TBK1 at the Crossroads of Inflammation and Energy Homeostasis in Adipose Tissue

The noncanonical IKK family member TANK-binding kinase 1 (TBK1) is activated by pro-inflammatory cytokines, but its role in controlling metabolism remains unclear. Here, we report that the kinase uniquely controls energy metabolism. Tbk1 expression is increased in adipocytes of HFD-fed mice. Adipocy...

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Published in	Cell Vol. 172; no. 4; pp. 731 - 743.e12
Main Authors	Zhao, Peng, Wong, Kai in, Sun, Xiaoli, Reilly, Shannon M., Uhm, Maeran, Liao, Zhongji, Skorobogatko, Yuliya, Saltiel, Alan R.
Format	Journal Article
Language	English
Published	United States Elsevier Inc 08.02.2018
Subjects	adipocytes Adipocytes - metabolism Adipocytes - pathology adipose tissue Adipose Tissue - metabolism Adipose Tissue - pathology AMP-Activated Protein Kinases - genetics AMP-Activated Protein Kinases - metabolism AMPK Animals Autophagy-Related Protein-1 Homolog - genetics Autophagy-Related Protein-1 Homolog - metabolism Cell Line, Transformed cytokine cytokines Dietary Fats - adverse effects Dietary Fats - pharmacology energy expenditure Energy Metabolism enzymes homeostasis inflammation Inflammation - chemically induced Inflammation - genetics Inflammation - metabolism Inflammation - pathology insulin resistance malnutrition Mice Mice, Knockout mitochondria NF-kappa B - genetics NF-kappa B - metabolism NF-kappaB-Inducing Kinase NFκB obesity Oxygen Consumption - drug effects phosphorylation Phosphorylation - drug effects Phosphorylation - genetics protein phosphorylation Protein Serine-Threonine Kinases - genetics Protein Serine-Threonine Kinases - metabolism Signal Transduction transcription factor NF-kappa B cytokine NFκB mitochondria AMPK protein phosphorylation energy expenditure insulin resistance obesity
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Abstract	The noncanonical IKK family member TANK-binding kinase 1 (TBK1) is activated by pro-inflammatory cytokines, but its role in controlling metabolism remains unclear. Here, we report that the kinase uniquely controls energy metabolism. Tbk1 expression is increased in adipocytes of HFD-fed mice. Adipocyte-specific TBK1 knockout (ATKO) attenuates HFD-induced obesity by increasing energy expenditure; further studies show that TBK1 directly inhibits AMPK to repress respiration and increase energy storage. Conversely, activation of AMPK under catabolic conditions can increase TBK1 activity through phosphorylation, mediated by AMPK’s downstream target ULK1. Surprisingly, ATKO also exaggerates adipose tissue inflammation and insulin resistance. TBK1 suppresses inflammation by phosphorylating and inducing the degradation of the IKK kinase NIK, thus attenuating NF-κB activity. Moreover, TBK1 mediates the negative impact of AMPK activity on NF-κB activation. These data implicate a unique role for TBK1 in mediating bidirectional crosstalk between energy sensing and inflammatory signaling pathways in both over- and undernutrition. [Display omitted] •TBK1 operates at the intersection of energy expenditure and inflammation•TBK1 deficiency attenuates HFD-induced obesity but exaggerates inflammation•TBK1 represses energy expenditure by phosphorylating and inhibiting AMPK•TBK1 attenuates NF-κB activation and mediates the anti-inflammatory effect of AMPK Adipose tissue inflammation plays an important role in reducing energy expenditure in obesity.
AbstractList	The noncanonical IKK family member TANK-binding kinase 1 (TBK1) is activated by pro-inflammatory cytokines, but its role in controlling metabolism remains unclear. Here, we report that the kinase uniquely controls energy metabolism. Tbk1 expression is increased in adipocytes of HFD-fed mice. Adipocyte-specific TBK1 knockout (ATKO) attenuates HFD-induced obesity by increasing energy expenditure; further studies show that TBK1 directly inhibits AMPK to repress respiration and increase energy storage. Conversely, activation of AMPK under catabolic conditions can increase TBK1 activity through phosphorylation, mediated by AMPK’s downstream target ULK1. Surprisingly, ATKO also exaggerates adipose tissue inflammation and insulin resistance. TBK1 suppresses inflammation by phosphorylating and inducing the degradation of the IKK kinase NIK, thus attenuating NF-κB activity. Moreover, TBK1 mediates the negative impact of AMPK activity on NF-κB activation. These data implicate a unique role for TBK1 in mediating bidirectional crosstalk between energy sensing and inflammatory signaling pathways in both over- and undernutrition. [Display omitted] •TBK1 operates at the intersection of energy expenditure and inflammation•TBK1 deficiency attenuates HFD-induced obesity but exaggerates inflammation•TBK1 represses energy expenditure by phosphorylating and inhibiting AMPK•TBK1 attenuates NF-κB activation and mediates the anti-inflammatory effect of AMPK Adipose tissue inflammation plays an important role in reducing energy expenditure in obesity. The noncanonical IKK family member TANK-binding kinase 1 (TBK1) is activated by pro-inflammatory cytokines, but its role in controlling metabolism remains unclear. Here, we report that the kinase uniquely controls energy metabolism. Tbk1 expression is increased in adipocytes of HFD-fed mice. Adipocyte-specific TBK1 knockout (ATKO) attenuates HFD-induced obesity by increasing energy expenditure; further studies show that TBK1 directly inhibits AMPK to repress respiration and increase energy storage. Conversely, activation of AMPK under catabolic conditions can increase TBK1 activity through phosphorylation, mediated by AMPK’s downstream target ULK1. Surprisingly, ATKO also exaggerates adipose tissue inflammation and insulin resistance. TBK1 suppresses inflammation by phosphorylating and inducing the degradation of the IKK kinase NIK, thus attenuating NF-κB activity. Moreover, TBK1 mediates the negative impact of AMPK activity on NF-κB activation. These data implicate a unique role for TBK1 in mediating bidirectional crosstalk between energy sensing and inflammatory signaling pathways in both over- and undernutrition. The noncanonical IKK family member TANK-binding kinase 1 (TBK1) is activated by pro-inflammatory cytokines, but its role in controlling metabolism remains unclear. Here, we report that the kinase uniquely controls energy metabolism. Tbk1 expression is increased in adipocytes of HFD-fed mice. Adipocyte-specific TBK1 knockout (ATKO) attenuates HFD-induced obesity by increasing energy expenditure; further studies show that TBK1 directly inhibits AMPK to repress respiration and increase energy storage. Conversely, activation of AMPK under catabolic conditions can increase TBK1 activity through phosphorylation, mediated by AMPK's downstream target ULK1. Surprisingly, ATKO also exaggerates adipose tissue inflammation and insulin