5 29B 4.4 457 4CK 4G. 5GY 5RE 5VS 6J9 6PF 7-5 71M 8FE 8FH 8P~ 9JM AABNK AAEDT AAEDW AAIKJ AAKOC AALRI AAOAW AAQFI AATTM AAWTL AAXKI AAXUO AAYWO ABBQC ABFNM ABFRF ABGSF ABJNI ABMAC ABMZM ABUDA ACDAQ ACGFO ACGFS ACIEU ACIUM ACPRK ACRLP ACVFH ADBBV ADCNI ADEZE ADFRT ADUVX AEBSH AEFWE AEHWI AEIPS AEKER AENEX AEUPX AEVXI AFPUW AFRAH AFRHN AFTJW AFXIZ AGCQF AGHFR AGUBO AGYEJ AHHHB AHMBA AIEXJ AIIUN AIKHN AITUG AJRQY AJUYK AKBMS AKRWK AKYEP ALMA_UNASSIGNED_HOLDINGS AMRAJ ANKPU ANZVX APXCP AXJTR BKEYQ BKOJK BLXMC BNPGV BPHCQ BVXVI CS3 DU5 EBS EFJIC EFKBS EJD EO8 EO9 EP2 EP3 F5P FDB FIRID FNPLU FYGXN G-Q GBLVA IH2 IHE J1W K-O KOM LK8 M29 M41 MO0 N9A O-L O9- OAUVE OC~ OO- OZT P-8 P-9 P2P PC. PQQKQ PROAC Q38 ROL RPZ SCC SDF SDG SDP SEL SES SPCBC SSH SSU SSZ T5K Z5R ~G- 3V. 6I. 7RV 7X7 8C1 8FI AACTN AAFTH AAIAV ABLVK ABYKQ AFCTW AFKRA AFKWA AJOXV AMFUW AZQEC BBNVY BENPR BHPHI DOVZS EFLBG FYUFA GUQSH HCIFZ LCYCR M1P M2M M2O M7P RIG .55 .GJ 3O- 53G AAQXK AAYXX ABWVN ABXDB ACRPL ADMUD ADNMO AFFNX AFJKZ AGQPQ AGRDE AGRNS AI. AIGII ASPBG AVWKF AZFZN CITATION FEDTE FGOYB G-2 HED HMK HMO HVGLF HZ~ R2- SAE SEW UDS VH1 WUQ X7M ZGI NPM 7TO 7U9 H94 K9. NAPCQ 7X8
ID	FETCH-LOGICAL-c555t-1c8c25236133e2a5c7bc982c85c06b74ad106a1ffa0e9f0b5c6192b085f7fc73
IEDL.DBID	.~1
ISSN	0304-3835 1872-7980
IngestDate	Fri Jul 11 09:59:39 EDT 2025 Wed Aug 13 02:34:06 EDT 2025 Mon Jul 21 05:30:39 EDT 2025 Tue Jul 01 02:29:38 EDT 2025 Thu Apr 24 23:12:24 EDT 2025 Fri Feb 23 02:33:50 EST 2024 Tue Aug 26 16:33:35 EDT 2025
IsDoiOpenAccess	true
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Keywords	α-SMA PEDF NSCLC Exosome Migration Non-small cell lung cancer Alpha-smooth muscle actin Cytoskeletal remodeling Pigment epithelium-derived factor THBS1 Thrombospondin 1 Invasion
Language	English
License	This is an open access article under the CC BY-NC-ND license. Copyright © 2018 The Author(s). Published by Elsevier B.V. All rights reserved.
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c555t-1c8c25236133e2a5c7bc982c85c06b74ad106a1ffa0e9f0b5c6192b085f7fc73
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
ORCID	0000-0003-2896-1666 0000-0003-0587-0868
OpenAccessLink	https://www.sciencedirect.com/science/article/pii/S0304383518306463
PMID	30439539
PQID	2160707017
PQPubID	2031080
PageCount	12
ParticipantIDs	proquest_miscellaneous_2135136100 proquest_journals_2160707017 pubmed_primary_30439539 crossref_primary_10_1016_j_canlet_2018_10_031 crossref_citationtrail_10_1016_j_canlet_2018_10_031 elsevier_sciencedirect_doi_10_1016_j_canlet_2018_10_031 elsevier_clinicalkey_doi_10_1016_j_canlet_2018_10_031
ProviderPackageCode	CITATION AAYXX
PublicationCentury	2000
PublicationDate	2019-02-01
PublicationDateYYYYMMDD	2019-02-01
PublicationDate_xml	– month: 02 year: 2019 text: 2019-02-01 day: 01
PublicationDecade	2010
PublicationPlace	Ireland
PublicationPlace_xml	– name: Ireland – name: Clare
PublicationTitle	Cancer letters
PublicationTitleAlternate	Cancer Lett
PublicationYear	2019
Publisher	Elsevier B.V Elsevier Limited
Publisher_xml	– name: Elsevier B.V – name: Elsevier Limited
References	Fang, Duan, Adkins, Pan, Wang, Liu, Zhong (bib23) 2018; 90 Bueno-Pallero, Blanco-Perez, Dionisio, Campos-Herrera (bib28) 2018; 154 Sargiannidou, Qiu, Tuszynski (bib36) 2004; 30 Huang, Sun, Yuan, Qiu (bib40) 2017; 8 Li, Yao, Fang, Ma, Cen, Xu, Dai, Li, Li, Zhang, Hong, Qi, Zhou, Li, Yang, Gao (bib33) 2014; 289 Siegel, Miller, Jemal (bib2) 2016; 66 Kuo, Liu, Chong, Liu, Chen, Ku, Li, Chen, Chiang, Wang, Chen, Chen, Hsieh (bib22) 2016; 11 Maik-Rachline, Shaltiel, Seger (bib34) 2005; 105 Decker, van Valen, Vischer (bib37) 2002; 293 Farnoodian, Kinter, Yadranji Aghdam, Zaitoun, Sorenson, Sheibani (bib19) 2015; 3 Nucera, Porrello, Antonello, Mekel, Nehs, Giordano, Gerald, Benjamin, Priolo, Puxeddu, Finn, Jarzab, Hodin, Pontecorvi, Nose, Lawler, Parangi (bib39) 2010; 107 Falero-Perez, Park, Sorenson, Sheibani (bib16) 2017; 313 Garcia, Fernandez-Garcia, Rivas, Carretero, Escamez, Gonzalez-Martin, Medrano, Volpert, Jorcano, Jimenez, Larcher, Del Rio (bib24) 2004; 64 Lv, Sun, Shi, Shi, Qin, Li (bib11) 2016; 12 Liu, Liu, Chang, Chen, Liu, Kuo, Hsieh, Ding, Chen, Chong (bib20) 2017; 12 Plebanek, Angeloni, Vinokour, Li, Henkin, Martinez-Marin, Filleur, Bhowmick, Henkin, Miller, Ifergan, Lee, Osman, Thaxton, Volpert (bib13) 2017; 8 Xu, Wang, Zhang, Chen, Gu, Dou, Xia, Bi, Fan (bib14) 2017; 8 Harries, Owen, Ruge, Morgan, Li, Zhang, Harding, Torkington, Jiang, Cai (bib32) 2018; 9 Marciniak, Butwicka, Nowak (bib8) 2006; 60 Ong, Wang, Chia, Seah, Kong, Thuya, Chinnathambi, Lau, Wong, Yong, Yang, Ho, Sethi, Goh (bib1) 2016; 381 Lunkes, Trottier, Mandel (bib4) 1998; 33 Tsai, Shih, Ho, Ma, Liu, Chen, Tsao (bib27) 2014; 9 Natale, Bocci (bib15) 2018; 432 Chandrasekaran, Guo, Rodrigues, Kaiser, Roberts (bib29) 1999; 274 Meldolesi (bib3) 2018; 28 Hong, Zhou, Fang, Jia, Xu, Dai, Li, Li, Li, Zhang, Qi, Bardeesi, Yang, Cai, Yang, Gao (bib30) 2014; 148 Chen, Li, He, Mao, Li, Lyu, Meng (bib12) 2016; 17 Weng, Wang, Hung, Chen, Chen, Lai (bib17) 2016; 11 Becker, Thakur, Weiss, Kim, Peinado, Lyden (bib26) 2016; 30 Rahman, Barger, Lovat, Gao, Otterson, Nana-Sinkam (bib5) 2016; 7 Bustin, Benes, Garson, Hellemans, Huggett, Kubista, Mueller, Nolan, Pfaffl, Shipley, Vandesompele, Wittwer (bib21) 2009; 55 Rouanne, Adam, Goubar, Robin, Ohana, Louvet, Cormier, Mercier, Dorfmuller, Fattal, de Montpreville, Lebret, Dartevelle, Fadel, Besse, Olaussen, Auclair, Soria (bib41) 2016; 16 Wendler, Favicchio, Simon, Alifrangis, Stebbing, Giamas (bib25) 2017; 36 Alderton (bib10) 2013; 13 Hsu, Hung, Chang, Lin, Pan, Tsai, Wu, Kuo (bib6) 2017; 36 Wang, Yang, Zhu, Wang, Wang, Bai, Sun, Peng, Wei, Chen, Li, Zamyatnin, Glybochko, Xu (bib31) 2017; 8 Bard, Hegmans, Hemmes, Luider, Willemsen, Severijnen, van Meerbeeck, Burgers, Hoogsteden, Lambrecht (bib35) 2004; 31 Perez-Callejo, Romero, Provencio, Torrente (bib7) 2016; 5 Li, Ivanoff, Bergstrom, Sandstrom, Christensson, van Nerven, Holgersson, Hauzenberger, Arencibia, Sundqvist (bib42) 2002; 32 Hyder, Liang, Wu (bib38) 2009; 125 Chan, Zhang, Liu, Tsao, Lung, Mak, Ngok-Shun Wong, Ying-Kit Yue (bib18) 2015; 137 Miyagishi, Ohno-Matsui, Amagasa, Morita (bib9) 2003; 196 Wang, Wang, Sheibani (bib43) 2006; 71 Farnoodian (10.1016/j.canlet.2018.10.031_bib19) 2015; 3 Rouanne (10.1016/j.canlet.2018.10.031_bib41) 2016; 16 Li (10.1016/j.canlet.2018.10.031_bib33) 2014; 289 Wang (10.1016/j.canlet.2018.10.031_bib31) 2017; 8 Weng (10.1016/j.canlet.2018.10.031_bib17) 2016; 11 Meldolesi (10.1016/j.canlet.2018.10.031_bib3) 2018; 28 Harries (10.1016/j.canlet.2018.10.031_bib32) 2018; 9 Alderton (10.1016/j.canlet.2018.10.031_bib10) 2013; 13 Ong (10.1016/j.canlet.2018.10.031_bib1) 2016; 381 Bueno-Pallero (10.1016/j.canlet.2018.10.031_bib28) 2018; 154 Bard (10.1016/j.canlet.2018.10.031_bib35) 2004; 31 Plebanek (10.1016/j.canlet.2018.10.031_bib13) 2017; 8 Sargiannidou (10.1016/j.canlet.2018.10.031_bib36) 2004; 30 Hsu (10.1016/j.canlet.2018.10.031_bib6) 2017; 36 Rahman (10.1016/j.canlet.2018.10.031_bib5) 2016; 7 Lv (10.1016/j.canlet.2018.10.031_bib11) 2016; 12 Garcia (10.1016/j.canlet.2018.10.031_bib24) 2004; 64 Natale (10.1016/j.canlet.2018.10.031_bib15) 2018; 432 Chandrasekaran (10.1016/j.canlet.2018.10.031_bib29) 1999; 274 Li (10.1016/j.canlet.2018.10.031_bib42) 2002; 32 Kuo (10.1016/j.canlet.2018.10.031_bib22) 2016; 11 Perez-Callejo (10.1016/j.canlet.2018.10.031_bib7) 2016; 5 Maik-Rachline (10.1016/j.canlet.2018.10.031_bib34) 2005; 105 Chan (10.1016/j.canlet.2018.10.031_bib18) 2015; 137 Chen (10.1016/j.canlet.2018.10.031_bib12) 2016; 17 Becker (10.1016/j.canlet.2018.10.031_bib26) 2016; 30 Marciniak (10.1016/j.canlet.2018.10.031_bib8) 2006; 60 Hyder (10.1016/j.canlet.2018.10.031_bib38) 2009; 125 Huang (10.1016/j.canlet.2018.10.031_bib40) 2017; 8 Falero-Perez (10.1016/j.canlet.2018.10.031_bib16) 2017; 313 Decker (10.1016/j.canlet.2018.10.031_bib37) 2002; 293 Tsai (10.1016/j.canlet.2018.10.031_bib27) 2014; 9 Bustin (10.1016/j.canlet.2018.10.031_bib21) 2009; 55 Hong (10.1016/j.canlet.2018.10.031_bib30) 2014; 148 Miyagishi (10.1016/j.canlet.2018.10.031_bib9) 2003; 196 Xu (10.1016/j.canlet.2018.10.031_bib14) 2017; 8 Liu (10.1016/j.canlet.2018.10.031_bib20) 2017; 12 Wendler (10.1016/j.canlet.2018.10.031_bib25) 2017; 36 Nucera (10.1016/j.canlet.2018.10.031_bib39) 2010; 107 Wang (10.1016/j.canlet.2018.10.031_bib43) 2006; 71 Siegel (10.1016/j.canlet.2018.10.031_bib2) 2016; 66 Lunkes (10.1016/j.canlet.2018.10.031_bib4) 1998; 33 Fang (10.1016/j.canlet.2018.10.031_bib23) 2018; 90
