Kinetic brain analysis and whole-body imaging in monkey of [11C]MNPA: A dopamine agonist radioligand

• Published in: Synapse (New York, N.Y.) Vol. 62; no. 9; pp. 700 - 709
• Main Authors: Seneca, Nicholas, Skinbjerg, Mette, Zoghbi, Sami S., Liow, Jeih-San, Gladding, Robert L., Hong, Jinsoo, Kannan, Pavitra, Tuan, Edward, Sibley, David R., Halldin, Christer, Pike, Victor W., Innis, Robert B.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.09.2008
• Subjects: [11C]MNPA; Animals; Brain - diagnostic imaging; Brain - metabolism; Carbon Radioisotopes - blood; Carbon Radioisotopes - pharmacokinetics; DA D2/3 receptor agonist radioligand; dosimetry; kinetic analysis; Macaca mulatta; Magnetic Resonance Imaging; Male; Naproxen - blood; Naproxen - pharmacokinetics; PET; Positron-Emission Tomography - methods; Radiometry; Receptors, Dopamine D2 - metabolism; Receptors, Dopamine D3 - metabolism; Tissue Distribution; Whole Body Imaging; whole-body biodistribution

With a view to future extension of the use of the agonist radioligand [11C]MNPA ([O‐methyl‐11C]2‐methoxy‐N‐propylnorapomorphine) from animals to humans, we performed two positron emission tomography (PET) studies in monkeys. First, we assessed the ability to quantify the brain uptake of [11C]MNPA wi...