resistance. TBK1 suppresses inflammation by phosphorylating and inducing the degradation of the IKK kinase NIK, thus attenuating NF-κB activity. Moreover, TBK1 mediates the negative impact of AMPK activity on NF-κB activation. These data implicate a unique role for TBK1 in mediating bidirectional crosstalk between energy sensing and inflammatory signaling pathways in both over- and undernutrition.The noncanonical IKK family member TANK-binding kinase 1 (TBK1) is activated by pro-inflammatory cytokines, but its role in controlling metabolism remains unclear. Here, we report that the kinase uniquely controls energy metabolism. Tbk1 expression is increased in adipocytes of HFD-fed mice. Adipocyte-specific TBK1 knockout (ATKO) attenuates HFD-induced obesity by increasing energy expenditure; further studies show that TBK1 directly inhibits AMPK to repress respiration and increase energy storage. Conversely, activation of AMPK under catabolic conditions can increase TBK1 activity through phosphorylation, mediated by AMPK's downstream target ULK1. Surprisingly, ATKO also exaggerates adipose tissue inflammation and insulin resistance. TBK1 suppresses inflammation by phosphorylating and inducing the degradation of the IKK kinase NIK, thus attenuating NF-κB activity. Moreover, TBK1 mediates the negative impact of AMPK activity on NF-κB activation. These data implicate a unique role for TBK1 in mediating bidirectional crosstalk between energy sensing and inflammatory signaling pathways in both over- and undernutrition. The noncanonical IKK family member TANK-binding kinase 1 (TBK1) is activated by pro-inflammatory cytokines, but its role in controlling metabolism remains unclear. Here we report that the kinase uniquely controls energy metabolism. Tbk1 expression is increased in adipocytes of HFD-fed mice. Adipocyte-specific TBK1 knockout (ATKO) attenuates HFD-induced obesity by increasing energy expenditure; further studies show that TBK1 directly inhibits AMPK to repress respiration and increase energy storage. Conversely, activation of AMPK under catabolic conditions can increase TBK1 activity through phosphorylation, mediated by AMPK’s downstream target ULK1. Surprisingly, ATKO also exaggerates adipose tissue inflammation and insulin resistance. TBK1 suppresses inflammation by phosphorylating and inducing the degradation of the IKK kinase NIK, thus attenuating NFκB activity. Moreover, TBK1 mediates the negative impact of AMPK activity on NFκB activation. These data implicate a unique role for TBK1 in mediating bi-directional crosstalk between energy sensing and inflammatory signaling pathways in both over- and under-nutrition. Adipose tissue inflammation plays an important role in reducing energy expenditure in obesity The noncanonical IKK family member TANK-binding kinase 1 (TBK1) is activated by pro-inflammatory cytokines, but its role in controlling metabolism remains unclear. Here, we report that the kinase uniquely controls energy metabolism. Tbk1 expression is increased in adipocytes of HFD-fed mice. Adipocyte-specific TBK1 knockout (ATKO) attenuates HFD-induced obesity by increasing energy expenditure; further studies show that TBK1 directly inhibits AMPK to repress respiration and increase energy storage. Conversely, activation of AMPK under catabolic conditions can increase TBK1 activity through phosphorylation, mediated by AMPK's downstream target ULK1. Surprisingly, ATKO also exaggerates adipose tissue inflammation and insulin resistance. TBK1 suppresses inflammation by phosphorylating and inducing the degradation of the IKK kinase NIK, thus attenuating NF-κB activity. Moreover, TBK1 mediates the negative impact of AMPK activity on NF-κB activation. These data implicate a unique role for TBK1 in mediating bidirectional crosstalk between energy sensing and inflammatory signaling pathways in both over- and undernutrition.
Author	Skorobogatko, Yuliya Uhm, Maeran Sun, Xiaoli Saltiel, Alan R. Liao, Zhongji Wong, Kai in Zhao, Peng Reilly, Shannon M.
AuthorAffiliation	1 Division of Metabolism and Endocrinology, Department of Medicine. University of California-San Diego, La Jolla, CA 92093, USA 2 Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA
AuthorAffiliation_xml	– name: 1 Division of Metabolism and Endocrinology, Department of Medicine. University of California-San Diego, La Jolla, CA 92093, USA – name: 2 Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA
Author_xml	– sequence: 1 givenname: Peng surname: Zhao fullname: Zhao, Peng organization: Division of Metabolism and Endocrinology, Department of Medicine, University of California–San Diego, La Jolla, CA 92093, USA – sequence: 2 givenname: Kai in surname: Wong fullname: Wong, Kai in organization: Division of Metabolism and Endocrinology, Department of Medicine, University of California–San Diego, La Jolla, CA 92093, USA – sequence: 3 givenname: Xiaoli surname: Sun fullname: Sun, Xiaoli organization: Division of Metabolism and Endocrinology, Department of Medicine, University of California–San Diego, La Jolla, CA 92093, USA – sequence: 4 givenname: Shannon M. surname: Reilly fullname: Reilly, Shannon M. organization: Division of Metabolism and Endocrinology, Department of Medicine, University of California–San Diego, La Jolla, CA 92093, USA – sequence: 5 givenname: Maeran surname: Uhm fullname: Uhm, Maeran organization: Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA – sequence: 6 givenname: Zhongji surname: Liao fullname: Liao, Zhongji organization: Division of Metabolism and Endocrinology, Department of Medicine, University of California–San Diego, La Jolla, CA 92093, USA – sequence: 7 givenname: Yuliya surname: Skorobogatko fullname: Skorobogatko, Yuliya organization: Division of Metabolism and Endocrinology, Department of Medicine, University of California–San Diego, La Jolla, CA 92093, USA – sequence: 8 givenname: Alan R. surname: Saltiel fullname: Saltiel, Alan R. email: asaltiel@ucsd.edu organization: Division of Metabolism and Endocrinology, Department of Medicine, University of California–San Diego, La Jolla, CA 92093, USA
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/29425491$$D View this record in MEDLINE/PubMed
