A Double-blind, Randomized, Placebo-controlled Study of the Efficacy and Safety of Duloxetine for the Treatment of Chronic Pain Due to Osteoarthritis of the Knee

• Published in: Pain practice Vol. 11; no. 1; pp. 33 - 41
• Main Authors: Chappell, Amy S., Desaiah, Durisala, Liu-Seifert, Hong, Zhang, Shuyu, Skljarevski, Vladimir, Belenkov, Yuri, Brown, Jacques P.
• Format: Journal Article
• Language: English
• Published: Malden, USA Blackwell Publishing Inc 01.01.2011
• Subjects: acute phase therapy; Aged; Analgesics - therapeutic use; Chronic Disease; chronic pain; Clinical trials; Constipation; Double-Blind Method; Duloxetine; Duloxetine Hydrochloride; Female; Humans; Inventories; Knee; Male; Middle Aged; Nausea; Osteoarthritis; osteoarthritis of the knee; Osteoarthritis, Knee - complications; Osteoarthritis, Knee - drug therapy; Pain; Pain - drug therapy; Pain - etiology; Pain Measurement; Physical training; Severity of Illness Index; Thiophenes - therapeutic use; Time Factors; Treatment Outcome

Objective:  To evaluate the efficacy and safety of duloxetine in the treatment of chronic pain due to osteoarthritis of the knee. Methods:  This was a 13‐week, randomized, double‐blind, placebo‐controlled trial in patients meeting American College of Rheumatology clinical and radiographic criteria f...