Epithelial IL-18 Equilibrium Controls Barrier Function in Colitis
The intestinal mucosal barrier controlling the resident microbiome is dependent on a protective mucus layer generated by goblet cells, impairment of which is a hallmark of the inflammatory bowel disease, ulcerative colitis. Here, we show that IL-18 is critical in driving the pathologic breakdown of...
Saved in:
| Published in | Cell Vol. 163; no. 6; pp. 1444 - 1456 |
|---|---|
| Main Authors | , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
03.12.2015
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | The intestinal mucosal barrier controlling the resident microbiome is dependent on a protective mucus layer generated by goblet cells, impairment of which is a hallmark of the inflammatory bowel disease, ulcerative colitis. Here, we show that IL-18 is critical in driving the pathologic breakdown of barrier integrity in a model of colitis. Deletion of Il18 or its receptor Il18r1 in intestinal epithelial cells (Δ/EC) conferred protection from colitis and mucosal damage in mice. In contrast, deletion of the IL-18 negative regulator Il18bp resulted in severe colitis associated with loss of mature goblet cells. Colitis and goblet cell loss were rescued in Il18bp−/−;Il18rΔ/EC mice, demonstrating that colitis severity is controlled at the level of IL-18 signaling in intestinal epithelial cells. IL-18 inhibited goblet cell maturation by regulating the transcriptional program instructing goblet cell development. These results inform on the mechanism of goblet cell dysfunction that underlies the pathology of ulcerative colitis.
[Display omitted]
•IL-18/IL-18R signaling in intestinal epithelial cells promotes DSS-induced colitis•Hyperactive epithelial IL-18 signaling drives goblet cell depletion during colitis•Epithelial IL-18 signaling prevents goblet cell maturation prior to colitis•IL-18 intercepts the transcriptional program controlling goblet cell development
Production of the cytokine IL-18 by epithelial cells, previously thought to protect the mucosal barrier from the effect of inflammation, is critical to drive the pathologic breakdown of intestinal barrier integrity, directly inhibiting goblet cell maturation prior to the onset of colitis. |
|---|---|
| AbstractList | The intestinal mucosal barrier controlling the resident microbiome is dependent on a protective mucus layer generated by goblet cells, impairment of which is a hallmark of the inflammatory bowel disease, ulcerative colitis. Here, we show that IL-18 is critical in driving the pathologic breakdown of barrier integrity in a model of colitis. Deletion of Il18 or its receptor Il18r1 in intestinal epithelial cells (Δ/EC) conferred protection from colitis and mucosal damage in mice. In contrast, deletion of the IL-18 negative regulator Il18bp resulted in severe colitis associated with loss of mature goblet cells. Colitis and goblet cell loss were rescued in Il18bp−/−;Il18rΔ/EC mice, demonstrating that colitis severity is controlled at the level of IL-18 signaling in intestinal epithelial cells. IL-18 inhibited goblet cell maturation by regulating the transcriptional program instructing goblet cell development. These results inform on the mechanism of goblet cell dysfunction that underlies the pathology of ulcerative colitis.
[Display omitted]
•IL-18/IL-18R signaling in intestinal epithelial cells promotes DSS-induced colitis•Hyperactive epithelial IL-18 signaling drives goblet cell depletion during colitis•Epithelial IL-18 signaling prevents goblet cell maturation prior to colitis•IL-18 intercepts the transcriptional program controlling goblet cell development
Production of the cytokine IL-18 by epithelial cells, previously thought to protect the mucosal barrier from the effect of inflammation, is critical to drive the pathologic breakdown of intestinal barrier integrity, directly inhibiting goblet cell maturation prior to the onset of colitis. The intestinal mucosal barrier controlling the resident microbiome is dependent on a protective mucus layer generated by goblet cells, impairment of which is a hallmark of the inflammatory bowel disease, ulcerative colitis. Here, we show that IL-18 is critical in driving the pathologic breakdown of barrier integrity in a model of colitis. Deletion of Il18 or its receptor Il18r1 in intestinal epithelial cells (Δ/EC) conferred protection from colitis and mucosal damage in mice. In contrast, deletion of the IL-18 negative regulator Il18bp resulted in severe colitis associated with loss of mature goblet cells. Colitis and goblet cell loss were rescued in Il18bp(-/-);Il18r(Δ/EC) mice, demonstrating that colitis severity is controlled at the level of IL-18 signaling in intestinal epithelial cells. IL-18 inhibited goblet cell maturation by regulating the transcriptional program instructing goblet cell development. These results inform on the mechanism of goblet cell dysfunction that underlies the pathology of ulcerative colitis.The intestinal mucosal barrier controlling the resident microbiome is dependent on a protective mucus layer generated by goblet cells, impairment of which is a hallmark of the inflammatory bowel disease, ulcerative colitis. Here, we show that IL-18 is critical in driving the pathologic breakdown of barrier integrity in a model of colitis. Deletion of Il18 or its receptor Il18r1 in intestinal epithelial cells (Δ/EC) conferred protection from colitis and mucosal damage in mice. In contrast, deletion of the IL-18 negative regulator Il18bp resulted in severe colitis associated with loss of mature goblet cells. Colitis and goblet cell loss were rescued in Il18bp(-/-);Il18r(Δ/EC) mice, demonstrating that colitis severity is controlled at the level of IL-18 signaling in intestinal epithelial cells. IL-18 inhibited goblet cell maturation by regulating the transcriptional program instructing goblet cell development. These results inform on the mechanism of goblet cell dysfunction that underlies the pathology of ulcerative colitis. The intestinal mucosal barrier controlling the resident microbiome is dependent on a protective mucus layer generated by goblet cells, impairment of which is a hallmark of the inflammatory bowel disease, ulcerative colitis. Here, we show that IL-18 is critical in driving the pathologic breakdown of barrier integrity in a model of colitis. Deletion of Il18 or its receptor Il18r1 in intestinal epithelial cells (Δ/EC) conferred protection from colitis and mucosal damage in mice. In contrast, deletion of the IL-18 negative regulator Il18bp resulted in severe colitis associated with loss of mature goblet cells. Colitis and goblet cell loss were rescued in Il18bp⁻/⁻;Il18rΔ/ᴱC mice, demonstrating that colitis severity is controlled at the level of IL-18 signaling in intestinal epithelial cells. IL-18 inhibited goblet cell maturation by regulating the transcriptional program instructing goblet cell development. These results inform on the mechanism of goblet cell dysfunction that underlies the pathology of ulcerative colitis. The intestinal mucosal barrier controlling the resident microbiome is dependent on a protective mucus layer generated by goblet cells, impairment of which is a hallmark of the inflammatory bowel disease Ulcerative Colitis. Here we show that IL-18 is critical in driving the pathologic breakdown of barrier integrity in a model of colitis. Deletion of Il18 or its receptor Il18r1 in intestinal epithelial cells ( Δ/EC ) conferred protection from colitis and mucosal damage in mice. In contrast, deletion of the IL-18 negative regulator Il18bp resulted in severe colitis associated with loss of mature goblet cells. Colitis and goblet cell loss were rescued in Il18bp −/− ; Il18r Δ/EC mice, demonstrating that colitis severity is controlled at the level of IL-18 signaling in intestinal epithelial cells. IL-18 inhibited goblet cell maturation by regulating the transcriptional program instructing goblet cell development. These results inform on the mechanism of goblet cell dysfunction which underlies the pathology of Ulcerative Colitis. The intestinal mucosal barrier controlling the resident microbiome is dependent on a protective mucus layer generated by goblet cells, impairment of which is a hallmark of the inflammatory bowel disease, ulcerative colitis. Here, we show that IL-18 is critical in driving the pathologic breakdown of barrier integrity in a model of colitis. Deletion of Il18 or its receptor Il18r1 in intestinal epithelial cells (Δ/EC) conferred protection from colitis and mucosal damage in mice. In contrast, deletion of the IL-18 negative regulator Il18bp resulted in severe colitis associated with loss of mature goblet cells. Colitis and goblet cell loss were rescued in Il18bp(-/-);Il18r(Δ/EC) mice, demonstrating that colitis severity is controlled at the level of IL-18 signaling in intestinal epithelial cells. IL-18 inhibited goblet cell maturation by regulating the transcriptional program instructing goblet cell development. These results inform on the mechanism of goblet cell dysfunction that underlies the pathology of ulcerative colitis. |
| Author | Elinav, Eran Jackson, Ruaidhrí Flavell, Richard A. Gagliani, Nicola Bailis, Will Nowarski, Roni Palm, Noah W. Low, Jun Siong Graham, Morven Harman, Christian C.D. de Zoete, Marcel R. |
| AuthorAffiliation | 2 Center for Cellular and Molecular Imaging, Yale School of Medicine, New Haven, CT, USA, 06520 1 Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA, 06520 4 Howard Hughes Medical Institute, Yale University, New Haven, CT, USA, 06520 3 Immunology Department, Weizmann Institute of Science, Rehovot, Israel, 76100 |
| AuthorAffiliation_xml | – name: 1 Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA, 06520 – name: 4 Howard Hughes Medical Institute, Yale University, New Haven, CT, USA, 06520 – name: 2 Center for Cellular and Molecular Imaging, Yale School of Medicine, New Haven, CT, USA, 06520 – name: 3 Immunology Department, Weizmann Institute of Science, Rehovot, Israel, 76100 |
