Receptor palmitoylation and ubiquitination regulate anthrax toxin endocytosis
The anthrax toxin is composed of three independent polypeptide chains. Successful intoxication only occurs when heptamerization of the receptor-binding polypeptide, the protective antigen (PA), allows binding of the two enzymatic subunits before endocytosis. We show that this tailored behavior is ca...
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Published in | The Journal of cell biology Vol. 172; no. 2; pp. 309 - 320 |
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Language | English |
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16.01.2006
The Rockefeller University Press |
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Abstract | The anthrax toxin is composed of three independent polypeptide chains. Successful intoxication only occurs when heptamerization of the receptor-binding polypeptide, the protective antigen (PA), allows binding of the two enzymatic subunits before endocytosis. We show that this tailored behavior is caused by two counteracting posttranslational modifications in the cytoplasmic tail of PA receptors. The receptor is palmitoylated, and this unexpectedly prevents its association with lipid rafts and, thus, its premature ubiquitination. This second modification, which is mediated by the E3 ubiquitin ligase Cbl, only occurs in rafts and is required for rapid endocytosis of the receptor. As a consequence, cells expressing palmitoylation-defective mutant receptors are less sensitive to anthrax toxin because of a lower number of surface receptors as well as premature internalization of PA without a requirement for heptamerization. |
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AbstractList | The anthrax toxin is composed of three independent polypeptide chains. Successful intoxication only occurs when heptamerization of the receptor-binding polypeptide, the protective antigen (PA), allows binding of the two enzymatic subunits before endocytosis. We show that this tailored behavior is caused by two counteracting posttranslational modifications in the cytoplasmic tail of PA receptors. The receptor is palmitoylated, and this unexpectedly prevents its association with lipid rafts and, thus, its premature ubiquitination. This second modification, which is mediated by the E3 ubiquitin ligase Cbl, only occurs in rafts and is required for rapid endocytosis of the receptor. As a consequence, cells expressing palmitoylation-defective mutant receptors are less sensitive to anthrax toxin because of a lower number of surface receptors as well as premature internalization of PA without a requirement for heptamerization. The anthrax toxin is composed of three independent polypeptide chains. Successful intoxication only occurs when heptamerization of the receptor-binding polypeptide, the protective antigen (PA), allows binding of the two enzymatic subunits before endocytosis. We show that this tailored behavior is caused by two counteracting posttranslational modifications in the cytoplasmic tail of PA receptors. The receptor is palmitoylated, and this unexpectedly prevents its association with lipid rafts and, thus, its premature ubiquitination. This second modification, which is mediated by the E3 ubiquitin ligase Cbl, only occurs in rafts and is required for rapid endocytosis of the receptor. As a consequence, cells expressing palmitoylation-defective mutant receptors are less sensitive to anthrax toxin because of a lower number of surface receptors as well as premature internalization of PA without a requirement for heptamerization. [PUBLICATION ABSTRACT] |
Author | van der Goot, F. Gisou Leppla, Stephen H Abrami, Laurence |
AuthorAffiliation | 1 Department of Microbiology and Molecular Medicine, University of Geneva, 1211 Geneva 4, Switzerland 2 Microbial Pathogenesis Section, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 |
