Systemic Immune Activation and HIV Shedding in the Female Genital Tract

• Published in: Journal of acquired immune deficiency syndromes (1999) Vol. 71; no. 2; p. 155
• Main Authors: Spencer, LaShonda Y, Christiansen, Shawna, Wang, Chia-Hao H, Mack, Wendy J, Young, Mary, Strickler, Howard D, Anastos, Kathryn, Minkoff, Howard, Cohen, Mardge, Geenblatt, Ruth M, Karim, Roksana, Operskalski, Eva, Frederick, Toni, Homans, James D, Landay, Alan, Kovacs, Andrea
• Format: Journal Article
• Language: English
• Published: United States 01.02.2016
• Subjects: Adult; CD8-Positive T-Lymphocytes - immunology; Female; Genitalia, Female - immunology; Genitalia, Female - virology; HIV Infections - immunology; HIV Infections - virology; HIV-1 - genetics; HIV-1 - isolation & purification; Humans; Lymphocyte Activation; RNA, Viral - blood; RNA, Viral - genetics; Sexually Transmitted Diseases - immunology; Sexually Transmitted Diseases - microbiology; Virus Shedding
• ISSN: 1944-7884
• DOI: 10.1097/QAI.0000000000000823

Plasma HIV RNA is the most significant determinant of cervical HIV shedding. However, shedding is also associated with sexually transmitted infections (STIs) and cervical inflammation. The mechanism by which this occurs is poorly understood. There is evidence that systemic immune activation promotes...