References_xml	– volume: 12 year: 2017 ident: bib20 article-title: MicroRNA-200c inhibits epithelial-mesenchymal transition, invasion, and migration of lung cancer by targeting HMGB1 publication-title: PloS One – volume: 36 start-page: 877 year: 2017 end-page: 884 ident: bib25 article-title: Extracellular vesicles swarm the cancer microenvironment: from tumor-stroma communication to drug intervention publication-title: Oncogene – volume: 5 start-page: 455 year: 2016 end-page: 465 ident: bib7 article-title: Liquid biopsy based biomarkers in non-small cell lung cancer for diagnosis and treatment monitoring publication-title: Transl. Lung Cancer Res. – volume: 9 year: 2014 ident: bib27 article-title: Pigment epithelium-derived factor 34-mer peptide prevents liver fibrosis and hepatic stellate cell activation through down-regulation of the PDGF receptor publication-title: PloS One – volume: 293 start-page: 86 year: 2002 end-page: 92 ident: bib37 article-title: Adhesion of osteosarcoma cells to the 70-kDa core region of thrombospondin-1 is mediated by the alpha 4 beta 1 integrin publication-title: Biochem. Biophys. Res. Commun. – volume: 8 start-page: 82824 year: 2017 end-page: 82834 ident: bib31 article-title: miR-93-3p inhibition suppresses clear cell renal cell carcinoma proliferation, metastasis and invasion publication-title: Oncotarget – volume: 66 start-page: 7 year: 2016 end-page: 30 ident: bib2 article-title: Cancer statistics, 2016 publication-title: CA A Cancer J. Clin. – volume: 11 year: 2016 ident: bib17 article-title: Differential expression pattern of THBS1 and THBS2 in lung cancer: clinical outcome and a systematic-analysis of microarray databases publication-title: PloS One – volume: 13 start-page: 220 year: 2013 end-page: 221 ident: bib10 article-title: Genomic instability: DNA transitions publication-title: Nat. Rev. Canc. – volume: 30 start-page: 836 year: 2016 end-page: 848 ident: bib26 article-title: Extracellular vesicles in cancer: cell-to-cell mediators of metastasis publication-title: Cancer Cell – volume: 32 start-page: 1069 year: 2002 end-page: 1079 ident: bib42 article-title: T lymphocyte expression of thrombospondin-1 and adhesion to extracellular matrix components publication-title: Eur. J. Immunol. – volume: 7 start-page: 54852 year: 2016 end-page: 54866 ident: bib5 article-title: Lung cancer exosomes as drivers of epithelial mesenchymal transition publication-title: Oncotarget – volume: 36 start-page: 4929 year: 2017 end-page: 4942 ident: bib6 article-title: Hypoxic lung cancer-secreted exosomal miR-23a increased angiogenesis and vascular permeability by targeting prolyl hydroxylase and tight junction protein ZO-1 publication-title: Oncogene – volume: 64 start-page: 5632 year: 2004 end-page: 5642 ident: bib24 article-title: Inhibition of xenografted human melanoma growth and prevention of metastasis development by dual antiangiogenic/antitumor activities of pigment epithelium-derived factor publication-title: Cancer Res. – volume: 8 start-page: 84546 year: 2017 end-page: 84558 ident: bib40 article-title: Thrombospondin-1 is a multifaceted player in tumor progression publication-title: Oncotarget – volume: 33 start-page: 149 year: 1998 end-page: 163 ident: bib4 article-title: Pathological mechanisms in Huntington's disease and other polyglutamine expansion diseases publication-title: Essays Biochem. – volume: 125 start-page: 1045 year: 2009 end-page: 1053 ident: bib38 article-title: Estrogen regulation of thrombospondin-1 in human breast cancer cells publication-title: Int. J. Canc. – volume: 60 start-page: 387 year: 2006 end-page: 396 ident: bib8 article-title: PEDF: an endogenous factor displaying potent neuroprotective, neurotrophic, and antiangiogenic activity publication-title: Postepy Hig. Med. Dosw. – volume: 31 start-page: 114 year: 2004 end-page: 121 ident: bib35 article-title: Proteomic analysis of exosomes isolated from human malignant pleural effusions publication-title: Am. J. Respir. Cell Mol. Biol. – volume: 137 start-page: 1830 year: 2015 end-page: 1841 ident: bib18 article-title: Proteomic analysis of exosomes from nasopharyngeal carcinoma cell identifies intercellular transfer of angiogenic proteins