AuthorAffiliation_xml | – name: 1 Department of Microbiology and Molecular Medicine, University of Geneva, 1211 Geneva 4, Switzerland – name: 2 Microbial Pathogenesis Section, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 |
Author_xml | – sequence: 1 fullname: Abrami, Laurence – sequence: 2 fullname: Leppla, Stephen H – sequence: 3 fullname: van der Goot, F. Gisou |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/16401723$$D View this record in MEDLINE/PubMed |
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Cites_doi | 10.1086/378781 10.1242/jcs.00989 10.1016/j.mib.2004.12.005 10.1093/emboj/cdf398 10.1038/372055a0 10.1083/jcb.147.1.175 10.1074/jbc.M210321200 10.1016/S1074-7613(00)80606-8 10.1073/pnas.0505865102 10.1146/annurev.cellbio.14.1.111 10.1146/annurev.cellbio.19.110701.154617 10.1042/bj2561021 10.1074/jbc.275.1.261 10.1074/jbc.M104013200 10.1126/science.1113380 10.1038/sj.emboj.7600808 10.1083/jcb.200312072 10.1146/annurev.biochem.73.011303.073954 10.1021/bi026679w 10.1038/sj.emboj.7600724 10.1055/s-0037-1616224 10.1074/jbc.270.12.6838 10.1083/jcb.200502007 10.1016/j.tim.2004.12.004 10.1074/jbc.M509049200 10.1083/jcb.200211018 10.1038/nrm973 10.1242/jcs.01148 10.1128/iai.63.1.82-87.1995 10.1016/S0962-8924(02)00008-9 10.1016/S0076-6879(88)65019-1 10.1093/emboj/16.18.5501 10.1139/o90-029 10.1016/j.neuron.2004.12.005 10.1146/annurev.cellbio.19.111301.140655 10.1126/science.1105654 10.1016/S0021-9258(17)46270-3 10.1073/pnas.051003498 |
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Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Abbreviations used in this paper: ßMCD, β-methylcyclodextrin; CMG2, capillary morphogenesis gene 2; DRM, detergent-resistant membrane; EF, edema factor; Endo H, endoglycosidase H; LF, lethal factor; PA, protective antigen; TEM8, tumor endothelial marker 8; Ub, ubiquitin; WT, wild type. |
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References | 11487015 - Thromb Haemost. 2001 Jul;86(1):266-75 16141341 - Proc Natl Acad Sci U S A. 2005 Sep 13;102(37):13278-83 12973667 - Am J Hum Genet. 2003 Oct;73(4):957-66 15897264 - J Cell Biol. 2005 May 23;169(4):623-33 15603741 - Neuron. 2004 Dec 16;44(6):987-96 15680766 - Trends Microbiol. 2005 Feb;13(2):72-8 12461556 - Nat Rev Mol Cell Biol. 2002 Dec;3(12):893-905 15189153 - Annu Rev Biochem. 2004;73:559-87 11390405 - J Biol Chem. 2001 Aug 24;276(34):31936-44 2190617 - Biochem Cell Biol. 1990 Jan;68(1):221-4 16148945 - EMBO J. 2005 Oct 5;24(19):3353-9 12145200 - EMBO J. 2002 Aug 1;21(15):3989-4000 12468536 - J Biol Chem. 2003 Feb 14;278(7):5227-34 9891780 - Annu Rev Cell Dev Biol. 1998;14:111-36 11248052 - Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3180-4 7969419 - Nature. 1994 Nov 3;372(6501):55-63 12564925 - Biochemistry. 2003 Feb 11;42(5):1227-33 15128873 - J Cell Sci. 2004 May 15;117(Pt 12):2557-68 15337774 - J Cell Biol. 2004 Aug 30;166(5):645-51 10617614 - J Biol Chem. 2000 Jan 7;275(1):261-70 2398066 - J Biol Chem. 1990 Sep 25;265(27):16644-55 15705808 - Science. 2005 Mar 18;307(5716):1746-52 12480338 - Trends Cell Biol. 2003 Jan;13(1):32-42 14570563 - Annu Rev Cell Dev Biol. 2003;19:45-70 10508864 - J Cell Biol. 1999 Oct 4;147(1):175-84 15694864 - Curr Opin Microbiol. 2005 Feb;8(1):106-12 9312009 - EMBO J. 1997 Sep 15;16(18):5501-8 2852000 - Biochem J. 1988 Dec 15;256(3):1021-7 14730009 - J Cell Sci. 2004 Feb 1;117(Pt 4):521-6 14679291 - Sci STKE. 2003 Dec 16;2003(213):re17 16051798 - Science. 2005 Jul 29;309(5735):777-81 15973437 - EMBO J. 2005 Jul 20;24(14):2524-32 16183642 - J Biol Chem. 2005 Nov 25;280(47):39417-22 7806387 - Infect Immun. 1995 Jan;63(1):82-7 3148094 - Methods Enzymol. 1988;165:103-16 14570567 - Annu Rev Cell Dev Biol. 2003;19:141-72 7896831 - J Biol Chem. 1995 Mar 24;270(12):6838-42 9729044 - Immunity. 