| Author_xml | – sequence: 1 givenname: Roni surname: Nowarski fullname: Nowarski, Roni organization: Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA – sequence: 2 givenname: Ruaidhrí surname: Jackson fullname: Jackson, Ruaidhrí organization: Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA – sequence: 3 givenname: Nicola surname: Gagliani fullname: Gagliani, Nicola organization: Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA – sequence: 4 givenname: Marcel R. surname: de Zoete fullname: de Zoete, Marcel R. organization: Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA – sequence: 5 givenname: Noah W. surname: Palm fullname: Palm, Noah W. organization: Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA – sequence: 6 givenname: Will surname: Bailis fullname: Bailis, Will organization: Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA – sequence: 7 givenname: Jun Siong surname: Low fullname: Low, Jun Siong organization: Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA – sequence: 8 givenname: Christian C.D. surname: Harman fullname: Harman, Christian C.D. organization: Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA – sequence: 9 givenname: Morven surname: Graham fullname: Graham, Morven organization: Center for Cellular and Molecular Imaging, Yale School of Medicine, New Haven, CT 06520, USA – sequence: 10 givenname: Eran surname: Elinav fullname: Elinav, Eran organization: Immunology Department, Weizmann Institute of Science, Rehovot 76100, Israel – sequence: 11 givenname: Richard A. surname: Flavell fullname: Flavell, Richard A. email: richard.flavell@yale.edu organization: Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/26638073$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFUcFq3DAQFSUh2aT9gR6Kj714O5JlW4JSSJdNG1jIpT0LrTxuZtFaG8kO5O8rs0loe0hPAzPvvXm8d8FOhjAgY-85LDnw5tNu6dD7pQBe58USWvGGLTjotpS8FSdsAaBFqZpWnrOLlHYAoOq6PmPnomkqBW21YFfrA4136Mn64mZTclWs7yfytI007YtVGMYYfCq-2hgJY3E9DW6kMBQ05KOnkdJbdtpbn_Dd07xkP6_XP1bfy83tt5vV1aZ0dS3HsrcalQa1hS6b6PRWcY6ta7KTvu-hd5pXtukFWgQhodaWK9DW2UqgbJ2sLtmXo-5h2u6xc5itWW8OkfY2Pppgyfx9GejO_AoPRmpZgVBZ4OOTQAz3E6bR7CnNCdoBw5SMyPmIqq4B_gvlrWxUy7XQGfrhT1svfp4jzgB1BLgYUorYG0ejnUPMLskbDmZu0-zM_MDMbc673Gamin-oz-qvkj4fSZjLeMilmeQIB4cdRXSj6QK9Rv8Njz-3_Q |
| CitedBy_id | crossref_primary_10_1016_j_fct_2024_114830 crossref_primary_10_1016_j_immuni_2021_03_024 crossref_primary_10_1021_acs_jafc_0c07378 crossref_primary_10_1021_acsnano_3c11496 crossref_primary_10_1155_are_1839162 crossref_primary_10_1038_s41419_021_04420_1 crossref_primary_10_1093_cvr_cvz091 crossref_primary_10_1111_imr_12616 crossref_primary_10_1016_j_jff_2019_05_033 crossref_primary_10_1016_j_cell_2015_10_048 crossref_primary_10_1155_2016_9686238 crossref_primary_10_1016_j_rvsc_2024_105294 crossref_primary_10_1080_2162402X_2017_1313369 crossref_primary_10_1016_j_celrep_2022_111454 crossref_primary_10_1016_j_apsb_2021_03_011 crossref_primary_10_3389_fcell_2022_910983 crossref_primary_10_1084_jem_20212523 crossref_primary_10_1016_j_ijpharm_2022_121884 crossref_primary_10_1080_14728222_2022_2084381 crossref_primary_10_3389_fphar_2022_1033874 crossref_primary_10_1073_pnas_1515793113 crossref_primary_10_1097_ACI_0000000000000396 crossref_primary_10_7759_cureus_10812 crossref_primary_10_3389_fimmu_2022_919973 crossref_primary_10_1016_j_phrs_2022_106056 crossref_primary_10_1007_s11626_019_00401_z crossref_primary_10_1016_j_xphs_2024_03_001 crossref_primary_10_7554_eLife_10903 crossref_primary_10_1038_s41467_022_35256_8 crossref_primary_10_1007_s10753_018_0790_y crossref_primary_10_3389_fendo_2020_620466 crossref_primary_10_1093_femspd_ftw111 crossref_primary_10_1111_imr_12602 crossref_primary_10_1016_j_intimp_2021_108405 crossref_primary_10_1016_j_jcmgh_2022_03_007 crossref_primary_10_1136_gutjnl_2021_325792 crossref_primary_10_3390_foods10112711 crossref_primary_10_3389_fphar_2019_01466 crossref_primary_10_1080_15548627_2016_1184799 crossref_primary_10_1007_s13668_023_00458_z crossref_primary_10_3390_ijms20081912 crossref_primary_10_3389_fimmu_2021_758227 crossref_primary_10_3389_fimmu_2023_1106737 crossref_primary_10_1053_j_gastro_2017_11_276 crossref_primary_10_1038_s41392_019_0074_5 crossref_primary_10_1016_j_jaci_2016_10_022 crossref_primary_10_1097_WNR_0000000000002076 crossref_primary_10_3390_biomedicines11123229 crossref_primary_10_1016_j_bbii_2024_100046 crossref_primary_10_1371_journal_ppat_1011747 crossref_primary_10_1080_19490976_2024_2341457 crossref_primary_10_1186_s13073_024_01336_1 crossref_primary_10_1038_s41590_023_01450_z crossref_primary_10_3390_ijms25031858 crossref_primary_10_1016_j_celrep_2021_109043 crossref_primary_10_1093_ecco_jcc_jjy205 crossref_primary_10_1016_j_jff_2017_01_051 crossref_primary_10_1007_s00335_018_9783_2 crossref_primary_10_1038_s41467_018_06125_0 crossref_primary_10_3389_fphar_2022_822833 crossref_primary_10_1038_s41590_020_0681_x crossref_primary_10_1186_s12967_024_05673_y crossref_primary_10_1016_j_bbi_2020_11_004 crossref_primary_10_1155_2021_8030297 crossref_primary_10_3390_cells10051230 crossref_primary_10_1152_physrev_00018_2022 crossref_primary_10_1016_j_jff_2024_106394 crossref_primary_10_3389_fimmu_2020_01630 crossref_primary_10_1128_mbio_03338_23 crossref_primary_10_3389_fimmu_2021_658354 crossref_primary_10_1038_s41522_020_00143_x crossref_primary_10_3389_fimmu_2021_750841 crossref_primary_10_1007_s00253_023_12806_8 crossref_primary_10_3390_ijms22147613 crossref_primary_10_3389_fimmu_2022_841732 crossref_primary_10_3389_fimmu_2018_00072 crossref_primary_10_1146_annurev_immunol_051116_052424 crossref_primary_10_1016_j_jmb_2021_167278 crossref_primary_10_1016_j_cell_2015_11_041 crossref_primary_10_1146_annurev_immunol_042617_053055 crossref_primary_10_3389_fddsv_2022_1001487 crossref_primary_10_3389_fimmu_2021_749979 crossref_primary_10_1038_s41575_024_00931_2 crossref_primary_10_1053_j_gastro_2021_12_288 crossref_primary_10_1172_JCI126923 crossref_primary_10_1172_jci_insight_96322 crossref_primary_10_70813_ssd_1521172 crossref_primary_10_11569_wcjd_v27_i6_389 crossref_primary_10_3389_fphar_2024_1405503 crossref_primary_10_1007_s10753_019_01028_8 crossref_primary_10_5466_ijoms_21_60 crossref_primary_10_1126_scitranslmed_aaw0720 crossref_primary_10_1016_j_devcel_2022_05_013 crossref_primary_10_1002_bab_2451 crossref_primary_10_1016_j_scitotenv_2020_140533 crossref_primary_10_1111_cmi_13079 crossref_primary_10_3389_fimmu_2019_02538 crossref_primary_10_3390_ijms21217976 crossref_primary_10_3389_fimmu_2017_01131 crossref_primary_10_1016_j_immuni_2024_06_001 crossref_primary_10_2147_JIR_S470520 crossref_primary_10_1039_D3FO03654E crossref_primary_10_1007_s10620_024_08453_2 crossref_primary_10_1080_19490976_2022_2035661 crossref_primary_10_3389_fendo_2022_933110 crossref_primary_10_1002_ctm2_1449 crossref_primary_10_1111_cmi_13191 crossref_primary_10_1016_j_cyto_2021_155781 crossref_primary_10_3390_molecules26061725 crossref_primary_10_3389_fimmu_2019_00465 crossref_primary_10_1016_j_jcmgh_2022_05_006 crossref_primary_10_1146_annurev_physiol_042022_025619 crossref_primary_10_11569_wcjd_v30_i21_928 crossref_primary_10_3389_fimmu_2017_01020 crossref_primary_10_1038_nri_2016_88 crossref_primary_10_1016_j_apsb_2024_11_019 crossref_primary_10_1007_s11481_021_10050_3 crossref_primary_10_3390_biomedicines9020134 crossref_primary_10_1016_j_celrep_2023_112410 crossref_primary_10_4110_in_2024_24_e1 crossref_primary_10_1002_eji_202250354 crossref_primary_10_1038_s41420_022_00998_3 crossref_primary_10_1016_j_rvsc_2022_09_021 crossref_primary_10_1128_spectrum_01784_23 crossref_primary_10_1016_j_autrev_2020_102617 crossref_primary_10_1080_14728222_2019_1696309 crossref_primary_10_1016_j_molmed_2018_01_004 crossref_primary_10_1039_D0FO02556A crossref_primary_10_3390_medicina59111990 crossref_primary_10_3748_wjg_v29_i15_2283 crossref_primary_10_1016_j_ecoenv_2023_115154 crossref_primary_10_1080_17474124_2019_1671822 crossref_primary_10_1021_acs_jafc_9b07988 crossref_primary_10_1039_D1FO00410G crossref_primary_10_1038_s41598_020_75675_5 crossref_primary_10_3389_fmicb_2023_1298304 crossref_primary_10_1097_SHK_0000000000001462 crossref_primary_10_1016_j_celrep_2019_10_042 crossref_primary_10_1038_s41392_022_01046_3 crossref_primary_10_1158_0008_5472_CAN_16_2346 crossref_primary_10_1002_ctm2_993 crossref_primary_10_1007_s00281_021_00854_z crossref_primary_10_1016_j_cellsig_2019_109388 crossref_primary_10_1016_j_mucimm_2024_05_001 crossref_primary_10_3389_fimmu_2018_02566 crossref_primary_10_1038_ncomms15004 crossref_primary_10_1038_s41422_023_00790_7 crossref_primary_10_3389_fgstr_2022_914371 crossref_primary_10_1126_sciadv_aaz6717 crossref_primary_10_1155_2020_4063562 crossref_primary_10_3390_molecules26164996 crossref_primary_10_1093_ibd_izaa232 crossref_primary_10_1038_s41575_022_00698_4 crossref_primary_10_1007_s12602_020_09694_z crossref_primary_10_1007_s11130_019_00736_8 crossref_primary_10_3390_ijerph182312836 crossref_primary_10_1016_j_bbrc_2019_04_136 crossref_primary_10_1155_2021_6682233 crossref_primary_10_3389_fcell_2024_1258859 crossref_primary_10_1016_j_bbagrm_2018_01_020 crossref_primary_10_3390_ani13152519 crossref_primary_10_4166_kjg_2019_73_5_311 crossref_primary_10_1016_j_intimp_2024_112281 crossref_primary_10_1038_nature17039 crossref_primary_10_1016_j_gpb_2016_12_003 crossref_primary_10_1053_j_gastro_2021_03_050 crossref_primary_10_1038_s41392_021_00535_1 crossref_primary_10_1073_pnas_1700909114 crossref_primary_10_1016_j_fbio_2023_103527 crossref_primary_10_1038_nrd_2018_97 crossref_primary_10_1007_s00204_020_02801_7 crossref_primary_10_1038_s41575_018_0054_1 crossref_primary_10_1080_10520295_2023_2224061 crossref_primary_10_1186_s40425_018_0408_9 crossref_primary_10_1038_s41586_018_0794_7 crossref_primary_10_1038_s41422_023_00891_3 crossref_primary_10_1128_microbiolspec_BAD_0019_2017 crossref_primary_10_1016_j_cell_2024_03_013 crossref_primary_10_1136_gutjnl_2015_310847 crossref_primary_10_3390_microorganisms8101587 crossref_primary_10_1016_j_intimp_2020_107194 crossref_primary_10_3389_fphar_2022_833588 crossref_primary_10_1172_JCI123263 