publication-title: Int. J. Canc. – volume: 381 start-page: 49 year: 2016 end-page: 57 ident: bib1 article-title: A novel combinatorial strategy using Seliciclib((R)) and Belinostat((R)) for eradication of non-small cell lung cancer via apoptosis induction and BID activation publication-title: Cancer Lett. – volume: 8 start-page: 1319 year: 2017 ident: bib13 article-title: Pre-metastatic cancer exosomes induce immune surveillance by patrolling monocytes at the metastatic niche publication-title: Nat. Commun. – volume: 11 year: 2016 ident: bib22 article-title: Pigment epithelium-derived factor mediates autophagy and apoptosis in myocardial hypoxia/reoxygenation injury publication-title: PloS One – volume: 289 start-page: 30785 year: 2014 end-page: 30799 ident: bib33 article-title: Pigment epithelial-derived factor (PEDF)-triggered lung cancer cell apoptosis relies on p53 protein-driven Fas ligand (Fas-L) up-regulation and Fas protein cell surface translocation publication-title: J. Biol. Chem. – volume: 196 start-page: 77 year: 2003 end-page: 85 ident: bib9 article-title: Regulation of the expression of pigment epithelium-derived factor, an anti-angiogenic factor in human oral squamous cell carcinoma cell lines publication-title: Cancer Lett. – volume: 17 start-page: 507 year: 2016 end-page: 514 ident: bib12 article-title: Metformin inhibits prostate cancer cell proliferation, migration, and tumor growth through upregulation of PEDF expression publication-title: Cancer Biol. Ther. – volume: 71 start-page: 143 year: 2006 end-page: 151 ident: bib43 article-title: Enhanced proangiogenic signaling in thrombospondin-1-deficient retinal endothelial cells publication-title: Microvasc. Res. – volume: 313 start-page: C405 year: 2017 end-page: c420 ident: bib16 article-title: PEDF expression affects retinal endothelial cell proangiogenic properties through alterations in cell adhesive mechanisms publication-title: Am. J. Physiol. Cell Physiol. – volume: 28 start-page: R435 year: 2018 end-page: r444 ident: bib3 article-title: Exosomes and ectosomes in intercellular communication publication-title: Curr. Biol. – volume: 30 start-page: 127 year: 2004 end-page: 136 ident: bib36 article-title: Mechanisms of thrombospondin-1-mediated metastasis and angiogenesis publication-title: Semin. Thromb. Hemost. – volume: 8 start-page: 75968 year: 2017 end-page: 75978 ident: bib14 article-title: Exosomes containing differential expression of microRNA and mRNA in osteosarcoma that can predict response to chemotherapy publication-title: Oncotarget – volume: 3 year: 2015 ident: bib19 article-title: Expression of pigment epithelium-derived factor and thrombospondin-1 regulate proliferation and migration of retinal pigment epithelial cells publication-title: Phys. Rep. – volume: 105 start-page: 670 year: 2005 end-page: 678 ident: bib34 article-title: Extracellular phosphorylation converts pigment epithelium-derived factor from a neurotrophic to an antiangiogenic factor publication-title: Blood – volume: 154 start-page: 85 year: 2018 end-page: 94 ident: bib28 article-title: Simultaneous exposure of nematophagous fungi, entomopathogenic nematodes and entomopathogenic fungi can modulate belowground insect pest control publication-title: J. Invertebr. Pathol. – volume: 432 start-page: 28 year: 2018 end-page: 37 ident: bib15 article-title: Does metronomic chemotherapy induce tumor angiogenic dormancy? A review of available preclinical and clinical data publication-title: Cancer Lett. – volume: 274 start-page: 11408 year: 1999 end-page: 11416 ident: bib29 article-title: Pro-adhesive and chemotactic activities of thrombospondin-1 for breast carcinoma cells are mediated by alpha3beta1 integrin and regulated by insulin-like growth factor-1 and CD98 publication-title: J. Biol. Chem. – volume: 9 start-page: 19192 year: 2018 end-page: 19202 ident: bib32 article-title: Impact of pigment epithelium-derived factor on colorectal cancer in vitro and in vivo publication-title: Oncotarget – volume: 12 start-page: 5217 year: 2016 end-page: 5222 ident: bib11 article-title: Pigment epithelium-derived factor has a role in the progression of papillary thyroid carcinoma by affecting the HIF1alpha-VEGF signaling pathway