1998 Aug;9(2):239-46 12551953 - J Cell Biol. 2003 Feb 3;160(3):321-8 (2023072910091668700_BIB39) 1998; 9 (2023072910091668700_BIB24) 2003; 278 (2023072910091668700_BIB11) 2003; 73 (2023072910091668700_BIB25) 1988; 256 (2023072910091668700_BIB33) 2001; 86 (2023072910091668700_BIB18) 2003; 19 (2023072910091668700_BIB9) 2003; 19 (2023072910091668700_BIB21) 2001; 98 (2023072910091668700_BIB17) 2004; 117 (2023072910091668700_BIB1) 1999; 147 (2023072910091668700_BIB23) 2004; 117 (2023072910091668700_BIB35) 2005; 24 (2023072910091668700_BIB3) 2004; 166 (2023072910091668700_BIB6) 2003; 13 (2023072910091668700_BIB27) 2003 (2023072910091668700_BIB16) 2005; 24 (2023072910091668700_BIB20) 2005; 309 (2023072910091668700_BIB5) 1990; 265 (2023072910091668700_BIB7) 1998; 14 (2023072910091668700_BIB22) 1988; 165 (2023072910091668700_BIB8) 1990; 68 (2023072910091668700_BIB29) 2005; 307 (2023072910091668700_BIB4) 2005; 13 (2023072910091668700_BIB15) 1995; 63 (2023072910091668700_BIB37) 2003; 42 (2023072910091668700_BIB38) 2005; 280 (2023072910091668700_BIB12) 2005; 169 (2023072910091668700_BIB19) 2002; 3 (2023072910091668700_BIB32) 2005; 8 (2023072910091668700_BIB34) 2004; 73 (2023072910091668700_BIB13) 2002; 21 (2023072910091668700_BIB31) 1997; 16 (2023072910091668700_BIB28) 2005; 102 (2023072910091668700_BIB36) 2000; 275 (2023072910091668700_BIB30) 1994; 372 (2023072910091668700_BIB2) 2003; 160 (2023072910091668700_BIB10) 1995; 270 (2023072910091668700_BIB14) 2004; 44 (2023072910091668700_BIB26) 2001; 276 |
References_xml | – volume: 73 start-page: 957 year: 2003 ident: 2023072910091668700_BIB11 publication-title: Am. J. Hum. Genet. doi: 10.1086/378781 – volume: 117 start-page: 521 year: 2004 ident: 2023072910091668700_BIB23 publication-title: J. Cell Sci. doi: 10.1242/jcs.00989 – volume: 8 start-page: 106 year: 2005 ident: 2023072910091668700_BIB32 publication-title: Curr. Opin. Microbiol. doi: 10.1016/j.mib.2004.12.005 – volume: 21 start-page: 3989 year: 2002 ident: 2023072910091668700_BIB13 publication-title: EMBO J. doi: 10.1093/emboj/cdf398 – volume: 372 start-page: 55 year: 1994 ident: 2023072910091668700_BIB30 publication-title: Nature. doi: 10.1038/372055a0 – year: 2003 ident: 2023072910091668700_BIB27 publication-title: Sci. STKE. – volume: 147 start-page: 175 year: 1999 ident: 2023072910091668700_BIB1 publication-title: J. Cell Biol. doi: 10.1083/jcb.147.1.175 – volume: 278 start-page: 5227 year: 2003 ident: 2023072910091668700_BIB24 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M210321200 – volume: 9 start-page: 239 year: 1998 ident: 2023072910091668700_BIB39 publication-title: Immunity. doi: 10.1016/S1074-7613(00)80606-8 – volume: 102 start-page: 13278 year: 2005 ident: 2023072910091668700_BIB28 publication-title: Proc. Natl. Acad. Sci. USA. doi: 10.1073/pnas.0505865102 – volume: 14 start-page: 111 year: 1998 ident: 2023072910091668700_BIB7 publication-title: Annu. Rev. Cell Dev. Biol. doi: 10.1146/annurev.cellbio.14.1.111 – volume: 19 start-page: 141 year: 2003 ident: 2023072910091668700_BIB18 publication-title: Annu. Rev. Cell Dev. Biol. doi: 10.1146/annurev.cellbio.19.110701.154617 – volume: 256 start-page: 1021 year: 1988 ident: 2023072910091668700_BIB25 publication-title: Biochem. J. doi: 10.1042/bj2561021 – volume: 275 start-page: 261 year: 2000 ident: 2023072910091668700_BIB36 publication-title: J. Biol. Chem. doi: 10.1074/jbc.275.1.261 – volume: 276 start-page: 31936 year: 2001 ident: 2023072910091668700_BIB26 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M104013200 – volume: 309 start-page: 777 year: 2005 ident: 2023072910091668700_BIB20 publication-title: Science. doi: 10.1126/science.1113380 – volume: 24 start-page: 3353 year: 2005 ident: 2023072910091668700_BIB16 publication-title: EMBO J. doi: 10.1038/sj.emboj.7600808 – volume: 166 start-page: 645 year: 2004 ident: 2023072910091668700_BIB3 publication-title: J. Cell Biol. doi: 10.1083/jcb.200312072 – volume: 73 start-page: 559 year: 2004 ident: 2023072910091668700_BIB34 publication-title: Annu. Rev. Biochem. doi: 10.1146/annurev.biochem.73.011303.073954 – volume: 42 start-page: 1227 year: 2003 ident: 2023072910091668700_BIB37 publication-title: Biochemistry. doi: 