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Cites_doi	10.1016/j.molcel.2013.03.022 10.4161/adip.29674 10.1038/sj.ijo.0800640 10.1038/cr.2010.177 10.1172/JCI200319451 10.1016/S0092-8674(00)81410-5 10.1172/JCI200319246 10.1194/jlr.P022905 10.1056/NEJM199503093321001 10.1038/nature11862 10.1172/JCI26498 10.1073/pnas.91.11.4854 10.1038/ncb2152 10.1038/nrendo.2017.90 10.1017/S0007114515000100 10.1016/S0092-8674(00)80611-X 10.1038/ncomms8965 10.1038/srep17977 10.1038/nrm3311 10.1093/ajcn/85.4.1014 10.1038/nm.3082 10.1172/JCI117936 10.1016/j.molmet.2013.04.003 10.1101/gad.17420111 10.1038/ncb2329 10.1074/jbc.M601284200 10.1113/jphysiol.2006.109512 10.1016/j.cmet.2010.12.008 10.1016/j.cmet.2016.06.006 10.1007/BF00429772 10.1038/ncb2757 10.1073/pnas.0308061100 10.1097/MOL.0b013e328328d0a4 10.1038/nrm2391 10.1038/cr.2008.273 10.7554/eLife.01119 10.1038/ni.2423 10.1101/cshperspect.a001651 10.1038/oby.2007.354 10.1016/j.cell.2015.09.035 10.1089/dna.2014.2630 10.1042/BJ20131344 10.1113/jphysiol.2006.111484 10.1016/j.bbrc.2010.11.127 10.1074/jbc.M512831200 10.1056/NEJM198802253180802 10.1038/cddis.2014.70 10.2337/dc05-2565 10.1016/j.cmet.2017.08.009 10.1126/science.7678183 10.3945/ajcn.112.036350 10.1002/oby.20605 10.1007/s00109-011-0748-0 10.1073/pnas.1119296109 10.1016/j.molcel.2008.03.003 10.1126/science.271.5249.665 10.1172/JCI57132 10.1016/j.cell.2009.06.046 10.1126/science.1073160 10.1016/j.cmet.2017.06.006 10.1073/pnas.1121552109 10.1084/jem.20040528 10.1073/pnas.0707959105 10.1038/nm1185 10.1161/CIRCULATIONAHA.111.087213 10.3109/10409238.2010.488215 10.4049/jimmunol.165.8.4704
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Keywords	cytokine NFκB mitochondria AMPK protein phosphorylation energy expenditure insulin resistance obesity
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References	Hotamisligil, Murray, Choy, Spiegelman (bib23) 1994; 91 Huang, Lin, Chen, Lin, Cheng, Kao (bib26) 2015; 34 Delhase, Kim, Lee, Naiki-Ito, Chen, Ahn, Murata, Kim, Lautsch, Kobayashi (bib12) 2012; 109 Puigserver, Wu, Park, Graves, Wright, Spiegelman (bib49) 1998; 92 Jeffery, Berry, Church, Yu, Shook, Horsley, Rosen, Rodeheffer (bib27) 2014; 3 Kanda, Tateya, Tamori, Kotani, Hiasa, Kitazawa, Kitazawa, Miyachi, Maeda, Egashira, Kasuga (bib30) 2006; 116 Lohman, Leskov, Butcher, Johnstone, Stokes, Begandt, DeLalio, Best, Penuela, Leitinger (bib37) 2015; 6 Cauwels, Rogge, Vandendriessche, Shiva, Brouckaert (bib6) 2014; 5 Kamei, Tobe, Suzuki, Ohsugi, Watanabe, Kubota, Ohtsuka-Kowatari, Kumagai, Sakamoto, Kobayashi (bib29) 2006; 281 Russell, Tian, Yuan, Park, Chang, Kim, Kim, Neufeld, Dillin, Guan (bib56) 2013; 15 Coleman (bib10) 1978; 14 Roberts, Leibel (bib55) 1998; 22 Reznick, Shulman (bib54) 2006; 574 Schnurr, Then, Galambos, Scholz, Siegmund, Endres, Eigler (bib58) 2000; 165 Chiang, Bazuine, Lumeng, Geletka, Mowers, White, Ma, Zhou, Qi, Westcott (bib7) 2009; 138 Garcia-Haro, Garcia-Gimeno, Neumann, Beullens, Bollen, Sanz (bib13) 2010; 24 Leibel, Rosenbaum, Hirsch (bib36) 1995; 332 Hotamisligil, Shargill, Spiegelman (bib22) 1993; 259 Larson-Meyer, Heilbronn, Redman, Newcomer, Frisard, Anton, Smith, Alfonso, Ravussin (bib34) 2006; 29 Martin, Alquier, Asakura, Furukawa, Preitner, Kahn (bib40) 2006; 281 Jin, Xiao, Chang, Yu, Hu, Starr, Brittain, Chang, Cheng, Sun (bib28) 2012; 13 Kazak, Chouchani, Lu, Jedrychowski, Bare, Mina, Kumari, Zhang, Vuckovic, Laznik-Bogoslavski (bib32) 2017; 26 Baker, Hayden, Ghosh (bib3) 2011; 13 Reilly, Saltiel (bib52) 2017; 13 Choi, Kim, Kwon, Ryoo, Kim, Jung (bib8) 2015; 113 Wan, Root-McCaig, Castellani, Kemp, Steinberg, Wright (bib63) 2014; 22 Salminen, Hyttinen, Kaarniranta (bib57) 2011; 89 Rasmussen, Larsen, Mortensen, Due, Astrup (bib50) 2007; 85 Hardie, Ross, Hawley (bib19) 2012; 13 Kim, Kundu, Viollet, Guan (bib33) 2011; 13 Gwinn, Shackelford, Egan, Mihaylova, Mery, Vasquez, Turk, Shaw (bib16) 2008; 30 Mowers, Uhm, Reilly, Simon, Leto, Chiang, Chang, Saltiel (bib44) 2013; 2 Hill, Wyatt, Peters (bib21) 2012; 126 Hotamisligil, Arner, Caro, Atkinson, Spiegelman (bib24) 1995; 95 Reilly, Chiang, Decker, Chang, Uhm, Larsen, Rubin, Mowers, White, Hochberg (bib53) 2013; 19 Hotamisligil, Peraldi, Budavari, Ellis, White, Spiegelman (bib25) 1996; 271 Lumeng, Saltiel (bib38) 2011; 121 Xu, Gauthier, Hess, Apovian, Cacicedo, Gokce, Farb, Valentine, Ruderman (bib67) 2012; 53 Bachman, Dhillon, Zhang, Cinti, Bianco, Kobilka, Lowell (bib2) 2002; 297 Lawrence (bib35) 2009; 1 Mihaylova, Shaw (bib42) 2011; 13 Hawley, Ross, Gowans, Tibarewal, Leslie, Hardie (bib20) 2014; 459 Zarnegar, Yamazaki, He, Cheng (bib68) 2008; 105 Martin, Heilbronn, de Jonge, DeLany, Volaufova, Anton, Redman, Smith, Ravussin (bib41) 2007; 15 Suzuki, Bridges, Nakada, Skiniotis, Morrison, Lin, Saltiel, Inoki (bib61) 2013; 50 Hall, Heymsfield, Kemnitz, Klein, Schoeller, Speakman (bib17) 2012; 95 Kazak, Chouchani, Jedrychowski, Erickson, Shinoda, Cohen, Vetrivelan, Lu, Laznik-Bogoslavski, Hasenfuss (bib31) 2015; 163 Shaw, Kosmatka, Bardeesy, Hurley, Witters, DePinho, Cantley (bib59) 2004; 101 Oral, Reilly, Gomez, Meral, Butz, Ajluni, Chenevert, Korytnaya, Neidert, Hench (bib46) 2017; 26 Zhao, Stephens (bib69) 2013; 2 Pazos, Lima, Tovar, González-Touceda, Diéguez, García (bib47) 2015; 5 Cantó, Auwerx (bib4) 2009; 20 Sun (bib60) 2011; 21 Daval, Foufelle, Ferré (bib11) 2006; 574 Guilherme, Virbasius, Puri, Czech (bib15) 2008; 9 Mottillo, Desjardins, Crane, Smith, Green, Ducommun, Henriksen, Rebalka, Razi, Sakamoto (bib43) 2016; 24 Viollet, Horman, Leclerc, Lantier, Foretz, Billaud, Giri, Andreelli (bib62) 2010; 45 Wu, Puigserver, Andersson, Zhang, Adelmant, Mootha, Troy, Cinti, Lowell, Scarpulla, Spiegelman (bib65) 1999; 98 Cantó, Auwerx (bib5) 2011; 26 Hardie (bib18) 2011; 25 Weisberg, McCann, Desai, Rosenbaum, Leibel, Ferrante (bib64) 2003; 112 Ravussin, Lillioja, Knowler, Christin, Freymond, Abbott, Boyce, Howard, Bogardus (bib51) 1988; 318 Ma, Helgason, Phung, Quan, Iyer, Lee, Bowman, Starovasnik, Dueber (bib39) 2012; 109 Gauthier, O’Brien, Bigornia, Mott, Cacicedo, Xu, Gokce, Apovian, Ruderman (bib14) 2011; 404 Arkan, Hevener, Greten, Maeda, Li, Long, Wynshaw-Boris, Poli, Olefsky, Karin (bib1) 2005; 11 O’Neill, Hardie (bib45) 2013; 493 Xu, Barnes, Yang, Tan, Yang, Chou, Sole, Nichols, Ross, Tartaglia, Chen (bib66) 2003; 112 Clément, Meloche, Servant (bib9) 2008; 18 Perry, Chow, Goodnough, Yeh, Cheng (bib48) 2004; 199 Ravussin (10.1016/j.cell.2018.01.007_bib51) 1988; 318 Hotamisligil (10.1016/j.cell.2018.01.007_bib22) 1993; 259 Gauthier (10.1016/j.cell.2018.01.007_bib14) 2011; 404 Baker (10.1016/j.cell.2018.01.007_bib3) 2011; 13 Hotamisligil (10.1016/j.cell.2018.01.007_bib25) 1996; 271 Jeffery (10.1016/j.cell.2018.01.007_bib27) 2014; 3 Lawrence (10.1016/j.cell.2018.01.007_bib35) 2009; 1 Larson-Meyer (10.1016/j.cell.2018.01.007_bib34) 2006; 29 Gwinn (10.1016/j.cell.2018.01.007_bib16) 2008; 30 Shaw (10.1016/j.cell.2018.01.007_bib59) 2004; 101 Daval (10.1016/j.cell.2018.01.007_bib11) 2006; 574 Cantó (10.1016/j.cell.2018.01.007_bib4) 2009; 20 Guilherme (10.1016/j.cell.2018.01.007_bib15) 2008; 9 Choi (10.1016/j.cell.2018.01.007_bib8) 2015; 113 Weisberg (10.1016/j.cell.2018.01.007_bib64) 2003; 112 Cauwels (10.1016/j.cell.2018.01.007_bib6) 2014; 5 Garcia-Haro (10.1016/j.cell.2018.01.007_bib13) 2010; 24 Coleman (10.1016/j.cell.2018.01.007_bib10) 1978; 14 Lumeng (10.1016/j.cell.2018.01.007_bib38) 2011; 121 Kazak (10.1016/j.cell.2018.01.007_bib31) 2015; 163 Bachman (10.1016/j.cell.2018.01.007_bib2) 2002; 297 Perry (10.1016/j.cell.2018.01.007_bib48) 2004; 199 Viollet (10.1016/j.cell.2018.01.007_bib62) 