Epithelial IL-18 Equilibrium Controls Barrier Function in Colitis

• Published in: Cell Vol. 163; no. 6; pp. 1444 - 1456
• Main Authors: Nowarski, Roni, Jackson, Ruaidhrí, Gagliani, Nicola, de Zoete, Marcel R., Palm, Noah W., Bailis, Will, Low, Jun Siong, Harman, Christian C.D., Graham, Morven, Elinav, Eran, Flavell, Richard A.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 03.12.2015
• Subjects: Animals; Colitis, Ulcerative - chemically induced; Colitis, Ulcerative - metabolism; Colitis, Ulcerative - pathology; Colitis, Ulcerative - physiopathology; Dextran Sulfate; Endothelial Cells - metabolism; Epithelial Cells - cytology; epithelium; Female; Goblet Cells - metabolism; Goblet Cells - pathology; Intercellular Signaling Peptides and Proteins - genetics; Intercellular Signaling Peptides and Proteins - metabolism; interleukin-18; Interleukin-18 - immunology; Interleukin-18 Receptor alpha Subunit - genetics; Interleukin-18 Receptor alpha Subunit - metabolism; Intestinal Mucosa - physiopathology; intestines; Male; Mice; microbiome; mucus; Signal Transduction; transcription (genetics); ulcerative colitis

The intestinal mucosal barrier controlling the resident microbiome is dependent on a protective mucus layer generated by goblet cells, impairment of which is a hallmark of the inflammatory bowel disease, ulcerative colitis. Here, we show that IL-18 is critical in driving the pathologic breakdown of...