publication-title: Oncol Lett – volume: 55 start-page: 611 year: 2009 end-page: 622 ident: bib21 article-title: The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments publication-title: Clin. Chem. – volume: 107 start-page: 10649 year: 2010 end-page: 10654 ident: bib39 article-title: B-Raf(V600E) and thrombospondin-1 promote thyroid cancer progression publication-title: Proc. Natl. Acad. Sci. U. S. A. – volume: 90 start-page: 2787 year: 2018 end-page: 2795 ident: bib23 article-title: Highly efficient exosome isolation and protein analysis by an integrated nanomaterial-based platform publication-title: Anal. Chem. – volume: 148 start-page: 61 year: 2014 end-page: 72 ident: bib30 article-title: Pigment epithelium-derived factor (PEDF) inhibits breast cancer metastasis by down-regulating fibronectin publication-title: Breast Canc. Res. Treat. – volume: 16 start-page: 483 year: 2016 ident: bib41 article-title: Osteopontin and thrombospondin-1 play opposite roles in promoting tumor aggressiveness of primary resected non-small cell lung cancer publication-title: BMC Canc. – volume: 9 year: 2014 ident: 10.1016/j.canlet.2018.10.031_bib27 article-title: Pigment epithelium-derived factor 34-mer peptide prevents liver fibrosis and hepatic stellate cell activation through down-regulation of the PDGF receptor publication-title: PloS One – volume: 71 start-page: 143 year: 2006 ident: 10.1016/j.canlet.2018.10.031_bib43 article-title: Enhanced proangiogenic signaling in thrombospondin-1-deficient retinal endothelial cells publication-title: Microvasc. Res. doi: 10.1016/j.mvr.2006.02.004 – volume: 8 start-page: 1319 year: 2017 ident: 10.1016/j.canlet.2018.10.031_bib13 article-title: Pre-metastatic cancer exosomes induce immune surveillance by patrolling monocytes at the metastatic niche publication-title: Nat. Commun. doi: 10.1038/s41467-017-01433-3 – volume: 125 start-page: 1045 year: 2009 ident: 10.1016/j.canlet.2018.10.031_bib38 article-title: Estrogen regulation of thrombospondin-1 in human breast cancer cells publication-title: Int. J. Canc. doi: 10.1002/ijc.24373 – volume: 13 start-page: 220 year: 2013 ident: 10.1016/j.canlet.2018.10.031_bib10 article-title: Genomic instability: DNA transitions publication-title: Nat. Rev. Canc. doi: 10.1038/nrc3490 – volume: 8 start-page: 82824 year: 2017 ident: 10.1016/j.canlet.2018.10.031_bib31 article-title: miR-93-3p inhibition suppresses clear cell renal cell carcinoma proliferation, metastasis and invasion publication-title: Oncotarget doi: 10.18632/oncotarget.20458 – volume: 8 start-page: 75968 year: 2017 ident: 10.1016/j.canlet.2018.10.031_bib14 article-title: Exosomes containing differential expression of microRNA and mRNA in osteosarcoma that can predict response to chemotherapy publication-title: Oncotarget doi: 10.18632/oncotarget.18373 – volume: 11 year: 2016 ident: 10.1016/j.canlet.2018.10.031_bib17 article-title: Differential expression pattern of THBS1 and THBS2 in lung cancer: clinical outcome and a systematic-analysis of microarray databases publication-title: PloS One doi: 10.1371/journal.pone.0161007 – volume: 8 start-page: 84546 year: 2017 ident: 10.1016/j.canlet.2018.10.031_bib40 article-title: Thrombospondin-1 is a multifaceted player in tumor progression publication-title: Oncotarget doi: 10.18632/oncotarget.19165 – volume: 289 start-page: 30785 year: 2014 ident: 10.1016/j.canlet.2018.10.031_bib33 article-title: Pigment epithelial-derived factor (PEDF)-triggered lung cancer cell apoptosis relies on p53 protein-driven Fas ligand (Fas-L) up-regulation and Fas protein cell surface translocation publication-title: J. Biol. Chem. doi: 10.1074/jbc.M114.590000 – volume: 64 start-page: 5632 year: 2004 ident: 10.1016/j.canlet.2018.10.031_bib24 article-title: Inhibition of xenografted human melanoma growth and prevention of metastasis development by dual antiangiogenic/antitumor activities of pigment epithelium-derived factor publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-04-0230 – volume: 11 year: 2016 ident: 10.1016/j.canlet.2018.10.031_bib22 article-title: Pigment epithelium-derived factor mediates autophagy and apoptosis in myocardial hypoxia/reoxygenation injury publication-title: PloS One doi: 10.1371/journal.pone.0156059 – volume: 36 start-page: 877 year: 2017 ident: 10.1016/j.canlet.2018.10.031_bib25 article-title: Extracellular vesicles swarm the cancer microenvironment: from tumor-stroma communication to drug intervention publication-title: Oncogene doi: 10.1038/onc.2016.253 – volume: 105 start-page: 670 year: 2005 ident: 10.1016/j.canlet.2018.10.031_bib34 article-title: Extracellular phosphorylation converts pigment epithelium-derived factor from a neurotrophic to an antiangiogenic factor publication-title: Blood doi: 10.1182/blood-2004-04-1569 – volume: 137 start-page: 1830 year: 2015 ident: 10.1016/j.canlet.2018.10.031_bib18 article-title: Proteomic analysis of exosomes from nasopharyngeal carcinoma cell identifies intercellular transfer of angiogenic proteins publication-title: Int. J. Canc. doi: 10.1002/ijc.29562 – volume: 36 start-page: 4929 year: 2017 ident: 10.1016/j.canlet.2018.10.031_bib6 article-title: Hypoxic lung cancer-secreted exosomal miR-23a increased angiogenesis and vascular permeability by targeting prolyl hydroxylase and tight junction protein ZO-1 publication-title: Oncogene doi: 10.1038/onc.2017.105 – volume: 293 start-page: 86 year: 2002 ident: 10.1016/j.canlet.2018.10.031_bib37 article-title: Adhesion of osteosarcoma cells to the 70-kDa core region of thrombospondin-1 is mediated by the alpha 4 beta 1 integrin publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/S0006-291X(02)00180-8 – volume: 66 start-page: 7 year: 2016 ident: 10.1016/j.canlet.2018.10.031_bib2 article-title: Cancer statistics, 2016 publication-title: CA A Cancer J. Clin. doi: 10.3322/caac.21332 – volume: 33 start-page: 149 year: 1998 ident: 10.1016/j.canlet.2018.10.031_bib4 article-title: Pathological mechanisms in Huntington's disease and other polyglutamine expansion diseases publication-title: Essays Biochem. doi: 10.1042/bse0330149 – volume: 432 start-page: 28 year: 2018 ident: 10.1016/j.canlet.2018.10.031_bib15 article-title: Does metronomic chemotherapy induce tumor angiogenic dormancy? A review of available preclinical and clinical data publication-title: Cancer Lett. doi: 10.1016/j.canlet.2018.06.002 – volume: 31 start-page: 114 year: 2004 ident: 10.1016/j.canlet.2018.10.031_bib35 article-title: Proteomic analysis of exosomes isolated from human malignant pleural effusions publication-title: Am. J. Respir. Cell Mol. Biol. doi: 10.1165/rcmb.2003-0238OC – volume: 107 start-page: 10649 year: 2010 ident: 10.1016/j.canlet.2018.10.031_bib39 article-title: B-Raf(V600E) and thrombospondin-1 promote thyroid cancer progression publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.1004934107 – volume: 12 start-page: 5217 year: 2016 ident: 10.1016/j.canlet.2018.10.031_bib11 article-title: Pigment epithelium-derived factor has a role in the progression of papillary thyroid carcinoma by affecting the HIF1alpha-VEGF signaling pathway publication-title: Oncol Lett doi: 10.3892/ol.2016.5316 – volume: 9 start-page: 19192 year: 2018 ident: 10.1016/j.canlet.2018.10.031_bib32 article-title: Impact of pigment epithelium-derived factor on colorectal cancer in vitro and in vivo publication-title: Oncotarget doi: 10.18632/oncotarget.24953 – volume: 381 start-page: 49 year: 2016 ident: 10.1016/j.canlet.2018.10.031_bib1 article-title: A novel combinatorial strategy using Seliciclib((R)) and Belinostat((R)) for eradication of non-small cell lung cancer via apoptosis induction and BID activation publication-title: Cancer Lett. doi: 10.1016/j.canlet.2016.07.023 – volume: 154 start-page: 85 year: 2018 ident: 10.1016/j.canlet.2018.10.031_bib28 article-title: Simultaneous exposure of nematophagous fungi, entomopathogenic nematodes and entomopathogenic fungi can modulate belowground insect pest control publication-title: J. Invertebr. Pathol. doi: 10.1016/j.jip.2018.04.004 – volume: 5 start-page: 455 year: 2016 ident: 10.1016/j.canlet.2018.10.031_bib7 article-title: Liquid biopsy based biomarkers in non-small cell lung cancer for diagnosis and treatment monitoring publication-title: Transl. Lung Cancer Res. doi: 10.21037/tlcr.2016.10.07 – volume: 196 start-page: 77 year: 2003 ident: 10.1016/j.canlet.2018.10.031_bib9 article-title: Regulation of the expression of pigment epithelium-derived factor, an