crossref_primary_10_2147_JIR_S318327 crossref_primary_10_3892_mmr_2022_12765 crossref_primary_10_1038_s41467_023_39487_1 crossref_primary_10_1016_j_smim_2016_10_001 crossref_primary_10_3390_cells10020348 crossref_primary_10_1038_s41590_020_0697_2 crossref_primary_10_3389_fcell_2021_725821 crossref_primary_10_3389_fvets_2023_1183400 crossref_primary_10_1007_s12079_019_00544_4 crossref_primary_10_1016_j_jmb_2017_03_031 crossref_primary_10_1155_2016_9765238 crossref_primary_10_1038_s41598_018_20632_6 crossref_primary_10_1097_BOR_0000000000000634 crossref_primary_10_1080_19490976_2024_2413372 crossref_primary_10_17116_dokgastro20221101128 crossref_primary_10_1016_j_micinf_2016_03_008 crossref_primary_10_3748_wjg_v23_i33_6137 crossref_primary_10_1038_ni_3384 crossref_primary_10_1016_j_cyto_2022_155890 crossref_primary_10_1007_s00018_017_2509_x crossref_primary_10_1016_j_fbio_2024_104384 crossref_primary_10_1111_cts_13442 crossref_primary_10_3389_fimmu_2020_609400 crossref_primary_10_1155_2021_2617881 crossref_primary_10_1038_s41575_020_0326_4 crossref_primary_10_1002_eji_201545957 crossref_primary_10_1038_s41575_018_0079_5 crossref_primary_10_1016_j_biopha_2023_115587 crossref_primary_10_1016_j_biomaterials_2018_07_044 crossref_primary_10_1016_j_celrep_2019_03_028 crossref_primary_10_3389_fmed_2024_1396789 crossref_primary_10_3390_ph15091080 crossref_primary_10_1038_nrgastro_2015_217 crossref_primary_10_1084_jem_20160462 crossref_primary_10_1007_s00281_019_00732_9 crossref_primary_10_1016_j_cyto_2017_04_002 crossref_primary_10_3390_ijms20071689 crossref_primary_10_1016_j_cej_2021_130464 crossref_primary_10_3390_cancers13143620 crossref_primary_10_1038_s41467_020_18420_w crossref_primary_10_3390_antiox11122404 crossref_primary_10_3389_fgene_2020_00645 crossref_primary_10_1016_j_autrev_2019_03_006 crossref_primary_10_1038_s41577_024_01008_6 crossref_primary_10_1038_s41581_019_0118_7 crossref_primary_10_1038_s42003_023_04810_5 crossref_primary_10_18632_oncotarget_8867 crossref_primary_10_3390_ijms222413642 crossref_primary_10_3389_fimmu_2023_1254150 crossref_primary_10_1038_s41419_019_1413_8 crossref_primary_10_1089_jir_2019_0011 crossref_primary_10_1016_j_ijbiomac_2024_133665 crossref_primary_10_1002_eji_201848056 crossref_primary_10_1097_IM9_0000000000000047 crossref_primary_10_1093_ecco_jcc_jjab222 crossref_primary_10_1038_s41435_024_00253_y crossref_primary_10_1016_j_molmed_2016_02_008 crossref_primary_10_1139_apnm_2017_0689 crossref_primary_10_3389_fimmu_2018_02918 crossref_primary_10_1371_journal_pntd_0010029 crossref_primary_10_3389_fimmu_2022_855645 crossref_primary_10_1016_j_celrep_2017_05_009 crossref_primary_10_4049_jimmunol_2300518 crossref_primary_10_1016_j_cell_2019_12_016 crossref_primary_10_1158_2326_6066_CIR_16_0269 crossref_primary_10_1371_journal_pone_0194185 crossref_primary_10_3389_fimmu_2023_1165667 crossref_primary_10_1371_journal_pntd_0004944 crossref_primary_10_1084_jem_20171419 crossref_primary_10_1016_j_ijbiomac_2023_123323 crossref_primary_10_3389_fphar_2021_766474 crossref_primary_10_1038_s41385_022_00506_x crossref_primary_10_1080_17435390_2023_2289940 crossref_primary_10_3390_cells10010111 crossref_primary_10_1038_s41586_022_05111_3 crossref_primary_10_1016_j_jep_2020_113243 crossref_primary_10_3389_fimmu_2023_1272639 crossref_primary_10_1038_s41467_019_11944_w crossref_primary_10_1371_journal_pone_0230231 crossref_primary_10_1186_s12929_023_00983_7 crossref_primary_10_1016_j_cell_2019_12_021 crossref_primary_10_1016_j_snb_2024_135516 crossref_primary_10_1038_s41385_020_0296_4 crossref_primary_10_3390_microorganisms9030622 crossref_primary_10_1038_s41584_023_01053_w crossref_primary_10_1126_sciadv_abq1551 crossref_primary_10_1016_j_ecoenv_2024_116458 crossref_primary_10_3389_fimmu_2023_1154552 crossref_primary_10_1038_nrc_2017_13 crossref_primary_10_1021_acs_jafc_3c06421 crossref_primary_10_3389_fimmu_2019_01266 crossref_primary_10_3390_biomedicines10010083 crossref_primary_10_1002_advs_202500116 crossref_primary_10_1155_2023_1535484 crossref_primary_10_1182_blood_2017_12_820852 crossref_primary_10_1097_ICO_0000000000001717 crossref_primary_10_1038_s41385_018_0058_8 crossref_primary_10_1084_jem_20181210 crossref_primary_10_1097_MOG_0000000000000315 crossref_primary_10_3390_ijms241310976 crossref_primary_10_1152_ajpgi_00244_2022 crossref_primary_10_1016_j_tins_2022_10_002 crossref_primary_10_3390_nu14061148 crossref_primary_10_1007_s12028_020_01113_z crossref_primary_10_1007_s11356_021_15575_x crossref_primary_10_1007_s00018_021_03812_y crossref_primary_10_3389_fimmu_2017_01168 crossref_primary_10_1172_JCI138103 crossref_primary_10_1038_s41388_019_0777_7 crossref_primary_10_3390_nu15061394 crossref_primary_10_1038_s41392_021_00507_5 crossref_primary_10_3390_cancers12123500 crossref_primary_10_1136_gutjnl_2019_319523 crossref_primary_10_1016_j_immuni_2019_03_012 crossref_primary_10_3389_fphar_2024_1446486 crossref_primary_10_3389_fimmu_2023_1126823 crossref_primary_10_1016_j_immuni_2019_03_017 crossref_primary_10_1016_j_it_2018_04_002 crossref_primary_10_1007_s11427_022_2213_6 crossref_primary_10_3390_cells12212538 crossref_primary_10_3390_ijms21218145 crossref_primary_10_3390_jcm13206058 crossref_primary_10_1016_j_celrep_2018_07_066 crossref_primary_10_1042_CS20181081 crossref_primary_10_3390_ijms23031651 crossref_primary_10_1007_s00384_024_04744_2 crossref_primary_10_3390_pathogens11020160 crossref_primary_10_3389_fendo_2022_971745 crossref_primary_10_15252_emmm_202013452 crossref_primary_10_1016_j_lssr_2024_03_003 crossref_primary_10_3390_antiox10121954 crossref_primary_10_1016_j_celrep_2017_05_058 crossref_primary_10_3389_fimmu_2021_772189 crossref_primary_10_2177_jsci_39_522 crossref_primary_10_1016_j_taap_2023_116494 crossref_primary_10_1111_jcmm_18348 crossref_primary_10_1111_febs_16888 crossref_primary_10_1267_ahc_24_00049 crossref_primary_10_1038_s41590_019_0415_0 crossref_primary_10_3389_fimmu_2022_952639 crossref_primary_10_1002_bies_201800027 crossref_primary_10_18632_aging_205091 crossref_primary_10_3390_biomedicines12122771 crossref_primary_10_1371_journal_pntd_0009171 crossref_primary_10_1016_j_lfs_2017_08_010 crossref_primary_10_1038_s41568_019_0123_y crossref_primary_10_1073_pnas_2009217118 crossref_primary_10_3390_nu16071070 crossref_primary_10_3389_fcell_2023_1213383 crossref_primary_10_1038_s41385_022_00494_y crossref_primary_10_1007_s00394_022_03064_x crossref_primary_10_1016_j_ijbiomac_2023_123862 crossref_primary_10_3389_fgstr_2022_1022530 crossref_primary_10_1016_j_cyto_2023_156413 crossref_primary_10_1126_sciadv_abg0470 crossref_primary_10_1038_s41419_019_1580_7 crossref_primary_10_3390_ijms252413505 crossref_primary_10_1128_Spectrum_00730_21 crossref_primary_10_1083_jcb_201602089 crossref_primary_10_1096_fj_201700034R crossref_primary_10_3389_fcimb_2021_806680 crossref_primary_10_3390_ijms221910851 crossref_primary_10_1016_j_phymed_2022_154452 crossref_primary_10_1016_j_lfs_2023_121868 crossref_primary_10_1002_mnfr_202200253 crossref_primary_10_52711_0974_360X_2022_00313 crossref_primary_10_7554_eLife_65762 crossref_primary_10_1016_j_bcp_2018_07_039 crossref_primary_10_3389_fimmu_2019_00805 crossref_primary_10_1016_j_celrep_2017_04_046 crossref_primary_10_3390_antiox13091107 crossref_primary_10_1038_s41598_018_32366_6 crossref_primary_10_1093_ecco_jcc_jjy035 crossref_primary_10_3389_fimmu_2021_777665 crossref_primary_10_1002_JLB_3RU0322_176R crossref_primary_10_1038_s41385_019_0177_x crossref_primary_10_1097_CM9_0000000000003389 crossref_primary_10_1038_s41385_022_00547_2 crossref_primary_10_1002_lt_25709 crossref_primary_10_1038_s41586_020_2729_3 crossref_primary_10_1136_gutjnl_2020_321094 crossref_primary_10_3390_ijms25021311 crossref_primary_10_1038_s41598_022_18771_y crossref_primary_10_3390_cancers12123550 crossref_primary_10_1016_j_intimp_2022_109020 crossref_primary_10_3390_molecules26227002 crossref_primary_10_1007_s10048_024_00779_3 crossref_primary_10_1186_s43556_024_00207_w crossref_primary_10_1093_ibd_izad292 crossref_primary_10_1016_j_cell_2016_11_040 crossref_primary_10_1016_j_fct_2018_12_015 crossref_primary_10_1002_eji_202451053 crossref_primary_10_1111_febs_16449 crossref_primary_10_1172_jci_insight_150607 crossref_primary_10_1165_rcmb_2016_0404OC crossref_primary_10_1016_j_actbio_2022_02_039 crossref_primary_10_1016_j_ijpara_2019_12_011 crossref_primary_10_1002_eji_202048876 crossref_primary_10_1039_D4FO00741G crossref_primary_10_1038_s41467_022_28478_3 crossref_primary_10_3389_fmicb_2025_1556953 crossref_primary_10_1016_j_immuni_2018_08_024 crossref_primary_10_2174_0113894501255960231101105113 crossref_primary_10_3390_ijms23031105 crossref_primary_10_1038_s41467_024_54174_5 crossref_primary_10_1016_j_intimp_2023_111414 crossref_primary_10_1146_annurev_immunol_051116_052133 crossref_primary_10_1093_hmg_ddz155 crossref_primary_10_1097_CCO_0000000000000346 crossref_primary_10_4110_in_2019_19_e28 crossref_primary_10_1016_j_chom_2016_03_003 crossref_primary_10_15252_embr_202154453 crossref_primary_10_3390_ijms26052237 crossref_primary_10_1111_imm_12989 crossref_primary_10_1016_j_foodres_2024_115383 crossref_primary_10_1016_j_micinf_2024_105398 crossref_primary_10_1038_s41583_021_00555_4 crossref_primary_10_1016_j_advnut_2024_100307 crossref_primary_10_1016_j_mucimm_2024_02_008 crossref_primary_10_1038_s41385_021_00419_1 crossref_primary_10_3389_fimmu_2019_01091 crossref_primary_10_3389_fimmu_2023_1086898 crossref_primary_10_1016_j_lfs_2019_116593 crossref_primary_10_1038_s41598_019_45747_2 crossref_primary_10_1093_ibd_izae042 crossref_primary_10_1136_gutjnl_2018_317571 crossref_primary_10_1016_j_stemcr_2021_10_011 crossref_primary_10_1016_j_omto_2023_08_007 crossref_primary_10_1111_nyas_13280 crossref_primary_10_1080_19490976_2017_1421888 crossref_primary_10_1093_gastro_goad068 crossref_primary_10_1111_1751_2980_12704 crossref_primary_10_1016_j_cell_2018_08_063 crossref_primary_10_1371_journal_pone_0171703 crossref_primary_10_1007_s11427_020_1720_9 crossref_primary_10_1016_j_molimm_2023_07_012 crossref_primary_10_3390_ijms25158437 crossref_primary_10_1073_pnas_2024853118 |