2010; 45 Salminen (10.1016/j.cell.2018.01.007_bib57) 2011; 89 Puigserver (10.1016/j.cell.2018.01.007_bib49) 1998; 92 Mottillo (10.1016/j.cell.2018.01.007_bib43) 2016; 24 Xu (10.1016/j.cell.2018.01.007_bib67) 2012; 53 Mowers (10.1016/j.cell.2018.01.007_bib44) 2013; 2 Reznick (10.1016/j.cell.2018.01.007_bib54) 2006; 574 Mihaylova (10.1016/j.cell.2018.01.007_bib42) 2011; 13 O’Neill (10.1016/j.cell.2018.01.007_bib45) 2013; 493 Huang (10.1016/j.cell.2018.01.007_bib26) 2015; 34 Jin (10.1016/j.cell.2018.01.007_bib28) 2012; 13 Hotamisligil (10.1016/j.cell.2018.01.007_bib23) 1994; 91 Kazak (10.1016/j.cell.2018.01.007_bib32) 2017; 26 Wan (10.1016/j.cell.2018.01.007_bib63) 2014; 22 Kanda (10.1016/j.cell.2018.01.007_bib30) 2006; 116 Chiang (10.1016/j.cell.2018.01.007_bib7) 2009; 138 Roberts (10.1016/j.cell.2018.01.007_bib55) 1998; 22 Hardie (10.1016/j.cell.2018.01.007_bib19) 2012; 13 Reilly (10.1016/j.cell.2018.01.007_bib53) 2013; 19 Suzuki (10.1016/j.cell.2018.01.007_bib61) 2013; 50 Delhase (10.1016/j.cell.2018.01.007_bib12) 2012; 109 Cantó (10.1016/j.cell.2018.01.007_bib5) 2011; 26 Hall (10.1016/j.cell.2018.01.007_bib17) 2012; 95 Lohman (10.1016/j.cell.2018.01.007_bib37) 2015; 6 Hill (10.1016/j.cell.2018.01.007_bib21) 2012; 126 Oral (10.1016/j.cell.2018.01.007_bib46) 2017; 26 Kim (10.1016/j.cell.2018.01.007_bib33) 2011; 13 Pazos (10.1016/j.cell.2018.01.007_bib47) 2015; 5 Kamei (10.1016/j.cell.2018.01.007_bib29) 2006; 281 Martin (10.1016/j.cell.2018.01.007_bib41) 2007; 15 Zarnegar (10.1016/j.cell.2018.01.007_bib68) 2008; 105 Rasmussen (10.1016/j.cell.2018.01.007_bib50) 2007; 85 Wu (10.1016/j.cell.2018.01.007_bib65) 1999; 98 Hawley (10.1016/j.cell.2018.01.007_bib20) 2014; 459 Reilly (10.1016/j.cell.2018.01.007_bib52) 2017; 13 Hardie (10.1016/j.cell.2018.01.007_bib18) 2011; 25 Xu (10.1016/j.cell.2018.01.007_bib66) 2003; 112 Leibel (10.1016/j.cell.2018.01.007_bib36) 1995; 332 Martin (10.1016/j.cell.2018.01.007_bib40) 2006; 281 Hotamisligil (10.1016/j.cell.2018.01.007_bib24) 1995; 95 Ma (10.1016/j.cell.2018.01.007_bib39) 2012; 109 Sun (10.1016/j.cell.2018.01.007_bib60) 2011; 21 Russell (10.1016/j.cell.2018.01.007_bib56) 2013; 15 Zhao (10.1016/j.cell.2018.01.007_bib69) 2013; 2 Arkan (10.1016/j.cell.2018.01.007_bib1) 2005; 11 Clément (10.1016/j.cell.2018.01.007_bib9) 2008; 18 Schnurr (10.1016/j.cell.2018.01.007_bib58) 2000; 165 29472713 - Nat Rev Endocrinol. 2018 Apr;14(4):192
References_xml	– volume: 109 start-page: E177 year: 2012 end-page: E186 ident: bib12 article-title: TANK-binding kinase 1 (TBK1) controls cell survival through PAI-2/serpinB2 and transglutaminase 2 publication-title: Proc. Natl. Acad. Sci. USA – volume: 15 start-page: 741 year: 2013 end-page: 750 ident: bib56 article-title: ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase publication-title: Nat. Cell Biol. – volume: 112 start-page: 1796 year: 2003 end-page: 1808 ident: bib64 article-title: Obesity is associated with macrophage accumulation in adipose tissue publication-title: J. Clin. Invest. – volume: 91 start-page: 4854 year: 1994 end-page: 4858 ident: bib23 article-title: Tumor necrosis factor alpha inhibits signaling from the insulin receptor publication-title: Proc. Natl. Acad. Sci. USA – volume: 25 start-page: 1895 year: 2011 end-page: 1908 ident: bib18 article-title: AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function publication-title: Genes Dev. – volume: 15 start-page: 2964 year: 2007 end-page: 2973 ident: bib41 article-title: Effect of calorie restriction on resting metabolic rate and spontaneous physical activity publication-title: Obesity (Silver Spring) – volume: 98 start-page: 115 year: 1999 end-page: 124 ident: bib65 article-title: Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1 publication-title: Cell – volume: 14 start-page: 141 year: 1978 end-page: 148 ident: bib10 article-title: Obese and diabetes: two mutant genes causing diabetes-obesity syndromes in mice publication-title: Diabetologia – volume: 29 start-page: 1337 year: 2006 end-page: 1344 ident: bib34 article-title: Effect of calorie restriction with or without exercise on insulin sensitivity, beta-cell function, fat cell size, and ectopic lipid in overweight subjects publication-title: Diabetes Care – volume: 13 start-page: 633 year: 2017 end-page: 643 ident: bib52 article-title: Adapting to obesity with adipose tissue inflammation publication-title: Nat. Rev. Endocrinol. – volume: 95 start-page: 989 year: 2012 end-page: 994 ident: bib17 article-title: Energy balance and its components: implications for body weight regulation publication-title: Am. J. Clin. Nutr. – volume: 199 start-page: 1651 year: 2004 end-page: 1658 ident: bib48 article-title: Differential requirement for TANK-binding kinase-1 in type I interferon responses to toll-like receptor activation and viral infection publication-title: J. Exp. Med. – volume: 574 start-page: 33 year: 2006 end-page: 39 ident: bib54 article-title: The role of AMP-activated protein kinase in mitochondrial biogenesis publication-title: J. Physiol. – volume: 404 start-page: 382 year: 2011 end-page: 387 ident: bib14 article-title: Decreased AMP-activated protein kinase activity is associated with increased inflammation in visceral adipose tissue and with whole-body insulin resistance in morbidly obese humans publication-title: Biochem. Biophys. Res. Commun. – volume: 13 start-page: 132 year: 2011 end-page: 141 ident: bib33 article-title: AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1 publication-title: Nat. Cell Biol. – volume: 574 start-page: 55 year: 2006 end-page: 62 ident: bib11 article-title: Functions of AMP-activated protein kinase in adipose tissue publication-title: J. Physiol. – volume: 24 start-page: 5080 year: 2010 end-page: 5091 ident: bib13 article-title: The PP1-R6 protein phosphatase holoenzyme is involved in the glucose-induced dephosphorylation and inactivation of AMP-activated protein kinase, a key regulator of insulin secretion, in MIN6 beta cells publication-title: FASEB J. – volume: 281 start-page: 18933 year: 2006 end-page: 18941 ident: bib40 article-title: Diet-induced obesity alters AMP kinase activity in hypothalamus and skeletal muscle publication-title: J. Biol. Chem. – volume: 13 start-page: 1016 year: 2011 end-page: 1023 ident: bib42 article-title: The AMPK signalling pathway coordinates cell growth, autophagy and metabolism publication-title: Nat. Cell Biol. – volume: 85 start-page: 1014 year: 2007 end-page: 1022 ident: bib50 article-title: Effect on 24-h energy expenditure of a moderate-fat diet high in monounsaturated fatty acids compared with that of a low-fat, carbohydrate-rich diet: a 6-mo controlled dietary intervention trial publication-title: Am. J. Clin. Nutr. – volume: 297 start-page: 843 year: 2002 end-page: 845 ident: bib2 article-title: betaAR signaling required for diet-induced thermogenesis and obesity resistance