anti-angiogenic factor in human oral squamous cell carcinoma cell lines publication-title: Cancer Lett. doi: 10.1016/S0304-3835(03)00185-X – volume: 30 start-page: 127 year: 2004 ident: 10.1016/j.canlet.2018.10.031_bib36 article-title: Mechanisms of thrombospondin-1-mediated metastasis and angiogenesis publication-title: Semin. Thromb. Hemost. doi: 10.1055/s-2004-822977 – volume: 60 start-page: 387 year: 2006 ident: 10.1016/j.canlet.2018.10.031_bib8 article-title: PEDF: an endogenous factor displaying potent neuroprotective, neurotrophic, and antiangiogenic activity publication-title: Postepy Hig. Med. Dosw. – volume: 148 start-page: 61 year: 2014 ident: 10.1016/j.canlet.2018.10.031_bib30 article-title: Pigment epithelium-derived factor (PEDF) inhibits breast cancer metastasis by down-regulating fibronectin publication-title: Breast Canc. Res. Treat. doi: 10.1007/s10549-014-3154-9 – volume: 16 start-page: 483 year: 2016 ident: 10.1016/j.canlet.2018.10.031_bib41 article-title: Osteopontin and thrombospondin-1 play opposite roles in promoting tumor aggressiveness of primary resected non-small cell lung cancer publication-title: BMC Canc. doi: 10.1186/s12885-016-2541-5 – volume: 17 start-page: 507 year: 2016 ident: 10.1016/j.canlet.2018.10.031_bib12 article-title: Metformin inhibits prostate cancer cell proliferation, migration, and tumor growth through upregulation of PEDF expression publication-title: Cancer Biol. Ther. doi: 10.1080/15384047.2016.1156273 – volume: 55 start-page: 611 year: 2009 ident: 10.1016/j.canlet.2018.10.031_bib21 article-title: The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments publication-title: Clin. Chem. doi: 10.1373/clinchem.2008.112797 – volume: 32 start-page: 1069 year: 2002 ident: 10.1016/j.canlet.2018.10.031_bib42 article-title: T lymphocyte expression of thrombospondin-1 and adhesion to extracellular matrix components publication-title: Eur. J. Immunol. doi: 10.1002/1521-4141(200204)32:4<1069::AID-IMMU1069>3.0.CO;2-E – volume: 7 start-page: 54852 year: 2016 ident: 10.1016/j.canlet.2018.10.031_bib5 article-title: Lung cancer exosomes as drivers of epithelial mesenchymal transition publication-title: Oncotarget doi: 10.18632/oncotarget.10243 – volume: 28 start-page: R435 year: 2018 ident: 10.1016/j.canlet.2018.10.031_bib3 article-title: Exosomes and ectosomes in intercellular communication publication-title: Curr. Biol. doi: 10.1016/j.cub.2018.01.059 – volume: 3 year: 2015 ident: 10.1016/j.canlet.2018.10.031_bib19 article-title: Expression of pigment epithelium-derived factor and thrombospondin-1 regulate proliferation and migration of retinal pigment epithelial cells publication-title: Phys. Rep. – volume: 12 year: 2017 ident: 10.1016/j.canlet.2018.10.031_bib20 article-title: MicroRNA-200c inhibits epithelial-mesenchymal transition, invasion, and migration of lung cancer by targeting HMGB1 publication-title: PloS One – volume: 313 start-page: C405 year: 2017 ident: 10.1016/j.canlet.2018.10.031_bib16 article-title: PEDF expression affects retinal endothelial cell proangiogenic properties through alterations in cell adhesive mechanisms publication-title: Am. J. Physiol. Cell Physiol. doi: 10.1152/ajpcell.00004.2017 – volume: 274 start-page: 11408 year: 1999 ident: 10.1016/j.canlet.2018.10.031_bib29 article-title: Pro-adhesive and chemotactic activities of thrombospondin-1 for breast carcinoma cells are mediated by alpha3beta1 integrin and regulated by insulin-like growth factor-1 and CD98 publication-title: J. Biol. Chem. doi: 10.1074/jbc.274.16.11408 – volume: 90 start-page: 2787 year: 2018 ident: 10.1016/j.canlet.2018.10.031_bib23 article-title: Highly efficient exosome isolation and protein analysis by an integrated nanomaterial-based platform publication-title: Anal. Chem. doi: 10.1021/acs.analchem.7b04861 – volume: 30 start-page: 836 year: 2016 ident: 10.1016/j.canlet.2018.10.031_bib26 article-title: Extracellular vesicles in cancer: cell-to-cell mediators of metastasis publication-title: Cancer Cell doi: 10.1016/j.ccell.2016.10.009
SSID	ssj0005475
Score	2.487795
Snippet	Exosomes are implicated in cancer cell development, migration and invasion. Pigment epithelium-derived factor (PEDF) is a secreted anticancer protein that can...