| Cites_doi | 10.1038/35079107 10.4049/jimmunol.163.1.143 10.1111/j.1742-1241.2007.01665.x 10.1053/gast.2001.29579 10.1016/j.diff.2008.09.008 10.1126/science.1065718 10.1074/jbc.273.45.29445 10.1038/71657 10.1038/nm1415 10.1038/nature06005 10.4049/jimmunol.162.11.6829 10.1038/nri2891 10.4049/jimmunol.162.9.5041 10.1084/jem.20100199 10.1093/intimm/dxu066 10.1016/j.cell.2013.04.025 10.1038/nature12599 10.1097/00042737-200306000-00008 10.1038/nature10809 10.1038/nrg1607 10.1152/ajpregu.2001.281.4.R1264 10.1136/gut.50.6.812 10.1136/gut.2006.118646 10.1016/j.immuni.2010.03.010 10.1056/NEJMra1102942 10.1038/nature10208 10.1172/JCI7501 10.1136/jcp.43.2.143 10.4049/jimmunol.0901363 10.1016/S1074-7613(00)80543-9 10.1016/j.immuni.2010.02.012 10.1128/IAI.00093-07 10.1038/nature03659 10.1053/gast.2001.28021 10.1084/jem.20101330 10.1016/j.cyto.2012.06.014 10.1016/j.molmed.2015.06.003 10.1016/S1074-7613(00)80013-8 10.1053/j.gastro.2009.06.044 10.1242/dev.129.11.2619 10.1146/annurev-immunol-030409-101225 10.1101/gad.1353905 10.1136/gutjnl-2012-303329 10.1016/S1097-2765(00)80136-7 10.1016/j.immuni.2010.03.003 10.3389/fimmu.2013.00181 10.1126/science.278.5339.860 10.1016/j.cell.2011.04.022 10.1038/ni.1960 10.1016/j.cell.2015.10.048 10.1016/j.cell.2014.11.037 10.1007/s004410050895 10.1016/S1097-2765(02)00599-3 10.1097/MOG.0b013e328136c580 10.1016/S1074-7613(00)80596-8 10.1136/gut.35.3.353 10.1016/j.yexcr.2009.09.020 10.3389/fimmu.2013.00289 10.1038/35079114 10.1038/nri3661 10.1038/nature07416 10.4049/jimmunol.1400501 10.1038/nprot.2006.446 10.1128/iai.57.2.590-595.1989 10.1007/s00018-011-0827-y 10.1038/mi.2011.65 10.1189/jlb.0503230 10.1080/00365520310004047 10.1038/nature03589 |
| ContentType | Journal Article |
| Copyright | 2015 Elsevier Inc. Copyright © 2015 Elsevier Inc. All rights reserved. |
| Copyright_xml | – notice: 2015 Elsevier Inc. – notice: Copyright © 2015 Elsevier Inc. All rights reserved. |
| DBID | 6I. AAFTH AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 7S9 L.6 5PM |
| DOI | 10.1016/j.cell.2015.10.072 |
| DatabaseName | ScienceDirect Open Access Titles Elsevier:ScienceDirect:Open Access CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic AGRICOLA AGRICOLA - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic AGRICOLA AGRICOLA - Academic |
| DatabaseTitleList | MEDLINE - Academic AGRICOLA MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology |
| EISSN | 1097-4172 |
| EndPage | 1456 |
| ExternalDocumentID | PMC4943028 26638073 10_1016_j_cell_2015_10_072 S0092867415014282 |
| Genre | Research Support, Non-U.S. Gov't Journal Article |
| GrantInformation_xml | – fundername: NIDDK NIH HHS grantid: P30 DK045735 – fundername: Howard Hughes Medical Institute – fundername: NIDDK NIH HHS grantid: P30 DK034989 |
| GroupedDBID | --- --K -DZ -ET -~X 0R~ 0WA 1RT 1~5 29B 2FS 2WC 3EH 4.4 457 4G. 53G 5GY 5RE 62- 6I. 6J9 7-5 85S AACTN AAEDT AAEDW AAFTH AAFWJ AAIAV AAKRW AAKUH AAUCE AAVLU AAXJY AAXUO AAYJJ ABCQX ABJNI ABMAC ABMWF ABOCM ABVKL ACGFO ACGFS ACNCT ADBBV ADEZE ADJPV AEFWE AENEX AEXQZ AFTJW AGHFR AGHSJ AGKMS AHHHB AIDAL AITUG ALKID ALMA_UNASSIGNED_HOLDINGS AMRAJ ASPBG AVWKF AZFZN BAWUL CS3 DIK DU5 E3Z EBS EJD F5P FCP FDB FIRID HH5 IH2 IHE IXB J1W JIG K-O KOO KQ8 L7B LX5 M3Z M41 N9A NCXOZ O-L O9- OK1 P2P RCE RIG RNS ROL RPZ SCP SDG SDP SES SSZ TAE TN5 TR2 TWZ UKR UPT VQA WH7 WQ6 YZZ ZA5 ZCA .-4 .55 .GJ .HR 1CY 1VV 2KS 3O- 5VS 6TJ 9M8 AAHBH AAIKJ AALRI AAMRU AAQFI AAQXK AAYWO AAYXX ABDGV ABDPE ABEFU ABWVN ACRPL ACVFH ADCNI ADMUD ADNMO ADVLN ADXHL AETEA AEUPX AFPUW AGCQF AGQPQ AI. AIGII AKAPO AKBMS AKRWK AKYEP APXCP CITATION FEDTE FGOYB G-2 HVGLF HZ~ H~9 MVM OHT OMK OZT PUQ R2- UBW UHB VH1 X7M YYP YYQ ZGI ZHY ZKB ZY4 0SF CGR CUY CVF ECM EIF NPM 7X8 7S9 L.6 5PM EFKBS |
| ID | FETCH-LOGICAL-c554t-fa9e8908b0d855d9b811e7c6663fff0fc913a6f2eae024059a1809aca32e47c43 |
| IEDL.DBID | IXB |
| ISSN | 0092-8674 1097-4172 |
| IngestDate | Thu Aug 21 18:16:47 EDT 2025 Thu Jul 10 21:36:18 EDT 2025 Fri Jul 11 07:01:24 EDT 2025 Thu Jan 02 23:09:39 EST 2025 Tue Jul 01 02:16:54 EDT 2025 Thu Apr 24 23:01:10 EDT 2025 Fri Feb 23 02:30:33 EST 2024 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 6 |
| Language | English |
| License | http://www.elsevier.com/open-access/userlicense/1.0 Copyright © 2015 Elsevier Inc. All rights reserved. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c554t-fa9e8908b0d855d9b811e7c6663fff0fc913a6f2eae024059a1809aca32e47c43 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Co-first authors |
| OpenAccessLink | https://www.sciencedirect.com/science/article/pii/S0092867415014282 |
| PMID | 26638073 |
| PQID | 1746871929 |
| PQPubID | 23479 |
| PageCount | 13 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_4943028 proquest_miscellaneous_2000235500 proquest_miscellaneous_1746871929 pubmed_primary_26638073 crossref_citationtrail_10_1016_j_cell_2015_10_072 crossref_primary_10_1016_j_cell_2015_10_072 elsevier_sciencedirect_doi_10_1016_j_cell_2015_10_072 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2015-12-03 |
| PublicationDateYYYYMMDD | 2015-12-03 |
| PublicationDate_xml | – month: 12 year: 2015 text: 2015-12-03 day: 03 |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | Cell |
| PublicationTitleAlternate | Cell |
| PublicationYear | 2015 |
| Publisher | Elsevier Inc |
| Publisher_xml | – name: Elsevier Inc |
| References | Born, Thomassen, Bird, Sims (bib9) 1998; 273 Adachi, Kawai, Takeda, Matsumoto, Tsutsui, Sakagami, Nakanishi, Akira (bib1) 1998; 9 Siegmund (bib56) 2010; 32 Fantuzzi, Banda, Guthridge, Vondracek, Kim, Siegmund, Azam, Sennello, Dinarello, Arend (bib16) 2003; 74 Fantuzzi, Reed, Dinarello (bib15) 1999; 104 Mercurio, Zhu, Murray, Shevchenko, Bennett, Li, Young, Barbosa, Mann, Manning, Rao (bib38) 1997; 278 Dupaul-Chicoine, Yeretssian, Doiron, Bergstrom, McIntire, LeBlanc, Meunier, Turbide, Gros, Beauchemin (bib13) 2010; 32 Kanai, Watanabe, Okazawa, Sato, Yamazaki, Okamoto, Ishii, Totsuka, Iiyama, Okamoto (bib26) 2001; 121 Fre, Huyghe, Mourikis, Robine, Louvard, Artavanis-Tsakonas (bib18) 2005; 435 Fellermann, Wehkamp, Herrlinger, Stange (bib17) 2003; 15 Katz, Perreault, Goldstein, Lee, Labosky, Yang, Kaestner (bib29) 2002; 129 Levy, Thaiss, Zeevi, Dohnalová, Zilberman-Schapira, Ali Mahdi, David, Savidor, Korem, Herzig (bib30) 2015; 163 Wang, Yang, Shivalila, Dawlaty, Cheng, Zhang, Jaenisch (bib66) 2013; 153 Malvin, Seno, Stappenbeck (bib33) 2012; 5 Netea, Joosten, Lewis, Jensen, Voshol, Kullberg, Tack, van Krieken, Kim, Stalenhoef (bib42) 2006; 12 Bamias, Corridoni, Pizarro, Cominelli (bib4) 2012; 59 Ten Hove, Corbaz, Amitai, Aloni, Belzer, Graber, Drillenburg, van Deventer, Chvatchko, Te Velde (bib63) 2001; 121 Miao, Leaf, Treuting, Mao, Dors, Sarkar, Warren, Wewers, Aderem (bib39) 2010; 11 Rongvaux, Jackson, Harman, Li, West, de Zoete, Wu, Yordy, Lakhani, Kuan (bib51) 2014; 159 Salcedo, Worschech, Cardone, Jones, Gyulai, Dai, Wang, Ma, Haines, O’hUigin (bib52) 2010; 207 Henao-Mejia, Elinav, Jin, Hao, Mehal, Strowig, Thaiss, Kau, Eisenbarth, Jurczak (bib22) 2012; 482 Asquith, Powrie (bib3) 2010; 207 Medzhitov, Preston-Hurlburt, Kopp, Stadlen, Chen, Ghosh, Janeway (bib37) 1998; 2 Lopetuso, Chowdhry, Pizarro (bib31) 2013; 4 Becker, Fantini, Neurath (bib6) 2006; 1 Danese, Fiocchi (bib11) 2011; 365 Takeuchi, Nishizaki, Sano, Ohta, Ikeda, Kurimoto (bib62) 1997; 289 Yang, Bermingham, Finegold, Zoghbi (bib69) 2001; 294 Nuding, Fellermann, Wehkamp, Stange (bib46) 2007; 56 Siegmund, Fantuzzi, Rieder, Gamboni-Robertson, Lehr, Hartmann, Dinarello, Endres, Eigler (bib57) 2001; 281 Sivakumar, Westrich, Kanaly, Garka, Born, Derry, Viney (bib58) 2002; 50 Kaser, Zeissig, Blumberg (bib27) 2010; 28 Takeda, Tsutsui, Yoshimoto, Adachi, Yoshida, Kishimoto, Okamura, Nakanishi, Akira (bib61) 1998; 8 Trabucchi, Mukenge, Baratti, Colombo, Fregoni, Montorsi (bib64) 1986; 8 Schreiber, Rosenstiel, Albrecht, Hampe, Krawczak (bib54) 2005; 6 Martinon, Burns, Tschopp (bib34) 2002; 10 Elinav, Strowig, Kau, Henao-Mejia, Thaiss, Booth, Peaper, Bertin, Eisenbarth, Gordon, Flavell (bib14) 2011; 145 Hoshino, Tsutsui, Kawai, Takeda, Nakanishi, Takeda, Akira (bib23) 1999; 162 McCauley, Guasch (bib35) 2015; 21 McCormick, Horton, Mee (bib36) 1990; 43 Novick, Kim, Fantuzzi, Reznikov, Dinarello, Rubinstein (bib45) 1999; 10 Takagi, Kanai, Okazawa, Kishi, Sato, Takaishi, Inoue, Ogata, Iwao, Hoshino (bib60) 2003; 38 Bersudsky, Luski, Fishman, White, Ziv-Sokolovskaya, Dotan, Rider, Kaplanov, Aychek, Dinarello (bib8) 2014; 63 Gersemann, Becker, Kübler, Koslowski, Wang, Herrlinger, Griger, Fritz, Fellermann, Schwab (bib20) 2009; 77 Hugot, Chamaillard, Zouali, Lesage, Cézard, Belaiche, Almer, Tysk, O’Morain, Gassull (bib24) 2001; 411 Oficjalska, Raverdeau, Aviello, Wade, Hickey, Sheehan, Corr, Kay, O’Neill, Mills, Creagh (bib47) 2015; 194 Wehkamp, Schmid, Stange (bib67) 2007; 23 Gagliani, Palm, de Zoete, Flavell (bib19) 2014; 26 Strugala, Dettmar, Pearson (bib59) 2008; 62 Saleh, Trinchieri (bib53) 2011; 11 Shroyer, Wallis, Venken, Bellen, Zoghbi (bib55) 2005; 19 Noah, Kazanjian, Whitsett, Shroyer (bib44) 2010; 316 Ogura, Bonen, Inohara, Nicolae, Chen, Ramos, Britton, Moran, Karaliuskas, Duerr (bib48) 2001; 411 Dinarello, Novick, Kim, Kaplanski (bib12) 2013; 4 Nakamura, Okamura, Wada, Nagata, Tamura (bib41) 1989; 57 Gregorieff, Stange, Kujala, Begthel, van den Born, Korving, Peters, Clevers (bib21) 2009; 137 Cadwell, Liu, Brown, Miyoshi, Loh, Lennerz, Kishi, Kc, Carrero, Hunt (bib10) 2008; 456 Pullan, Thomas, Rhodes, Newcombe, Williams, Allen, Rhodes (bib50) 1994; 35 Kaser, Niederreiter, Blumberg (bib28) 2011; 68 Adolph, Tomczak, Niederreiter, Ko, Böck, Martinez-Naves, Glickman, Tschurtschenthaler, Hartwig, Hosomi (bib2) 2013; 503 Neurath (bib43) 2014; 14 Pizarro, Michie, Bentz, Woraratanadharm, Smith, Foley, Moskaluk, Bickston, Cominelli (bib49) 1999; 162 van Es, van Gijn, Riccio, van den Born, Vooijs, Begthel, Cozijnsen, Robine, Winton, Radtke, Clevers (bib65) 2005; 435 