publication-title: Science – volume: 121 start-page: 2111 year: 2011 end-page: 2117 ident: bib38 article-title: Inflammatory links between obesity and metabolic disease publication-title: J. Clin. Invest. – volume: 95 start-page: 2409 year: 1995 end-page: 2415 ident: bib24 article-title: Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance publication-title: J. Clin. Invest. – volume: 19 start-page: 313 year: 2013 end-page: 321 ident: bib53 article-title: An inhibitor of the protein kinases TBK1 and IKK-ε improves obesity-related metabolic dysfunctions in mice publication-title: Nat. Med. – volume: 11 start-page: 191 year: 2005 end-page: 198 ident: bib1 article-title: IKK-beta links inflammation to obesity-induced insulin resistance publication-title: Nat. Med. – volume: 493 start-page: 346 year: 2013 end-page: 355 ident: bib45 article-title: Metabolism of inflammation limited by AMPK and pseudo-starvation publication-title: Nature – volume: 53 start-page: 792 year: 2012 end-page: 801 ident: bib67 article-title: Insulin sensitive and resistant obesity in humans: AMPK activity, oxidative stress, and depot-specific changes in gene expression in adipose tissue publication-title: J. Lipid Res. – volume: 18 start-page: 889 year: 2008 end-page: 899 ident: bib9 article-title: The IKK-related kinases: from innate immunity to oncogenesis publication-title: Cell Res. – volume: 13 start-page: 11 year: 2011 end-page: 22 ident: bib3 article-title: NF-κB, inflammation, and metabolic disease publication-title: Cell Metab. – volume: 459 start-page: 275 year: 2014 end-page: 287 ident: bib20 article-title: Phosphorylation by Akt within the ST loop of AMPK-α1 down-regulates its activation in tumour cells publication-title: Biochem. J. – volume: 20 start-page: 98 year: 2009 end-page: 105 ident: bib4 article-title: PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditure publication-title: Curr. Opin. Lipidol. – volume: 26 start-page: 660 year: 2017 end-page: 671.e3 ident: bib32 article-title: Genetic depletion of adipocyte creatine metabolism inhibits diet-induced thermogenesis and drives obesity publication-title: Cell Metab. – volume: 24 start-page: 118 year: 2016 end-page: 129 ident: bib43 article-title: Lack of adipocyte AMPK exacerbates insulin resistance and hepatic steatosis through brown and beige adipose tissue function publication-title: Cell Metab. – volume: 89 start-page: 667 year: 2011 end-page: 676 ident: bib57 article-title: AMP-activated protein kinase inhibits NF-κB signaling and inflammation: impact on healthspan and lifespan publication-title: J. Mol. Med. (Berl.) – volume: 112 start-page: 1821 year: 2003 end-page: 1830 ident: bib66 article-title: Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance publication-title: J. Clin. Invest. – volume: 26 start-page: 214 year: 2011 end-page: 224 ident: bib5 article-title: Calorie restriction: is AMPK a key sensor and effector? publication-title: Physiology (Bethesda) – volume: 332 start-page: 621 year: 1995 end-page: 628 ident: bib36 article-title: Changes in energy expenditure resulting from altered body weight publication-title: N. Engl. J. Med. – volume: 34 start-page: 133 year: 2015 end-page: 141 ident: bib26 article-title: AMPK activation inhibits expression of proinflammatory mediators through downregulation of PI3K/p38 MAPK and NF-κB signaling in murine macrophages publication-title: DNA Cell Biol. – volume: 9 start-page: 367 year: 2008 end-page: 377 ident: bib15 article-title: Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes publication-title: Nat. Rev. Mol. Cell Biol. – volume: 116 start-page: 1494 year: 2006 end-page: 1505 ident: bib30 article-title: MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity publication-title: J. Clin. Invest. – volume: 2 start-page: e01119 year: 2013 ident: bib44 article-title: Inflammation produces catecholamine resistance in obesity via activation of PDE3B by the protein kinases IKKε and TBK1 publication-title: eLife – volume: 1 start-page: a001651 year: 2009 ident: bib35 article-title: The nuclear factor NF-kappaB pathway in inflammation publication-title: Cold Spring Harb. Perspect. Biol. – volume: 259 start-page: 87 year: 1993 end-page: 91 ident: bib22 article-title: Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance publication-title: Science – volume: 26 start-page: 157 year: 2017 end-page: 170.e7 ident: bib46 article-title: Inhibition of IKKε and TBK1 improves glucose control in a subset of patients with type 2 diabetes publication-title: Cell Metab. – volume: 2 start-page: 161 year: 2013 end-page: 170 ident: bib69 article-title: STAT1, NF-κB and ERKs play a role in the induction of lipocalin-2 expression in adipocytes publication-title: Mol. Metab. – volume: 13 start-page: 251 year: 2012 end-page: 262 ident: bib19 article-title: AMPK: a nutrient and energy sensor that maintains energy homeostasis publication-title: Nat. Rev. Mol. Cell Biol. – volume: 92 start-page: 829 year: 1998 end-page: 839 ident: bib49 article-title: A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis publication-title: Cell – volume: 138 start-page: 961 year: 2009 end-page: 975 ident: bib7 article-title: The protein kinase IKKepsilon regulates energy balance in obese mice publication-title: Cell – volume: 113 start-page: 867 year: 2015 end-page: 877 ident: bib8 article-title: High-fat diet decreases energy expenditure and expression of genes controlling lipid metabolism, mitochondrial function and skeletal system development in the adipose tissue, along with increased expression of extracellular matrix remodelling- and inflammation-related genes publication-title: Br. J. Nutr. – volume: 126 start-page: 126 year: 2012 end-page: 132 ident: bib21 article-title: Energy balance and obesity publication-title: Circulation – volume: 5 start-page: 17977 year: 2015 ident: bib47 article-title: Divergent responses to thermogenic stimuli in BAT and subcutaneous adipose tissue from interleukin 18 and interleukin 18 receptor 1-deficient mice publication-title: Sci. Rep. – volume: 30 start-page: 214 year: 2008 end-page: 226 ident: bib16 article-title: AMPK phosphorylation of raptor mediates a metabolic checkpoint publication-title: Mol. Cell – volume: 6 start-page: 7965 year: 2015 ident: bib37 article-title: Pannexin 1 channels regulate leukocyte emigration through the venous endothelium during acute inflammation publication-title: Nat. Commun. – volume: 318 start-page: 467 year: 1988 end-page: 472 ident: bib51 article-title: Reduced rate of energy expenditure as a risk factor for body-weight gain publication-title: N. Engl. J. Med. – volume: 50 start-page: 407 year: 2013 end-page: 419 ident: bib61 article-title: Inhibition of AMPK catabolic action by GSK3 publication-title: Mol. Cell – volume: 45 start-page: 276 year: 2010 end-page: 295 ident: bib62 article-title: AMPK inhibition in health