SourceID	proquest pubmed crossref elsevier
SourceType	Aggregation Database Index Database Enrichment Source Publisher
StartPage	287
SubjectTerms	Alpha-smooth muscle actin Angiogenesis Cell adhesion & migration Cell aggregation Cell migration Cytoskeletal remodeling Cytoskeleton Epithelium Exosome Exosomes Invasion Lung cancer Metastases Metastasis Microscopy Migration Motility Non-small cell lung cancer Non-small cell lung carcinoma NSCLC PEDF Pigment epithelium-derived factor Proteins Secretion THBS1 Thrombospondin Thrombospondin 1 Tumorigenicity Xenografts α-SMA
Title	Pigment epithelium-derived factor inhibits lung cancer migration and invasion by upregulating exosomal thrombospondin 1
URI	https://www.clinicalkey.com/#!/content/1-s2.0-S0304383518306463 https://dx.doi.org/10.1016/j.canlet.2018.10.031 https://www.ncbi.nlm.nih.gov/pubmed/30439539 https://www.proquest.com/docview/2160707017 https://www.proquest.com/docview/2135136100
Volume	442
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
link	http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1La9wwEB5CCqGXkjZ9bJoGBXpV1g_Jso8hNGwbEgJJITcjyVLqsmsv-0jaS397Zyx7aQ8hpfhkewSy5hvNjDUPgI_OW9QcVvIkd56LRHleJK7gIq88uSs6Synf-eIym3wVX27l7RacDrkwFFbZ7_1hT-926_7JuF_N8byux9d0qIf-lURQol7NqOKnEIpQfvzrjzAP0RXbJWJO1EP6XBfjhbPH1aEAr_yYYrzS-DH19Jj52amhs1140duP7CRM8SVsueYV7Fz0J-R78HBV39EPP-bmlG0xrdczXiHK7l3FQm8dVjffalOvlmyKgs4ssX3BZvVdwALTTYUk95p-ozHzk63ni9CvHpUccz_aZTvDCVB7hZlpKcAWtR-LX8PN2aeb0wnvmytwK6Vc8djmNpFUeiVNXaKlVcYWeWJzaaPMKKErdBZ17L2OXOEjIy25WgYtNK-8Vekb2G7axr0DpoWOYmezSKFtpdH_sEWGkm5EHHuJBvwI0mFJS9sXHqf-F9NyiDD7XgZGlMQIeoqMGAHfjJqHwhtP0MuBW-WQVIrbYIma4YlxajPuL-D9w8iDARRlL_jLMqGCfXjFagRHm9cosnQOoxvXrokGQYsLH0UjeBvAtPlEwnQh02L_v6f1Hp7jXREiyw9ge7VYuw9oOK3MYScZh_Ds5PP55PI324gYTQ
linkProvider	Elsevier
linkToHtml	http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnR3ZbhMxcFRSCXhB3AQKGIlXk728x2NVUaW0iZAIUt8s22uXRclulKPA3zMTe4N4qIrQvnk9kj2HZ8aeA-C9dQY1hxE8Ka3jWVI4XiW24llZO3JXVJ5SvvNkmo-_Zp8uxeUBnPS5MBRWGc5-f6bvTuswMgrYHC2bZvSFHvXQvxLIlKhX8_QOHFJ1KjGAw-Oz8_H0T6RHtqu3S_M5AfQZdLswL9wAIohivMoPFOaVxjdpqJss0J0mOn0ID4IJyY79Kh_BgW0fw91JeCR_Aj8-N1d058fskhIu5s12wWtktGtbM99ehzXtt0Y3mzWbo6wzQ5RfsUVz5dmBqbbGKdeKbtKY_sW2y5VvWY96jtmf3bpb4AKow8JCdxRjiwqQxU9hdvpxdjLmob8CN0KIDY9NaRJB1VfS1CZKmEKbqkxMKUyU6yJTNfqLKnZORbZykRaGvC2NRpornCnSZzBou9a-AKYyFcXW5FGB5pVCF8RUOQq7zuLYCbThh5D2KJUm1B6nFhhz2QeZfZeeEJIIQaNIiCHwPdTS1964Zb7oqSX7vFI8CSUqh1vgij3cX7z3D5BHPVPIIPtrmVDNPvziYgjv9r9RaukpRrW229Ic5FtEfBQN4blnpv0Wia0rkVYv_3tZb-HeeDa5kBdn0_NXcB__VD7Q_AgGm9XWvkY7aqPfBDn5DWSqGv4
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Pigment+epithelium-derived+factor+inhibits+lung+cancer+migration+and+invasion+by+upregulating+exosomal+thrombospondin+1&rft.jtitle=Cancer+letters&rft.au=Huang%2C+Wen-Tsung&rft.au=Chong%2C+Inn-Wen&rft.au=Chen%2C+Hsiu-Lin&rft.au=Li%2C+Chia-Yang&rft.date=2019-02-01&rft.pub=Elsevier+B.V&rft.issn=0304-3835&rft.eissn=1872-7980&rft.volume=442&rft.spage=287&rft.epage=298&rft_id=info:doi/10.1016%2Fj.canlet.2018.10.031&rft.externalDocID=S0304383518306463
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0304-3835&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0304-3835&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0304-3835&client=summon