Bauernfeind, Horvath, Stutz, Alnemri, MacDonald, Speert, Fernandes-Alnemri, Wu, Monks, Fitzgerald (bib5) 2009; 183 Xavier, Podolsky (bib68) 2007; 448 Zaki, Boyd, Vogel, Kastan, Lamkanfi, Kanneganti (bib70) 2010; 32 Bergstrom, Guttman, Rumi, Ma, Bouzari, Khan, Gibson, Vogl, Vallance (bib7) 2008; 76 Jensen, Pedersen, Galante, Hald, Heller, Ishibashi, Kageyama, Guillemot, Serup, Madsen (bib25) 2000; 24 Monteleone, Trapasso, Parrello, Biancone, Stella, Iuliano, Luzza, Fusco, Pallone (bib40) 1999; 163 Maloy, Powrie (bib32) 2011; 474 Adachi (10.1016/j.cell.2015.10.072_bib1) 1998; 9 Zaki (10.1016/j.cell.2015.10.072_bib70) 2010; 32 Kaser (10.1016/j.cell.2015.10.072_bib27) 2010; 28 Martinon (10.1016/j.cell.2015.10.072_bib34) 2002; 10 Pullan (10.1016/j.cell.2015.10.072_bib50) 1994; 35 van Es (10.1016/j.cell.2015.10.072_bib65) 2005; 435 Bersudsky (10.1016/j.cell.2015.10.072_bib8) 2014; 63 Takeuchi (10.1016/j.cell.2015.10.072_bib62) 1997; 289 Trabucchi (10.1016/j.cell.2015.10.072_bib64) 1986; 8 Malvin (10.1016/j.cell.2015.10.072_bib33) 2012; 5 Siegmund (10.1016/j.cell.2015.10.072_bib56) 2010; 32 Rongvaux (10.1016/j.cell.2015.10.072_bib51) 2014; 159 Xavier (10.1016/j.cell.2015.10.072_bib68) 2007; 448 Jensen (10.1016/j.cell.2015.10.072_bib25) 2000; 24 Dupaul-Chicoine (10.1016/j.cell.2015.10.072_bib13) 2010; 32 Fellermann (10.1016/j.cell.2015.10.072_bib17) 2003; 15 Hugot (10.1016/j.cell.2015.10.072_bib24) 2001; 411 Kanai (10.1016/j.cell.2015.10.072_bib26) 2001; 121 Yang (10.1016/j.cell.2015.10.072_bib69) 2001; 294 Schreiber (10.1016/j.cell.2015.10.072_bib54) 2005; 6 Shroyer (10.1016/j.cell.2015.10.072_bib55) 2005; 19 Fantuzzi (10.1016/j.cell.2015.10.072_bib16) 2003; 74 Novick (10.1016/j.cell.2015.10.072_bib45) 1999; 10 Oficjalska (10.1016/j.cell.2015.10.072_bib47) 2015; 194 Takeda (10.1016/j.cell.2015.10.072_bib61) 1998; 8 Kaser (10.1016/j.cell.2015.10.072_bib28) 2011; 68 Ten Hove (10.1016/j.cell.2015.10.072_bib63) 2001; 121 Lopetuso (10.1016/j.cell.2015.10.072_bib31) 2013; 4 Fantuzzi (10.1016/j.cell.2015.10.072_bib15) 1999; 104 McCauley (10.1016/j.cell.2015.10.072_bib35) 2015; 21 Dinarello (10.1016/j.cell.2015.10.072_bib12) 2013; 4 Siegmund (10.1016/j.cell.2015.10.072_bib57) 2001; 281 Bergstrom (10.1016/j.cell.2015.10.072_bib7) 2008; 76 Cadwell (10.1016/j.cell.2015.10.072_bib10) 2008; 456 Danese (10.1016/j.cell.2015.10.072_bib11) 2011; 365 Bauernfeind (10.1016/j.cell.2015.10.072_bib5) 2009; 183 Maloy (10.1016/j.cell.2015.10.072_bib32) 2011; 474 Ogura (10.1016/j.cell.2015.10.072_bib48) 2001; 411 Gagliani (10.1016/j.cell.2015.10.072_bib19) 2014; 26 Katz (10.1016/j.cell.2015.10.072_bib29) 2002; 129 Henao-Mejia (10.1016/j.cell.2015.10.072_bib22) 2012; 482 Mercurio (10.1016/j.cell.2015.10.072_bib38) 1997; 278 Fre (10.1016/j.cell.2015.10.072_bib18) 2005; 435 Nuding (10.1016/j.cell.2015.10.072_bib46) 2007; 56 Sivakumar (10.1016/j.cell.2015.10.072_bib58) 2002; 50 Becker (10.1016/j.cell.2015.10.072_bib6) 2006; 1 Noah (10.1016/j.cell.2015.10.072_bib44) 2010; 316 Elinav (10.1016/j.cell.2015.10.072_bib14) 2011; 145 Monteleone (10.1016/j.cell.2015.10.072_bib40) 1999; 163 Medzhitov (10.1016/j.cell.2015.10.072_bib37) 1998; 2 Netea (10.1016/j.cell.2015.10.072_bib42) 2006; 12 Born (10.1016/j.cell.2015.10.072_bib9) 1998; 273 Miao (10.1016/j.cell.2015.10.072_bib39) 2010; 11 McCormick (10.1016/j.cell.2015.10.072_bib36) 1990; 43 Bamias (10.1016/j.cell.2015.10.072_bib4) 2012; 59 Gregorieff (10.1016/j.cell.2015.10.072_bib21) 2009; 137 Wehkamp (10.1016/j.cell.2015.10.072_bib67) 2007; 23 Wang (10.1016/j.cell.2015.10.072_bib66) 2013; 153 Hoshino (10.1016/j.cell.2015.10.072_bib23) 1999; 162 Neurath (10.1016/j.cell.2015.10.072_bib43) 2014; 14 Strugala (10.1016/j.cell.2015.10.072_bib59) 2008; 62 Levy (10.1016/j.cell.2015.10.072_bib30) 2015; 163 Asquith (10.1016/j.cell.2015.10.072_bib3) 2010; 207 Adolph (10.1016/j.cell.2015.10.072_bib2) 2013; 503 Takagi (10.1016/j.cell.2015.10.072_bib60) 2003; 38 Nakamura (10.1016/j.cell.2015.10.072_bib41) 1989; 57 Salcedo (10.1016/j.cell.2015.10.072_bib52) 2010; 207 Gersemann (10.1016/j.cell.2015.10.072_bib20) 2009; 77 Saleh (10.1016/j.cell.2015.10.072_bib53) 2011; 11 Pizarro (10.1016/j.cell.2015.10.072_bib49) 1999; 162 21057511 - Nat Immunol. 2010 Dec;11(12):1136-42 11729116 - Gastroenterology. 2001 Dec;121(6):1372-9 16732281 - Nat Med. 2006 Jun;12(6):650-6 8150346 - Gut. 1994 Mar;35(3):353-9 19549527 - Gastroenterology. 2009 Oct;137(4):1333-45.e1-3 24089213 - Nature. 2013 Nov 14;503(7475):272-6 12940437 - Scand J Gastroenterol. 2003 Aug;38(8):837-44 23847622 - Front Immunol. 2013 Jul 09;4:181 11606501 - Gastroenterology. 2001 Oct;121(4):875-88 17984203 - Infect Immun. 2008 Feb;76(2):796-811 9734363 - Mol Cell. 1998 Aug;2(2):253-8 9232828 - Cell Tissue Res. 1997 Sep;289(3):499-503 26638066 - Cell. 2015 Dec 3;163(6):1310-2 17406549 - Nat Protoc. 2006;1(6):2900-4 2492265 - Infect Immun. 1989 Feb;57(2):590-5 26965960 - Trends Mol Med. 2016 Apr;22(4):269-71 20679404 - J Exp Med. 2010 Aug 2;207(8):1573-7 19281767 - Differentiation. 2009 Jan;77(1):84-94 11557635 - Am J Physiol Regul Integr Comp Physiol. 2001 Oct;281(4):R1264-73 21677746 - Nature. 2011 Jun 15;474(7351):298-306 12960225 - J Leukoc Biol. 2003 Nov;74(5):889-96 22795953 - Cytokine. 2012 Sep;59(3):451-9 12191486 - Mol Cell. 2002 Aug;10(2):417-26 22047562 - N Engl J Med. 2011 Nov 3;365(18):1713-25 22258450 - Mucosal Immunol. 2012 Mar;5(2):194-206 9792649 - J Biol Chem. 1998 Nov 6;273(45):29445-50 20346770 - Immunity. 2010 Mar 26;32(3):300-2 11385576 - Nature. 2001 May 31;411(6837):599-603 20303296 - Immunity. 2010 Mar 26;32(3):379-91 9529155 - Immunity. 1998 Mar;8(3):383-90 17653185 - Nature. 2007 Jul 26;448(7152):427-34 11385577 - Nature. 2001 May 31;411(6837):603-6 21565393 - Cell. 2011 May 27;145(5):745-57 23643243 - Cell. 2013 May 9;153(4):910-8 24948595 - Int Immunol. 2014 Sep;26(9):495-9 19786015 - Exp Cell Res. 2010 Feb 1;316(3):452-65 22297845 - Nature. 2012 Feb 01;482(7384):179-85 17545771 - Curr Opin Gastroenterol. 2007 Jul;23(4):370-8 19570822 - J Immunol. 2009 Jul 15;183(2):787-91 9697844 - Immunity. 1998 Jul;9(1):143-50 23793223 - Gut. 2014 Apr;63(4):598-609 10023777 - Immunity. 1999 Jan;10(1):127-36 24751956 - Nat Rev Immunol. 2014 May;14(5):329-42 16230531 - Genes Dev. 2005 Oct 15;19(20):2412-7 20624890 - J Exp Med. 2010 Aug 2;207(8):1625-36 15959515 - Nature. 2005 Jun 16;435(7044):959-63 18194279 - Int J Clin Pract. 2008 May;62(5):762-9 2318990 - J Clin Pathol. 1990 Feb;43(2):143-6 17456510 - Gut. 2007 Sep;56(9):1240-7 10384110 - J Immunol. 1999 Jul 1;163(1):143-7 25525875 - Cell. 2014 Dec 18;159(7):1563-77 12015290 - Development. 2002 Jun;129(11):2619-28 21984606 - Cell Mol Life Sci. 2011 Nov;68(22):3643-9 12840673 - Eur J Gastroenterol Hepatol. 2003 Jun;15(6):627-34 25548224 - J Immunol. 2015 Feb 1;194(3):1252-60 20226691 - Immunity. 2010 Mar 26;32(3):367-78 10615124 - Nat Genet. 2000 Jan;24(1):36-44 10491411 - J Clin Invest. 1999 Sep;104(6):761-7 21151034 - Nat Rev Immunol. 2011 Jan;11(1):9-20 9346484 - Science. 1997 Oct 31;278(5339):860-6 11739954 - Science. 2001 Dec 7;294(5549):2155-8 18849966 - Nature. 2008 Nov 13;456(7219):259-63 24115947 - Front Immunol. 2013 Oct 08;4:289 15959516 - Nature. 2005 Jun 16;435(7044):964-8 15861209 - Nat Rev Genet. 2005 May;6(5):376-88 12010883 - Gut. 2002 Jun;50(6):812-20 20192811 - Annu Rev Immunol. 2010;28:573-621 10352304 - J Immunol. 1999 Jun 1;162(11):6829-35 26144290 - Trends Mol Med. 2015 Aug;21(8):492-503 3949447 - Int J Tissue React. 1986;8(1):79-84 10227969 - J Immunol. 1999 May 1;162(9):5041-4 |
| References_xml | – volume: 145 start-page: 745 year: 2011 end-page: 757 ident: bib14 article-title: NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis publication-title: Cell – volume: 12 start-page: 650 year: 2006 end-page: 656 ident: bib42 article-title: Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance publication-title: Nat. Med. – volume: 59 start-page: 451 year: 2012 end-page: 459 ident: bib4 article-title: New insights into the dichotomous role of innate cytokines in gut homeostasis and inflammation publication-title: Cytokine – volume: 1 start-page: 2900 year: 2006 end-page: 2904 ident: bib6 article-title: High resolution colonoscopy in live mice publication-title: Nat. Protoc. – volume: 194 start-page: 1252 year: 2015 end-page: 1260 ident: bib47 article-title: Protective role for caspase-11 during acute experimental murine colitis publication-title: J. Immunol. – volume: 11 start-page: 1136 year: 2010 end-page: 1142 ident: bib39 article-title: Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria publication-title: Nat. Immunol. – volume: 435 start-page: 959 year: 2005 end-page: 963 ident: bib65 article-title: Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells publication-title: Nature – volume: 482 start-page: 179 year: 2012 end-page: 185 ident: bib22 article-title: Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity publication-title: Nature – volume: 24 start-page: 36 year: 2000 end-page: 44 ident: bib25 article-title: Control of endodermal endocrine development by Hes-1 publication-title: Nat. Genet. – volume: 5 start-page: 194 year: 2012 end-page: 206 ident: bib33 article-title: Colonic epithelial response to injury requires Myd88 signaling in myeloid cells publication-title: Mucosal Immunol. – volume: 162 start-page: 6829 year: 1999 end-page: 6835 ident: bib49 article-title: IL-18, a novel immunoregulatory cytokine, is up-regulated in Crohn’s disease: expression and localization in intestinal mucosal cells publication-title: J. Immunol. – volume: 21 start-page: 492 year: 2015 end-page: 503 ident: bib35 article-title: Three cheers for the goblet cell: maintaining homeostasis in mucosal epithelia publication-title: Trends Mol. Med. – volume: 273 start-page: 29445 year: 1998 end-page: 29450 ident: bib9 article-title: Cloning of a novel receptor subunit, AcPL, required for interleukin-18 signaling publication-title: J. Biol. Chem. – volume: 435 start-page: 964 year: 2005 end-page: 968 ident: bib18 article-title: Notch signals control the fate of immature progenitor cells in