TBK1 at the Crossroads of Inflammation and Energy Homeostasis in Adipose Tissue

• Published in: Cell Vol. 172; no. 4; pp. 731 - 743.e12
• Main Authors: Zhao, Peng, Wong, Kai in, Sun, Xiaoli, Reilly, Shannon M., Uhm, Maeran, Liao, Zhongji, Skorobogatko, Yuliya, Saltiel, Alan R.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 08.02.2018
• Subjects: adipocytes; Adipocytes - metabolism; Adipocytes - pathology; adipose tissue; Adipose Tissue - metabolism; Adipose Tissue - pathology; AMP-Activated Protein Kinases - genetics; AMP-Activated Protein Kinases - metabolism; AMPK; Animals; Autophagy-Related Protein-1 Homolog - genetics; Autophagy-Related Protein-1 Homolog - metabolism; Cell Line, Transformed; cytokine; cytokines; Dietary Fats - adverse effects; Dietary Fats - pharmacology; energy expenditure; Energy Metabolism; enzymes; homeostasis; inflammation; Inflammation - chemically induced; Inflammation - genetics; Inflammation - metabolism; Inflammation - pathology; insulin resistance; malnutrition; Mice; Mice, Knockout; mitochondria; NF-kappa B - genetics; NF-kappa B - metabolism; NF-kappaB-Inducing Kinase; NFκB; obesity; Oxygen Consumption - drug effects; phosphorylation; Phosphorylation - drug effects; Phosphorylation - genetics; protein phosphorylation; Protein Serine-Threonine Kinases - genetics; Protein Serine-Threonine Kinases - metabolism; Signal Transduction; transcription factor NF-kappa B; cytokine; NFκB; mitochondria; AMPK; protein phosphorylation; energy expenditure; insulin resistance; obesity

The noncanonical IKK family member TANK-binding kinase 1 (TBK1) is activated by pro-inflammatory cytokines, but its role in controlling metabolism remains unclear. Here, we report that the kinase uniquely controls energy metabolism. Tbk1 expression is increased in adipocytes of HFD-fed mice. Adipocy...