and disease publication-title: Crit. Rev. Biochem. Mol. Biol. – volume: 105 start-page: 3503 year: 2008 end-page: 3508 ident: bib68 article-title: Control of canonical NF-kappaB activation through the NIK-IKK complex pathway publication-title: Proc. Natl. Acad. Sci. USA – volume: 165 start-page: 4704 year: 2000 end-page: 4709 ident: bib58 article-title: Extracellular ATP and TNF-alpha synergize in the activation and maturation of human dendritic cells publication-title: J. Immunol. – volume: 163 start-page: 643 year: 2015 end-page: 655 ident: bib31 article-title: A creatine-driven substrate cycle enhances energy expenditure and thermogenesis in beige fat publication-title: Cell – volume: 3 start-page: 206 year: 2014 end-page: 211 ident: bib27 article-title: Characterization of Cre recombinase models for the study of adipose tissue publication-title: Adipocyte – volume: 5 start-page: e1102 year: 2014 ident: bib6 article-title: Extracellular ATP drives systemic inflammation, tissue damage and mortality publication-title: Cell Death Dis. – volume: 21 start-page: 71 year: 2011 end-page: 85 ident: bib60 article-title: Non-canonical NF-κB signaling pathway publication-title: Cell Res. – volume: 109 start-page: 9378 year: 2012 end-page: 9383 ident: bib39 article-title: Molecular basis of Tank-binding kinase 1 activation by transautophosphorylation publication-title: Proc. Natl. Acad. Sci. USA – volume: 271 start-page: 665 year: 1996 end-page: 668 ident: bib25 article-title: IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance publication-title: Science – volume: 22 start-page: 730 year: 2014 end-page: 738 ident: bib63 article-title: Evidence for the role of AMPK in regulating PGC-1 alpha expression and mitochondrial proteins in mouse epididymal adipose tissue publication-title: Obesity (Silver Spring) – volume: 101 start-page: 3329 year: 2004 end-page: 3335 ident: bib59 article-title: The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress publication-title: Proc. Natl. Acad. Sci. USA – volume: 13 start-page: 1101 year: 2012 end-page: 1109 ident: bib28 article-title: The kinase TBK1 controls IgA class switching by negatively regulating noncanonical NF-κB signaling publication-title: Nat. Immunol. – volume: 22 start-page: 385 year: 1998 end-page: 386 ident: bib55 article-title: Excess energy intake and low energy expenditure as predictors of obesity publication-title: Int. J. Obes. Relat. Metab. Disord. – volume: 281 start-page: 26602 year: 2006 end-page: 26614 ident: bib29 article-title: Overexpression of monocyte chemoattractant protein-1 in adipose tissues causes macrophage recruitment and insulin resistance publication-title: J. Biol. Chem. – volume: 50 start-page: 407 year: 2013 ident: 10.1016/j.cell.2018.01.007_bib61 article-title: Inhibition of AMPK catabolic action by GSK3 publication-title: Mol. Cell doi: 10.1016/j.molcel.2013.03.022 – volume: 3 start-page: 206 year: 2014 ident: 10.1016/j.cell.2018.01.007_bib27 article-title: Characterization of Cre recombinase models for the study of adipose tissue publication-title: Adipocyte doi: 10.4161/adip.29674 – volume: 22 start-page: 385 year: 1998 ident: 10.1016/j.cell.2018.01.007_bib55 article-title: Excess energy intake and low energy expenditure as predictors of obesity publication-title: Int. J. Obes. Relat. Metab. Disord. doi: 10.1038/sj.ijo.0800640 – volume: 21 start-page: 71 year: 2011 ident: 10.1016/j.cell.2018.01.007_bib60 article-title: Non-canonical NF-κB signaling pathway publication-title: Cell Res. doi: 10.1038/cr.2010.177 – volume: 112 start-page: 1821 year: 2003 ident: 10.1016/j.cell.2018.01.007_bib66 article-title: Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance publication-title: J. Clin. Invest. doi: 10.1172/JCI200319451 – volume: 92 start-page: 829 year: 1998 ident: 10.1016/j.cell.2018.01.007_bib49 article-title: A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis publication-title: Cell doi: 10.1016/S0092-8674(00)81410-5 – volume: 24 start-page: 5080 year: 2010 ident: 10.1016/j.cell.2018.01.007_bib13 article-title: The PP1-R6 protein phosphatase holoenzyme is involved in the glucose-induced dephosphorylation and inactivation of AMP-activated protein kinase, a key regulator of insulin secretion, in MIN6 beta cells publication-title: FASEB J. – volume: 112 start-page: 1796 year: 2003 ident: 10.1016/j.cell.2018.01.007_bib64 article-title: Obesity is associated with macrophage accumulation in adipose tissue publication-title: J. Clin. Invest. doi: 10.1172/JCI200319246 – volume: 53 start-page: 792 year: 2012 ident: 10.1016/j.cell.2018.01.007_bib67 article-title: Insulin sensitive and resistant obesity in humans: AMPK activity, oxidative stress, and depot-specific changes in gene expression in adipose tissue publication-title: J. Lipid Res. doi: 10.1194/jlr.P022905 – volume: 332 start-page: 621 year: 1995 ident: 10.1016/j.cell.2018.01.007_bib36 article-title: Changes in energy expenditure resulting from altered body weight publication-title: N. Engl. J. Med. doi: 10.1056/NEJM199503093321001 – volume: 493 start-page: 346 year: 2013 ident: 10.1016/j.cell.2018.01.007_bib45 article-title: Metabolism of inflammation limited by AMPK and pseudo-starvation publication-title: Nature doi: 10.1038/nature11862 – volume: 116 start-page: 1494 year: 2006 ident: 10.1016/j.cell.2018.01.007_bib30 article-title: MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity publication-title: J. Clin. Invest. doi: 10.1172/JCI26498 – volume: 91 start-page: 4854 year: 1994 ident: 10.1016/j.cell.2018.01.007_bib23 article-title: Tumor necrosis factor alpha inhibits signaling from the insulin receptor publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.91.11.4854 – volume: 13 start-page: 132 year: 2011 ident: 10.1016/j.cell.2018.01.007_bib33 article-title: AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1 publication-title: Nat. Cell Biol. doi: 10.1038/ncb2152 – volume: 13 start-page: 633 year: 2017 ident: 10.1016/j.cell.2018.01.007_bib52 article-title: Adapting to obesity with adipose tissue inflammation publication-title: Nat. Rev. Endocrinol. doi: 10.1038/nrendo.2017.90 – volume: 113 start-page: 867 year: 2015 ident: 10.1016/j.cell.2018.01.007_bib8 publication-title: Br. J. Nutr. doi: 10.1017/S0007114515000100 – volume: 98 start-page: 115 year: 1999 ident: 10.1016/j.cell.2018.01.007_bib65 article-title: Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1 publication-title: Cell doi: 10.1016/S0092-8674(00)80611-X – volume: 6 start-page: 7965 year: 2015 ident: 10.1016/j.cell.2018.01.007_bib37 article-title: Pannexin 1 channels regulate leukocyte emigration through the venous endothelium during acute inflammation publication-title: Nat. Commun. doi: 10.1038/ncomms8965 – volume: 5 start-page: 17977 year: 2015 ident: 10.1016/j.cell.2018.01.007_bib47 article-title: Divergent responses to thermogenic stimuli