Enhancer of zeste homolog 2 epigenetically silences multiple tumor suppressor microRNAs to promote liver cancer metastasis

• Published in: Hepatology (Baltimore, Md.) Vol. 56; no. 2; pp. 622 - 631
• Main Authors: Au, Sandy Leung-Kuen, Wong, Carmen Chak-Lui, Lee, Joyce Man-Fong, Fan, Dorothy Ngo-Yin, Tsang, Felice Hoching, Ng, Irene Oi-Lin, Wong, Chun-Ming
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.08.2012; Wiley; Wolters Kluwer Health, Inc
• Subjects: Animals; Biological and medical sciences; Carcinoma, Hepatocellular - genetics; Carcinoma, Hepatocellular - secondary; Cell Movement - physiology; Computer Simulation; DNA-Binding Proteins - genetics; Enhancer of Zeste Homolog 2 Protein; Epigenesis, Genetic - genetics; Epigenetics; Gastroenterology. Liver. Pancreas. Abdomen; Gene expression; Gene Knockdown Techniques; Gene Silencing - physiology; Hep G2 Cells; Hepatology; Humans; Liver cancer; Liver Neoplasms - genetics; Liver Neoplasms - pathology; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Male; Medical sciences; Metastasis; Mice; Mice, Inbred BALB C; Mice, Nude; MicroRNAs - genetics; Motility; Neoplasm Transplantation; Polycomb Repressive Complex 2; Polycomb-Group Proteins; Repressor Proteins - genetics; Transcription Factors - genetics; Transplantation, Heterologous; Tumors; Liver cancer; Silence; Multiple; Gastroenterology; Digestive diseases; Hepatic disease; Suppressor; Malignant tumor; Liver metastasis; Cancer

Epigenetic alterations and microRNA (miRNA) deregulation are common in hepatocellular carcinoma (HCC). The histone H3 lysine 27 (H3K27) tri‐methylating enzyme, enhancer of zeste homolog 2 (EZH2) mediates epigenetic silencing of gene expression and is frequently up‐regulated in human cancers. In this...