the intestine publication-title: Nature – volume: 62 start-page: 762 year: 2008 end-page: 769 ident: bib59 article-title: Thickness and continuity of the adherent colonic mucus barrier in active and quiescent ulcerative colitis and Crohn’s disease publication-title: Int. J. Clin. Pract. – volume: 43 start-page: 143 year: 1990 end-page: 146 ident: bib36 article-title: Mucin depletion in inflammatory bowel disease publication-title: J. Clin. Pathol. – volume: 278 start-page: 860 year: 1997 end-page: 866 ident: bib38 article-title: IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation publication-title: Science – volume: 32 start-page: 300 year: 2010 end-page: 302 ident: bib56 article-title: Interleukin-18 in intestinal inflammation: friend and foe? publication-title: Immunity – volume: 137 start-page: 1333 year: 2009 end-page: 1345 ident: bib21 article-title: The ets-domain transcription factor Spdef promotes maturation of goblet and paneth cells in the intestinal epithelium publication-title: Gastroenterology – volume: 183 start-page: 787 year: 2009 end-page: 791 ident: bib5 article-title: Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression publication-title: J. Immunol. – volume: 474 start-page: 298 year: 2011 end-page: 306 ident: bib32 article-title: Intestinal homeostasis and its breakdown in inflammatory bowel disease publication-title: Nature – volume: 281 start-page: R1264 year: 2001 end-page: R1273 ident: bib57 article-title: Neutralization of interleukin-18 reduces severity in murine colitis and intestinal IFN-gamma and TNF-alpha production publication-title: Am. J. Physiol. Regul. Integr. Comp. Physiol. – volume: 448 start-page: 427 year: 2007 end-page: 434 ident: bib68 article-title: Unravelling the pathogenesis of inflammatory bowel disease publication-title: Nature – volume: 74 start-page: 889 year: 2003 end-page: 896 ident: bib16 article-title: Generation and characterization of mice transgenic for human IL-18-binding protein isoform a publication-title: J. Leukoc. Biol. – volume: 207 start-page: 1573 year: 2010 end-page: 1577 ident: bib3 article-title: An innately dangerous balancing act: intestinal homeostasis, inflammation, and colitis-associated cancer publication-title: J. Exp. Med. – volume: 4 start-page: 289 year: 2013 ident: bib12 article-title: Interleukin-18 and IL-18 binding protein publication-title: Front. Immunol. – volume: 35 start-page: 353 year: 1994 end-page: 359 ident: bib50 article-title: Thickness of adherent mucus gel on colonic mucosa in humans and its relevance to colitis publication-title: Gut – volume: 32 start-page: 367 year: 2010 end-page: 378 ident: bib13 article-title: Control of intestinal homeostasis, colitis, and colitis-associated colorectal cancer by the inflammatory caspases publication-title: Immunity – volume: 8 start-page: 79 year: 1986 end-page: 84 ident: bib64 article-title: Differential diagnosis of Crohn’s disease of the colon from ulcerative colitis: ultrastructure study with the scanning electron microscope publication-title: Int. J. Tissue React. – volume: 63 start-page: 598 year: 2014 end-page: 609 ident: bib8 article-title: Non-redundant properties of IL-1α and IL-1β during acute colon inflammation in mice publication-title: Gut – volume: 77 start-page: 84 year: 2009 end-page: 94 ident: bib20 article-title: Differences in goblet cell differentiation between Crohn’s disease and ulcerative colitis publication-title: Differentiation – volume: 503 start-page: 272 year: 2013 end-page: 276 ident: bib2 article-title: Paneth cells as a site of origin for intestinal inflammation publication-title: Nature – volume: 6 start-page: 376 year: 2005 end-page: 388 ident: bib54 article-title: Genetics of Crohn disease, an archetypal inflammatory barrier disease publication-title: Nat. Rev. Genet. – volume: 104 start-page: 761 year: 1999 end-page: 767 ident: bib15 article-title: IL-12-induced IFN-gamma is dependent on caspase-1 processing of the IL-18 precursor publication-title: J. Clin. Invest. – volume: 56 start-page: 1240 year: 2007 end-page: 1247 ident: bib46 article-title: Reduced mucosal antimicrobial activity in Crohn’s disease of the colon publication-title: Gut – volume: 159 start-page: 1563 year: 2014 end-page: 1577 ident: bib51 article-title: Apoptotic caspases prevent the induction of type I interferons by mitochondrial DNA publication-title: Cell – volume: 10 start-page: 417 year: 2002 end-page: 426 ident: bib34 article-title: The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-β publication-title: Mol. Cell – volume: 289 start-page: 499 year: 1997 end-page: 503 ident: bib62 article-title: Immunohistochemical and immuno-electron-microscopic detection of interferon-gamma-inducing factor (“interleukin-18”) in mouse intestinal epithelial cells publication-title: Cell Tissue Res. – volume: 10 start-page: 127 year: 1999 end-page: 136 ident: bib45 article-title: Interleukin-18 binding protein: a novel modulator of the Th1 cytokine response publication-title: Immunity – volume: 11 start-page: 9 year: 2011 end-page: 20 ident: bib53 article-title: Innate immune mechanisms of colitis and colitis-associated colorectal cancer publication-title: Nat. Rev. Immunol. – volume: 26 start-page: 495 year: 2014 end-page: 499 ident: bib19 article-title: Inflammasomes and intestinal homeostasis: regulating and connecting infection, inflammation and the microbiota publication-title: Int. Immunol. – volume: 129 start-page: 2619 year: 2002 end-page: 2628 ident: bib29 article-title: The zinc-finger transcription factor Klf4 is required for terminal differentiation of goblet cells in the colon publication-title: Development – volume: 38 start-page: 837 year: 2003 end-page: 844 ident: bib60 article-title: Contrasting action of IL-12 and IL-18 in the development of dextran sodium sulphate colitis in mice publication-title: Scand. J. Gastroenterol. – volume: 28 start-page: 573 year: 2010 end-page: 621 ident: bib27 article-title: Inflammatory bowel disease publication-title: Annu. Rev. Immunol. – volume: 76 start-page: 796 year: 2008 end-page: 811 ident: bib7 article-title: Modulation of intestinal goblet cell function during infection by an attaching and effacing bacterial pathogen publication-title: Infect. Immun. – volume: 411 start-page: 599 year: 2001 end-page: 603 ident: bib24 article-title: Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn’s disease publication-title: Nature – volume: 162 start-page: 5041 year: 1999 end-page: 5044 ident: bib23 article-title: Cutting edge: generation of IL-18 receptor-deficient mice: evidence for IL-1 receptor-related protein as an essential IL-18 binding receptor publication-title: J. Immunol. – volume: 121 start-page: 1372 year: 2001 end-page: 1379 ident: bib63 article-title: Blockade of endogenous IL-18 ameliorates TNBS-induced colitis by decreasing local TNF-alpha production in mice publication-title: Gastroenterology – volume: 68 start-page: 3643 year: 2011 end-page: 3649 ident: bib28 article-title: Genetically determined epithelial dysfunction and its consequences for microflora-host interactions publication-title: Cell. Mol. Life Sci. – volume: 19 start-page: 2412 year: 2005 end-page: 2417 ident: bib55 article-title: Gfi1 functions downstream of Math1 to control intestinal secretory cell subtype allocation and differentiation publication-title: Genes Dev. – volume: 57 start-page: 590 year: 1989 end-page: 595 ident: bib41 article-title: Endotoxin-induced serum factor that stimulates gamma interferon production publication-title: Infect. Immun. – volume: 163 start-page: 1428 year: 2015 end-page: 1443 ident: bib30 article-title: Microbiota-modulated metabolites shape the intestinal microenvironment by regulating NLRP6 inflammasome signaling publication-title: Cell – volume: 4 start-page: 181 year: 2013 ident: bib31 article-title: Opposing functions of classic and novel IL-1 family members in gut health and disease publication-title: Front. Immunol. – volume: 365 start-page: 1713 year: 2011 end-page: 1725 ident: bib11 article-title: Ulcerative colitis publication-title: N. Engl. J. Med. – volume: 163 start-page: 143 year: 1999 end-page: 147 ident: bib40 article-title: Bioactive IL-18 expression is up-regulated in Crohn’s disease publication-title: J. Immunol. – volume: 411 start-page: 603 year: 2001 end-page: 606 ident: bib48 article-title: A frameshift mutation in NOD2 associated with susceptibility to Crohn’s disease publication-title: Nature – volume: 121 start-page: 875 year: 2001 end-page: 888 ident: bib26 article-title: Macrophage-derived IL-18-mediated intestinal inflammation in the murine model of Crohn’s disease publication-title: Gastroenterology – volume: 2 start-page: 253 year: 1998 end-page: 258 ident: bib37 article-title: MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways publication-title: Mol. Cell – volume: 15 start-page: 627 year: 2003 end-page: 634 ident: bib17 article-title: Crohn’s disease: a defensin deficiency syndrome? publication-title: Eur. J. Gastroenterol. Hepatol. – volume: 316 start-page: 452 year: 2010 end-page: 465 ident: bib44 article-title: SAM pointed domain ETS factor (SPDEF) regulates terminal differentiation and maturation of intestinal goblet cells publication-title: Exp. Cell Res. – volume: 50 start-page: 812 year: 2002 end-page: 820 ident: bib58 article-title: Interleukin 18 is a primary mediator of the inflammation associated with dextran sulphate sodium induced colitis: blocking interleukin 18 attenuates intestinal damage publication-title: Gut – volume: 9 start-page: 143 year: 1998 end-page: 150 ident: bib1 article-title: Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function publication-title: Immunity – volume: 14 start-page: 329 year: 2014 end-page: 342 ident: bib43 article-title: Cytokines in inflammatory bowel disease publication-title: Nat. Rev. Immunol. – volume: 153 start-page: 910 year: 2013 end-page: 918 ident: bib66 article-title: One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering publication-title: Cell – volume: 