in BAT and subcutaneous adipose tissue from interleukin 18 and interleukin 18 receptor 1-deficient mice publication-title: Sci. Rep. doi: 10.1038/srep17977 – volume: 13 start-page: 251 year: 2012 ident: 10.1016/j.cell.2018.01.007_bib19 article-title: AMPK: a nutrient and energy sensor that maintains energy homeostasis publication-title: Nat. Rev. Mol. Cell Biol. doi: 10.1038/nrm3311 – volume: 85 start-page: 1014 year: 2007 ident: 10.1016/j.cell.2018.01.007_bib50 article-title: Effect on 24-h energy expenditure of a moderate-fat diet high in monounsaturated fatty acids compared with that of a low-fat, carbohydrate-rich diet: a 6-mo controlled dietary intervention trial publication-title: Am. J. Clin. Nutr. doi: 10.1093/ajcn/85.4.1014 – volume: 19 start-page: 313 year: 2013 ident: 10.1016/j.cell.2018.01.007_bib53 article-title: An inhibitor of the protein kinases TBK1 and IKK-ε improves obesity-related metabolic dysfunctions in mice publication-title: Nat. Med. doi: 10.1038/nm.3082 – volume: 95 start-page: 2409 year: 1995 ident: 10.1016/j.cell.2018.01.007_bib24 article-title: Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance publication-title: J. Clin. Invest. doi: 10.1172/JCI117936 – volume: 2 start-page: 161 year: 2013 ident: 10.1016/j.cell.2018.01.007_bib69 article-title: STAT1, NF-κB and ERKs play a role in the induction of lipocalin-2 expression in adipocytes publication-title: Mol. Metab. doi: 10.1016/j.molmet.2013.04.003 – volume: 25 start-page: 1895 year: 2011 ident: 10.1016/j.cell.2018.01.007_bib18 article-title: AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function publication-title: Genes Dev. doi: 10.1101/gad.17420111 – volume: 13 start-page: 1016 year: 2011 ident: 10.1016/j.cell.2018.01.007_bib42 article-title: The AMPK signalling pathway coordinates cell growth, autophagy and metabolism publication-title: Nat. Cell Biol. doi: 10.1038/ncb2329 – volume: 281 start-page: 26602 year: 2006 ident: 10.1016/j.cell.2018.01.007_bib29 article-title: Overexpression of monocyte chemoattractant protein-1 in adipose tissues causes macrophage recruitment and insulin resistance publication-title: J. Biol. Chem. doi: 10.1074/jbc.M601284200 – volume: 574 start-page: 33 year: 2006 ident: 10.1016/j.cell.2018.01.007_bib54 article-title: The role of AMP-activated protein kinase in mitochondrial biogenesis publication-title: J. Physiol. doi: 10.1113/jphysiol.2006.109512 – volume: 26 start-page: 214 year: 2011 ident: 10.1016/j.cell.2018.01.007_bib5 article-title: Calorie restriction: is AMPK a key sensor and effector? publication-title: Physiology (Bethesda) – volume: 13 start-page: 11 year: 2011 ident: 10.1016/j.cell.2018.01.007_bib3 article-title: NF-κB, inflammation, and metabolic disease publication-title: Cell Metab. doi: 10.1016/j.cmet.2010.12.008 – volume: 24 start-page: 118 year: 2016 ident: 10.1016/j.cell.2018.01.007_bib43 article-title: Lack of adipocyte AMPK exacerbates insulin resistance and hepatic steatosis through brown and beige adipose tissue function publication-title: Cell Metab. doi: 10.1016/j.cmet.2016.06.006 – volume: 14 start-page: 141 year: 1978 ident: 10.1016/j.cell.2018.01.007_bib10 article-title: Obese and diabetes: two mutant genes causing diabetes-obesity syndromes in mice publication-title: Diabetologia doi: 10.1007/BF00429772 – volume: 15 start-page: 741 year: 2013 ident: 10.1016/j.cell.2018.01.007_bib56 article-title: ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase publication-title: Nat. Cell Biol. doi: 10.1038/ncb2757 – volume: 101 start-page: 3329 year: 2004 ident: 10.1016/j.cell.2018.01.007_bib59 article-title: The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.0308061100 – volume: 20 start-page: 98 year: 2009 ident: 10.1016/j.cell.2018.01.007_bib4 article-title: PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditure publication-title: Curr. Opin. Lipidol. doi: 10.1097/MOL.0b013e328328d0a4 – volume: 9 start-page: 367 year: 2008 ident: 10.1016/j.cell.2018.01.007_bib15 article-title: Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes publication-title: Nat. Rev. Mol. Cell Biol. doi: 10.1038/nrm2391 – volume: 18 start-page: 889 year: 2008 ident: 10.1016/j.cell.2018.01.007_bib9 article-title: The IKK-related kinases: from innate immunity to oncogenesis publication-title: Cell Res. doi: 10.1038/cr.2008.273 – volume: 2 start-page: e01119 year: 2013 ident: 10.1016/j.cell.2018.01.007_bib44 article-title: Inflammation produces catecholamine resistance in obesity via activation of PDE3B by the protein kinases IKKε and TBK1 publication-title: eLife doi: 10.7554/eLife.01119 – volume: 13 start-page: 1101 year: 2012 ident: 10.1016/j.cell.2018.01.007_bib28 article-title: The kinase TBK1 controls IgA class switching by negatively regulating noncanonical NF-κB signaling publication-title: Nat. Immunol. doi: 10.1038/ni.2423 – volume: 1 start-page: a001651 year: 2009 ident: 10.1016/j.cell.2018.01.007_bib35 article-title: The nuclear factor NF-kappaB pathway in inflammation publication-title: Cold Spring Harb. Perspect. Biol. doi: 10.1101/cshperspect.a001651 – volume: 15 start-page: 2964 year: 2007 ident: 10.1016/j.cell.2018.01.007_bib41 article-title: Effect of calorie restriction on resting metabolic rate and spontaneous physical activity publication-title: Obesity (Silver Spring) doi: 10.1038/oby.2007.354 – volume: 163 start-page: 643 year: 2015 ident: 10.1016/j.cell.2018.01.007_bib31 article-title: A creatine-driven substrate cycle enhances energy expenditure and thermogenesis in beige fat publication-title: Cell doi: 10.1016/j.cell.2015.09.035 – volume: 34 start-page: 133 year: 2015 ident: 10.1016/j.cell.2018.01.007_bib26 article-title: AMPK activation inhibits expression of proinflammatory mediators through downregulation of PI3K/p38 MAPK and NF-κB signaling in murine macrophages publication-title: DNA Cell Biol. doi: 10.1089/dna.2014.2630 – volume: 459 start-page: 275 year: 2014 ident: 10.1016/j.cell.2018.01.007_bib20 article-title: Phosphorylation by Akt within the ST loop of AMPK-α1 down-regulates its activation in tumour cells publication-title: Biochem. J. doi: 10.1042/BJ20131344 – volume: 574 start-page: 55 year: 2006 ident: 10.1016/j.cell.2018.01.007_bib11 article-title: Functions of AMP-activated protein kinase in adipose tissue publication-title: J. Physiol. doi: 10.1113/jphysiol.2006.111484 – volume: 404 start-page: 382 year: 2011 ident: 10.1016/j.cell.2018.01.007_bib14 article-title: Decreased AMP-activated protein kinase activity is associated with increased inflammation in visceral adipose tissue and with whole-body insulin resistance in morbidly obese humans publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/j.bbrc.2010.11.127 – volume: 281 start-page: 18933 year: 2006 ident: 10.1016/j.cell.2018.01.007_bib40 article-title: Diet-induced obesity alters AMP kinase activity in hypothalamus and skeletal muscle