Positional Stability and Membrane Occupancy Define Skin Fibroblast Homeostasis In Vivo

• Published in: Cell Vol. 175; no. 6; pp. 1620 - 1633.e13
• Main Authors: Marsh, Edward, Gonzalez, David G., Lathrop, Elizabeth A., Boucher, Jonathan, Greco, Valentina
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 29.11.2018
• Subjects: aging; Animals; cell behaviors; Cell Membrane - genetics; Cell Membrane - metabolism; Cell Nucleus - genetics; Cell Nucleus - metabolism; Cells, Cultured; fibroblasts; Fibroblasts - cytology; Fibroblasts - metabolism; homeostasis; Homeostasis - physiology; intravital imaging; longevity; mesenchyme; Mice; Mice, Transgenic; Skin - cytology; Skin - metabolism; skin homeostasis; fibroblasts; mesenchyme; cell behaviors; skin homeostasis; aging; intravital imaging

Fibroblasts are an essential cellular and structural component of our organs. Despite several advances, the critical behaviors that fibroblasts utilize to maintain their homeostasis in vivo have remained unclear. Here, by tracking the same skin fibroblasts in live mice, we show that fibroblast posit...