10.1021/bi026679w – volume: 24 start-page: 2524 year: 2005 ident: 2023072910091668700_BIB35 publication-title: EMBO J. doi: 10.1038/sj.emboj.7600724 – volume: 86 start-page: 266 year: 2001 ident: 2023072910091668700_BIB33 publication-title: Thromb. Haemost. doi: 10.1055/s-0037-1616224 – volume: 270 start-page: 6838 year: 1995 ident: 2023072910091668700_BIB10 publication-title: J. Biol. Chem. doi: 10.1074/jbc.270.12.6838 – volume: 169 start-page: 623 year: 2005 ident: 2023072910091668700_BIB12 publication-title: J. Cell Biol. doi: 10.1083/jcb.200502007 – volume: 13 start-page: 72 year: 2005 ident: 2023072910091668700_BIB4 publication-title: Trends Microbiol. doi: 10.1016/j.tim.2004.12.004 – volume: 280 start-page: 39417 year: 2005 ident: 2023072910091668700_BIB38 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M509049200 – volume: 160 start-page: 321 year: 2003 ident: 2023072910091668700_BIB2 publication-title: J. Cell Biol. doi: 10.1083/jcb.200211018 – volume: 3 start-page: 893 year: 2002 ident: 2023072910091668700_BIB19 publication-title: Nat. Rev. Mol. Cell Biol. doi: 10.1038/nrm973 – volume: 117 start-page: 2557 year: 2004 ident: 2023072910091668700_BIB17 publication-title: J. Cell Sci. doi: 10.1242/jcs.01148 – volume: 63 start-page: 82 year: 1995 ident: 2023072910091668700_BIB15 publication-title: Infect. Immun. doi: 10.1128/iai.63.1.82-87.1995 – volume: 13 start-page: 32 year: 2003 ident: 2023072910091668700_BIB6 publication-title: Trends Cell Biol. doi: 10.1016/S0962-8924(02)00008-9 – volume: 165 start-page: 103 year: 1988 ident: 2023072910091668700_BIB22 publication-title: Methods Enzymol. doi: 10.1016/S0076-6879(88)65019-1 – volume: 16 start-page: 5501 year: 1997 ident: 2023072910091668700_BIB31 publication-title: EMBO J. doi: 10.1093/emboj/16.18.5501 – volume: 68 start-page: 221 year: 1990 ident: 2023072910091668700_BIB8 publication-title: Aeromonas salmonicida. Biochem. Cell Biol. doi: 10.1139/o90-029 – volume: 44 start-page: 987 year: 2004 ident: 2023072910091668700_BIB14 publication-title: Neuron. doi: 10.1016/j.neuron.2004.12.005 – volume: 19 start-page: 45 year: 2003 ident: 2023072910091668700_BIB9 publication-title: Annu. Rev. Cell Dev. Biol. doi: 10.1146/annurev.cellbio.19.111301.140655 – volume: 307 start-page: 1746 year: 2005 ident: 2023072910091668700_BIB29 publication-title: Science. doi: 10.1126/science.1105654 – volume: 265 start-page: 16644 year: 1990 ident: 2023072910091668700_BIB5 publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(17)46270-3 – volume: 98 start-page: 3180 year: 2001 ident: 2023072910091668700_BIB21 publication-title: Proc. Natl. Acad. Sci. USA. doi: 10.1073/pnas.051003498 |
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SubjectTerms | Amino Acid Sequence Animals Anthrax Antibodies Antigens, Bacterial - genetics Antigens, Bacterial - metabolism Bacterial Toxins - genetics Bacterial Toxins - metabolism Cell Line Cell membranes Cricetinae Endocytosis Endocytosis - physiology Enzymes Humans Lipids Membrane Microdomains - metabolism Membrane Proteins - chemistry Membrane Proteins - genetics Membrane Proteins - metabolism Molecular Sequence Data Neoplasm Proteins - chemistry Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Palmitic Acid - metabolism Peptides Physiological regulation Protein isoforms Protein Isoforms - chemistry Protein Isoforms - genetics Protein Isoforms - metabolism Protein Processing, Post-Translational Protein Subunits - genetics Protein Subunits - metabolism Proto-Oncogene Proteins c-cbl - genetics Proto-Oncogene Proteins c-cbl - metabolism Rafts Receptors Receptors, Cell Surface - chemistry Receptors, Cell Surface - genetics Receptors, Cell Surface - metabolism Receptors, Peptide RNA, Small Interfering - metabolism Sequence Alignment Toxins Ubiquitin - metabolism Western blotting |
Title | Receptor palmitoylation and ubiquitination regulate anthrax toxin endocytosis |
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