publication-title: J. Biol. Chem. doi: 10.1074/jbc.M512831200 – volume: 318 start-page: 467 year: 1988 ident: 10.1016/j.cell.2018.01.007_bib51 article-title: Reduced rate of energy expenditure as a risk factor for body-weight gain publication-title: N. Engl. J. Med. doi: 10.1056/NEJM198802253180802 – volume: 5 start-page: e1102 year: 2014 ident: 10.1016/j.cell.2018.01.007_bib6 article-title: Extracellular ATP drives systemic inflammation, tissue damage and mortality publication-title: Cell Death Dis. doi: 10.1038/cddis.2014.70 – volume: 29 start-page: 1337 year: 2006 ident: 10.1016/j.cell.2018.01.007_bib34 article-title: Effect of calorie restriction with or without exercise on insulin sensitivity, beta-cell function, fat cell size, and ectopic lipid in overweight subjects publication-title: Diabetes Care doi: 10.2337/dc05-2565 – volume: 26 start-page: 660 year: 2017 ident: 10.1016/j.cell.2018.01.007_bib32 article-title: Genetic depletion of adipocyte creatine metabolism inhibits diet-induced thermogenesis and drives obesity publication-title: Cell Metab. doi: 10.1016/j.cmet.2017.08.009 – volume: 259 start-page: 87 year: 1993 ident: 10.1016/j.cell.2018.01.007_bib22 article-title: Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance publication-title: Science doi: 10.1126/science.7678183 – volume: 95 start-page: 989 year: 2012 ident: 10.1016/j.cell.2018.01.007_bib17 article-title: Energy balance and its components: implications for body weight regulation publication-title: Am. J. Clin. Nutr. doi: 10.3945/ajcn.112.036350 – volume: 22 start-page: 730 year: 2014 ident: 10.1016/j.cell.2018.01.007_bib63 article-title: Evidence for the role of AMPK in regulating PGC-1 alpha expression and mitochondrial proteins in mouse epididymal adipose tissue publication-title: Obesity (Silver Spring) doi: 10.1002/oby.20605 – volume: 89 start-page: 667 year: 2011 ident: 10.1016/j.cell.2018.01.007_bib57 article-title: AMP-activated protein kinase inhibits NF-κB signaling and inflammation: impact on healthspan and lifespan publication-title: J. Mol. Med. (Berl.) doi: 10.1007/s00109-011-0748-0 – volume: 109 start-page: E177 year: 2012 ident: 10.1016/j.cell.2018.01.007_bib12 article-title: TANK-binding kinase 1 (TBK1) controls cell survival through PAI-2/serpinB2 and transglutaminase 2 publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.1119296109 – volume: 30 start-page: 214 year: 2008 ident: 10.1016/j.cell.2018.01.007_bib16 article-title: AMPK phosphorylation of raptor mediates a metabolic checkpoint publication-title: Mol. Cell doi: 10.1016/j.molcel.2008.03.003 – volume: 271 start-page: 665 year: 1996 ident: 10.1016/j.cell.2018.01.007_bib25 article-title: IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance publication-title: Science doi: 10.1126/science.271.5249.665 – volume: 121 start-page: 2111 year: 2011 ident: 10.1016/j.cell.2018.01.007_bib38 article-title: Inflammatory links between obesity and metabolic disease publication-title: J. Clin. Invest. doi: 10.1172/JCI57132 – volume: 138 start-page: 961 year: 2009 ident: 10.1016/j.cell.2018.01.007_bib7 article-title: The protein kinase IKKepsilon regulates energy balance in obese mice publication-title: Cell doi: 10.1016/j.cell.2009.06.046 – volume: 297 start-page: 843 year: 2002 ident: 10.1016/j.cell.2018.01.007_bib2 article-title: betaAR signaling required for diet-induced thermogenesis and obesity resistance publication-title: Science doi: 10.1126/science.1073160 – volume: 26 start-page: 157 year: 2017 ident: 10.1016/j.cell.2018.01.007_bib46 article-title: Inhibition of IKKε and TBK1 improves glucose control in a subset of patients with type 2 diabetes publication-title: Cell Metab. doi: 10.1016/j.cmet.2017.06.006 – volume: 109 start-page: 9378 year: 2012 ident: 10.1016/j.cell.2018.01.007_bib39 article-title: Molecular basis of Tank-binding kinase 1 activation by transautophosphorylation publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.1121552109 – volume: 199 start-page: 1651 year: 2004 ident: 10.1016/j.cell.2018.01.007_bib48 article-title: Differential requirement for TANK-binding kinase-1 in type I interferon responses to toll-like receptor activation and viral infection publication-title: J. Exp. Med. doi: 10.1084/jem.20040528 – volume: 105 start-page: 3503 year: 2008 ident: 10.1016/j.cell.2018.01.007_bib68 article-title: Control of canonical NF-kappaB activation through the NIK-IKK complex pathway publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.0707959105 – volume: 11 start-page: 191 year: 2005 ident: 10.1016/j.cell.2018.01.007_bib1 article-title: IKK-beta links inflammation to obesity-induced insulin resistance publication-title: Nat. Med. doi: 10.1038/nm1185 – volume: 126 start-page: 126 year: 2012 ident: 10.1016/j.cell.2018.01.007_bib21 article-title: Energy balance and obesity publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.111.087213 – volume: 45 start-page: 276 year: 2010 ident: 10.1016/j.cell.2018.01.007_bib62 article-title: AMPK inhibition in health and disease publication-title: Crit. Rev. Biochem. Mol. Biol. doi: 10.3109/10409238.2010.488215 – volume: 165 start-page: 4704 year: 2000 ident: 10.1016/j.cell.2018.01.007_bib58 article-title: Extracellular ATP and TNF-alpha synergize in the activation and maturation of human dendritic cells publication-title: J. Immunol. doi: 10.4049/jimmunol.165.8.4704 – reference: 29472713 - Nat Rev Endocrinol. 2018 Apr;14(4):192
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Snippet	The noncanonical IKK family member TANK-binding kinase 1 (TBK1) is activated by pro-inflammatory cytokines, but its role in controlling metabolism remains...
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SubjectTerms	adipocytes Adipocytes - metabolism Adipocytes - pathology adipose tissue Adipose Tissue - metabolism Adipose Tissue - pathology AMP-Activated Protein Kinases - genetics AMP-Activated Protein Kinases - metabolism AMPK Animals Autophagy-Related Protein-1 Homolog - genetics Autophagy-Related Protein-1 Homolog - metabolism Cell Line, Transformed cytokine cytokines Dietary Fats - adverse effects Dietary Fats - pharmacology energy expenditure Energy Metabolism enzymes homeostasis inflammation Inflammation - chemically induced Inflammation - genetics Inflammation - metabolism Inflammation - pathology insulin resistance malnutrition Mice Mice, Knockout mitochondria NF-kappa B - genetics NF-kappa B - metabolism NF-kappaB-Inducing Kinase NFκB obesity Oxygen Consumption - drug effects phosphorylation Phosphorylation - drug effects Phosphorylation - genetics protein phosphorylation Protein Serine-Threonine Kinases - genetics Protein Serine-Threonine Kinases - metabolism Signal Transduction transcription factor NF-kappa B
Title	TBK1 at the Crossroads of Inflammation and Energy Homeostasis in Adipose Tissue
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