The distinguishing NS5-M114V mutation in American Zika virus isolates has negligible impacts on virus replication and transmission potential

• Published in: PLoS neglected tropical diseases Vol. 16; no. 5; p. e0010426
• Main Authors: Peng, Nias Y G, Amarilla, Alberto A, Hugo, Leon E, Modhiran, Naphak, Sng, Julian D J, Slonchak, Andrii, Watterson, Daniel, Setoh, Yin Xiang, Khromykh, Alexander A
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.05.2022; Public Library of Science (PLoS)
• Subjects: Amino acids; Analysis; Aquatic insects; Biological response modifiers; Biology and Life Sciences; Cells; Complications; Epidemics; Gene mutations; Genomes; Infections; Interferon; Medicine and Health Sciences; Methionine; Microbiological strains; Mosquitoes; Mutagenesis; Mutation; Neurological complications; NS5 protein; Nucleotide sequence; Outbreaks; People and Places; Proteins; Receptors; Replication; Saliva; Secretion; Stat2 protein; Strains; Transmission; Tropical diseases; Valine; Vector-borne diseases; Viremia; Virulence; Viruses; Zika virus; Australia; Asia; Pacific Islands

During 2015-2016, outbreaks of Zika virus (ZIKV) occurred in Southeast Asia and the Americas. Most ZIKV infections in humans are asymptomatic, while clinical manifestation is usually a self-limiting febrile disease with maculopapular rash. However, ZIKV is capable of inducing a range of severe neuro...