207 start-page: 1625 year: 2010 end-page: 1636 ident: bib52 article-title: MyD88-mediated signaling prevents development of adenocarcinomas of the colon: role of interleukin 18 publication-title: J. Exp. Med. – volume: 456 start-page: 259 year: 2008 end-page: 263 ident: bib10 article-title: A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells publication-title: Nature – volume: 32 start-page: 379 year: 2010 end-page: 391 ident: bib70 article-title: The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis publication-title: Immunity – volume: 8 start-page: 383 year: 1998 end-page: 390 ident: bib61 article-title: Defective NK cell activity and Th1 response in IL-18-deficient mice publication-title: Immunity – volume: 23 start-page: 370 year: 2007 end-page: 378 ident: bib67 article-title: Defensins and other antimicrobial peptides in inflammatory bowel disease publication-title: Curr. Opin. Gastroenterol. – volume: 294 start-page: 2155 year: 2001 end-page: 2158 ident: bib69 article-title: Requirement of Math1 for secretory cell lineage commitment in the mouse intestine publication-title: Science – volume: 411 start-page: 599 year: 2001 ident: 10.1016/j.cell.2015.10.072_bib24 article-title: Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn’s disease publication-title: Nature doi: 10.1038/35079107 – volume: 163 start-page: 143 year: 1999 ident: 10.1016/j.cell.2015.10.072_bib40 article-title: Bioactive IL-18 expression is up-regulated in Crohn’s disease publication-title: J. Immunol. doi: 10.4049/jimmunol.163.1.143 – volume: 62 start-page: 762 year: 2008 ident: 10.1016/j.cell.2015.10.072_bib59 article-title: Thickness and continuity of the adherent colonic mucus barrier in active and quiescent ulcerative colitis and Crohn’s disease publication-title: Int. J. Clin. Pract. doi: 10.1111/j.1742-1241.2007.01665.x – volume: 121 start-page: 1372 year: 2001 ident: 10.1016/j.cell.2015.10.072_bib63 article-title: Blockade of endogenous IL-18 ameliorates TNBS-induced colitis by decreasing local TNF-alpha production in mice publication-title: Gastroenterology doi: 10.1053/gast.2001.29579 – volume: 77 start-page: 84 year: 2009 ident: 10.1016/j.cell.2015.10.072_bib20 article-title: Differences in goblet cell differentiation between Crohn’s disease and ulcerative colitis publication-title: Differentiation doi: 10.1016/j.diff.2008.09.008 – volume: 294 start-page: 2155 year: 2001 ident: 10.1016/j.cell.2015.10.072_bib69 article-title: Requirement of Math1 for secretory cell lineage commitment in the mouse intestine publication-title: Science doi: 10.1126/science.1065718 – volume: 273 start-page: 29445 year: 1998 ident: 10.1016/j.cell.2015.10.072_bib9 article-title: Cloning of a novel receptor subunit, AcPL, required for interleukin-18 signaling publication-title: J. Biol. Chem. doi: 10.1074/jbc.273.45.29445 – volume: 24 start-page: 36 year: 2000 ident: 10.1016/j.cell.2015.10.072_bib25 article-title: Control of endodermal endocrine development by Hes-1 publication-title: Nat. Genet. doi: 10.1038/71657 – volume: 12 start-page: 650 year: 2006 ident: 10.1016/j.cell.2015.10.072_bib42 article-title: Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance publication-title: Nat. Med. doi: 10.1038/nm1415 – volume: 448 start-page: 427 year: 2007 ident: 10.1016/j.cell.2015.10.072_bib68 article-title: Unravelling the pathogenesis of inflammatory bowel disease publication-title: Nature doi: 10.1038/nature06005 – volume: 162 start-page: 6829 year: 1999 ident: 10.1016/j.cell.2015.10.072_bib49 article-title: IL-18, a novel immunoregulatory cytokine, is up-regulated in Crohn’s disease: expression and localization in intestinal mucosal cells publication-title: J. Immunol. doi: 10.4049/jimmunol.162.11.6829 – volume: 11 start-page: 9 year: 2011 ident: 10.1016/j.cell.2015.10.072_bib53 article-title: Innate immune mechanisms of colitis and colitis-associated colorectal cancer publication-title: Nat. Rev. Immunol. doi: 10.1038/nri2891 – volume: 162 start-page: 5041 year: 1999 ident: 10.1016/j.cell.2015.10.072_bib23 article-title: Cutting edge: generation of IL-18 receptor-deficient mice: evidence for IL-1 receptor-related protein as an essential IL-18 binding receptor publication-title: J. Immunol. doi: 10.4049/jimmunol.162.9.5041 – volume: 207 start-page: 1625 year: 2010 ident: 10.1016/j.cell.2015.10.072_bib52 article-title: MyD88-mediated signaling prevents development of adenocarcinomas of the colon: role of interleukin 18 publication-title: J. Exp. Med. doi: 10.1084/jem.20100199 – volume: 26 start-page: 495 year: 2014 ident: 10.1016/j.cell.2015.10.072_bib19 article-title: Inflammasomes and intestinal homeostasis: regulating and connecting infection, inflammation and the microbiota publication-title: Int. Immunol. doi: 10.1093/intimm/dxu066 – volume: 153 start-page: 910 year: 2013 ident: 10.1016/j.cell.2015.10.072_bib66 article-title: One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering publication-title: Cell doi: 10.1016/j.cell.2013.04.025 – volume: 503 start-page: 272 year: 2013 ident: 10.1016/j.cell.2015.10.072_bib2 article-title: Paneth cells as a site of origin for intestinal inflammation publication-title: Nature doi: 10.1038/nature12599 – volume: 15 start-page: 627 year: 2003 ident: 10.1016/j.cell.2015.10.072_bib17 article-title: Crohn’s disease: a defensin deficiency syndrome? publication-title: Eur. J. Gastroenterol. Hepatol. doi: 10.1097/00042737-200306000-00008 – volume: 482 start-page: 179 year: 2012 ident: 10.1016/j.cell.2015.10.072_bib22 article-title: Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity publication-title: Nature doi: 10.1038/nature10809 – volume: 6 start-page: 376 year: 2005 ident: 10.1016/j.cell.2015.10.072_bib54 article-title: Genetics of Crohn disease, an archetypal inflammatory barrier disease publication-title: Nat. Rev. Genet. doi: 10.1038/nrg1607 – volume: 281 start-page: R1264 year: 2001 ident: 10.1016/j.cell.2015.10.072_bib57 article-title: Neutralization of interleukin-18 reduces severity in murine colitis and intestinal IFN-gamma and TNF-alpha production publication-title: Am. J. Physiol. Regul. Integr. Comp. Physiol. doi: 10.1152/ajpregu.2001.281.4.R1264 – volume: 50 start-page: 812 year: 2002 ident: 10.1016/j.cell.2015.10.072_bib58 article-title: Interleukin 18 is a primary mediator of the inflammation associated with dextran sulphate sodium induced colitis: blocking interleukin 18 attenuates intestinal damage publication-title: Gut doi: 10.1136/gut.50.6.812 – volume: 56 start-page: 1240 year: 2007 ident: 10.1016/j.cell.2015.10.072_bib46 article-title: Reduced mucosal antimicrobial activity in Crohn’s disease of the colon publication-title: Gut doi: 10.1136/gut.2006.118646 – volume: 32 start-page: 300 year: 2010 ident: 10.1016/j.cell.2015.10.072_bib56 article-title: Interleukin-18 in intestinal inflammation: friend and foe? publication-title: Immunity doi: 10.1016/j.immuni.2010.03.010 – volume: 365 start-page: 1713 year: 2011 ident: 10.1016/j.cell.2015.10.072_bib11 article-title: Ulcerative colitis publication-title: N. Engl. J. Med. doi: 10.1056/NEJMra1102942 – volume: 474 start-page: 298 year: 2011 ident: 10.1016/j.cell.2015.10.072_bib32 article-title: Intestinal homeostasis and its breakdown in inflammatory bowel disease publication-title: Nature doi: 10.1038/nature10208 – volume: 104 start-page: 761 year: 1999 ident: 10.1016/j.cell.2015.10.072_bib15 article-title: IL-12-induced IFN-gamma is dependent on caspase-1 processing of the IL-18 precursor publication-title: J. Clin. Invest. doi: 10.1172/JCI7501 – volume: 43 start-page: 143 year: 1990 ident: 10.1016/j.cell.2015.10.072_bib36 article-title: Mucin depletion in inflammatory bowel disease publication-title: J. Clin. Pathol. doi: 10.1136/jcp.43.2.143 – volume: 183 start-page: 787 year: 2009 ident: 10.1016/j.cell.2015.10.072_bib5 article-title: Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression publication-title: J. Immunol. doi: 10.4049/jimmunol.0901363 – volume: 8 start-page: 383 year: 1998 ident: 10.1016/j.cell.2015.10.072_bib61 article-title: Defective NK cell activity and Th1 response in IL-18-deficient mice publication-title: Immunity doi: 10.1016/S1074-7613(00)80543-9 – volume: 32 start-page: 367 year: 2010 ident: 10.1016/j.cell.2015.10.072_bib13 article-title: Control of intestinal homeostasis, colitis, and colitis-associated colorectal cancer by the inflammatory caspases publication-title: Immunity doi: 10.1016/j.immuni.2010.02.012 – volume: 76 start-page: 796 year: 2008 ident: 10.1016/j.cell.2015.10.072_bib7 article-title: Modulation of intestinal goblet cell function during infection by an attaching and effacing bacterial pathogen publication-title: Infect. Immun. doi: 10.1128/IAI.00093-07 – volume: 435 start-page: 959 year: 2005 ident: 10.1016/j.cell.2015.10.072_bib65 article-title: Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells publication-title: Nature doi: 10.1038/nature03659 – volume: 121 start-page: 875 year: 2001 ident: 10.1016/j.cell.2015.10.072_bib26 article-title: Macrophage-derived IL-18-mediated intestinal inflammation in the murine model of Crohn’s disease publication-title: Gastroenterology doi: 10.1053/gast.2001.28021 – volume: 207 start-page: 1573 year: 2010 ident: 10.1016/j.cell.2015.10.072_bib3 article-title: An innately dangerous balancing act: intestinal homeostasis, inflammation, and colitis-associated cancer publication-title: J. Exp. Med. doi: 10.1084/jem.20101330 – volume: 59 start-page: 451 year: 2012 ident: 10.1016/j.cell.2015.10.072_bib4 article-title: New insights into the dichotomous role of innate cytokines in gut homeostasis and inflammation publication-title: Cytokine doi: 10.1016/j.cyto.2012.06.014 – volume: 21 start-page: 492 year: 2015 ident: 10.1016/j.cell.2015.10.072_bib35 article-title: Three cheers for the goblet cell: maintaining homeostasis in mucosal epithelia publication-title: Trends Mol. Med. doi: 10.1016/j.molmed.2015.06.003 – volume: 10 start-page: 127 year: 1999 ident: 10.1016/j.cell.2015.10.072_bib45 article-title: Interleukin-18 binding protein: a novel modulator of the Th1 cytokine response publication-title: Immunity doi: 10.1016/S1074-7613(00)80013-8 – volume: 137 start-page: 1333 year: 2009 ident: 10.1016/j.cell.2015.10.072_bib21 article-title: The ets-domain transcription factor Spdef promotes maturation of goblet and paneth cells in the intestinal epithelium publication-title: Gastroenterology doi: 10.1053/j.gastro.2009.06.044 – volume: 8 start-page: 79 year: 1986 ident: 10.1016/j.cell.2015.10.072_bib64 article-title: Differential diagnosis of Crohn’s disease of the colon from ulcerative colitis: ultrastructure study with the scanning electron microscope publication-title: Int. J. Tissue React. – volume: 129 start-page: 2619 year: 2002 ident: 10.1016/j.cell.2015.10.072_bib29 article-title: The zinc-finger transcription factor Klf4 is required for terminal differentiation of goblet cells in the colon publication-title: Development doi: 10.1242/dev.129.11.2619 – volume: 28 start-page: 573 year: 2010 ident: 10.1016/j.cell.2015.10.072_bib27 article-title: Inflammatory bowel disease publication-title: Annu. Rev. Immunol. doi: 10.1146/annurev-immunol-030409-101225 – volume: 19 start-page: 2412 year: 2005 ident: 10.1016/j.cell.2015.10.072_bib55 article-title: Gfi1 functions downstream of Math1 to control intestinal secretory cell subtype allocation and differentiation publication-title: Genes Dev. doi: 10.1101/gad.1353905 – volume: 63 start-page: 598 year: 2014 ident: 10.1016/j.cell.2015.10.072_bib8 article-title: Non-redundant properties of IL-1α and IL-1β during acute colon inflammation in mice publication-title: Gut doi: 10.1136/gutjnl-2012-303329 – volume: 2 start-page: 253 year: 1998 ident: 10.1016/j.cell.2015.10.072_bib37 article-title: MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways publication-title: Mol. Cell doi: 10.1016/S1097-2765(00)80136-7 – volume: 32 start-page: 379 year: 2010 ident: 10.1016/j.cell.2015.10.072_bib70 article-title: The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis publication-title: Immunity doi: 10.1016/j.immuni.2010.03.003 – volume: 4 start-page: 181 year: 2013 ident: 10.1016/j.cell.2015.10.072_bib31 article-title: Opposing functions of classic and novel IL-1 family members in gut health and disease publication-title: Front. Immunol. doi: 10.3389/fimmu.2013.00181 – volume: 278 start-page: 860 year: 1997 ident: 10.1016/j.cell.2015.10.072_bib38 article-title: IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation publication-title: Science doi: 10.1126/science.278.5339.860 – volume: 145 start-page: 745 year: 2011 ident: 10.1016/j.cell.2015.10.072_bib14 article-title: NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis publication-title: Cell doi: 10.1016/j.cell.2011.04.022 – volume: 11 start-page: 1136 year: 2010 ident: 10.1016/j.cell.2015.10.072_bib39 article-title: Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria publication-title: Nat. Immunol. doi: 10.1038/ni.1960 – volume: 163 start-page: 1428 year: 2015 ident: 10.1016/j.cell.2015.10.072_bib30 article-title: Microbiota-modulated metabolites shape the intestinal microenvironment by regulating NLRP6 inflammasome signaling publication-title: Cell doi: 10.1016/j.cell.2015.10.048 – volume: 159 start-page: 1563 year: 2014 ident: 10.1016/j.cell.2015.10.072_bib51 article-title: Apoptotic caspases prevent the induction of type I interferons by mitochondrial DNA publication-title: Cell doi: 10.1016/j.cell.2014.11.037 – volume: 289 start-page: 499 year: 1997 ident: 10.1016/j.cell.2015.10.072_bib62 article-title: Immunohistochemical and immuno-electron-microscopic detection of interferon-gamma-inducing factor (“interleukin-18”) in mouse intestinal epithelial cells publication-title: Cell Tissue Res. doi: 10.1007/s004410050895 – volume: 10 start-page: 417 year: 2002 ident: 10.1016/j.cell.2015.10.072_bib34 article-title: The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-β publication-title: Mol. Cell doi: 10.1016/S1097-2765(02)00599-3 – volume: 23 start-page: 370 year: 2007 ident: 10.1016/j.cell.2015.10.072_bib67 article-title: Defensins and other antimicrobial peptides in inflammatory bowel disease publication-title: Curr. Opin. Gastroenterol. doi: 10.1097/MOG.0b013e328136c580 – volume: 9 start-page: 143 year: 1998 ident: 10.1016/j.cell.2015.10.072_bib1 article-title: Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function publication-title: Immunity doi: 10.1016/S1074-7613(00)80596-8 – volume: 35 start-page: 353 year: 1994 ident: 10.1016/j.cell.2015.10.072_bib50 article-title: Thickness of adherent mucus gel on colonic mucosa in humans and its relevance to colitis publication-title: Gut doi: 10.1136/gut.35.3.353 – volume: 316 start-page: 452 year: 2010 ident: 10.1016/j.cell.2015.10.072_bib44 article-title: SAM pointed domain ETS factor (SPDEF) regulates terminal differentiation and maturation of intestinal goblet cells publication-title: Exp. Cell Res. doi: 10.1016/j.yexcr.2009.09.020 – volume: 4 start-page: 289 year: 2013 ident: 10.1016/j.cell.2015.10.072_bib12 article-title: Interleukin-18 and IL-18 binding protein publication-title: Front. Immunol. doi: 10.3389/fimmu.2013.00289 – volume: 411 start-page: 603 year: 2001 ident: 10.1016/j.cell.2015.10.072_bib48 article-title: A frameshift mutation in NOD2 associated with susceptibility to Crohn’s disease publication-title: Nature doi: 10.1038/35079114 – volume: 14 start-page: 329 year: 2014 ident: 10.1016/j.cell.2015.10.072_bib43 article-title: Cytokines in inflammatory bowel disease publication-title: Nat. Rev. Immunol. doi: 10.1038/nri3661 – volume: 456 start-page: 259 year: 2008 ident: 10.1016/j.cell.2015.10.072_bib10 article-title: A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells publication-title: Nature doi: 10.1038/nature07416 – volume: 194 start-page: 1252 year: 2015 ident: 10.1016/j.cell.2015.10.072_bib47 article-title: Protective role for caspase-11 during acute experimental murine colitis publication-title: J. Immunol. doi: 10.4049/jimmunol.1400501 – volume: 1 start-page: 2900 year: 2006 ident: 10.1016/j.cell.2015.10.072_bib6 article-title: High resolution colonoscopy in live mice publication-title: Nat. Protoc. doi: 10.1038/nprot.2006.446 – volume: 57 start-page: 590 year: 1989 ident: 10.1016/j.cell.2015.10.072_bib41 article-title: Endotoxin-induced serum factor that stimulates gamma interferon production publication-title: Infect. Immun. doi: 10.1128/iai.57.2.590-595.1989 – volume: 68 start-page: 3643 year: 2011 ident: 10.1016/j.cell.2015.10.072_bib28 article-title: Genetically determined epithelial dysfunction and its consequences for microflora-host interactions publication-title: Cell. Mol. Life Sci. doi: 10.1007/s00018-011-0827-y – volume: 5 start-page: 194 year: 2012 ident: 10.1016/j.cell.2015.10.072_bib33 article-title: Colonic epithelial response to injury requires Myd88 signaling in myeloid cells publication-title: Mucosal Immunol. doi: 10.1038/mi.2011.65 – volume: 74 start-page: 889 year: 2003 ident: 10.1016/j.cell.2015.10.072_bib16 article-title: Generation and characterization of mice transgenic for human IL-18-binding protein isoform a publication-title: J. Leukoc. Biol. doi: 10.1189/jlb.0503230 – volume: 38 start-page: 837 year: 2003 ident: 10.1016/j.cell.2015.10.072_bib60 article-title: Contrasting action of IL-12 and IL-18 in the development of dextran sodium sulphate colitis in mice publication-title: Scand. J. Gastroenterol. doi: 10.1080/00365520310004047 – volume: 435 start-page: 964 year: 2005 ident: 10.1016/j.cell.2015.10.072_bib18 article-title: Notch signals control the fate of immature progenitor cells in the intestine publication-title: Nature doi: 10.1038/nature03589 – reference: 9232828 - Cell Tissue Res. 1997 Sep;289(3):499-503 – reference: 19549527 - Gastroenterology. 2009 Oct;137(4):1333-45.e1-3 – reference: 11729116 - Gastroenterology. 2001 Dec;121(6):1372-9 – reference: 9734363 - Mol Cell. 1998 Aug;2(2):253-8 – reference: 18849966 - Nature. 2008 Nov 13;456(7219):259-63 – reference: 16732281 - Nat Med. 2006 Jun;12(6):650-6 – reference: 22795953 - Cytokine. 2012 Sep;59(3):451-9 – reference: 17406549 - Nat Protoc. 2006;1(6):2900-4 – reference: 24089213 - Nature. 2013 Nov 14;503(7475):272-6 – reference: 26965960 - Trends Mol Med. 2016 Apr;22(4):269-71 – reference: 21565393 - Cell. 2011 May 27;145(5):745-57 – reference: 12960225 - J Leukoc Biol. 2003 Nov;74(5):889-96 – reference: 9346484 - Science. 1997 Oct 31;278(5339):860-6 – reference: 20226691 - Immunity. 2010 Mar 26;32(3):367-78 – reference: 21984606 - Cell Mol Life Sci. 2011 Nov;68(22):3643-9 – reference: 20192811 - Annu Rev Immunol. 2010;28:573-621 – reference: 24948595 - Int Immunol. 2014 Sep;26(9):495-9 – reference: 10384110 - J Immunol. 1999 Jul 1;163(1):143-7 – reference: 16230531 - Genes Dev. 2005 Oct 15;19(20):2412-7 – reference: 10227969 - J Immunol. 1999 May 1;162(9):5041-4 – reference: 11606501 - Gastroenterology. 2001 Oct;121(4):875-88 – reference: 20679404 - J Exp Med. 2010 Aug 2;207(8):1573-7 – reference: 24751956 - Nat Rev Immunol. 2014 May;14(5):329-42 – reference: 26144290 - Trends Mol Med. 2015 Aug;21(8):492-503 – reference: 10615124 - Nat Genet. 2000 Jan;24(1):36-44 – reference: 21151034 - Nat Rev Immunol. 2011 Jan;11(1):9-20 – reference: 19281767 - Differentiation. 2009 Jan;77(1):84-94 – reference: 24115947 - Front Immunol. 2013 Oct 08;4:289 – reference: 15861209 - Nat Rev Genet. 2005 May;6(5):376-88 – reference: 12191486 - Mol Cell. 2002 Aug;10(2):417-26 – reference: 11557635 - Am J Physiol Regul Integr Comp Physiol. 2001 Oct;281(4):R1264-73 – reference: 21677746 - Nature. 2011 Jun 15;474(7351):298-306 – reference: 22258450 - Mucosal Immunol. 2012 Mar;5(2):194-206 – reference: 22297845 - Nature. 2012 Feb 01;482(7384):179-85 – reference: 12840673 - Eur J Gastroenterol Hepatol. 2003 Jun;15(6):627-34 – reference: 23847622 - Front Immunol. 2013 Jul 09;4:181 – reference: 26638066 - Cell. 2015 Dec 3;163(6):1310-2 – reference: 11385577 - Nature. 2001 May 31;411(6837):603-6 – reference: 3949447 - Int J Tissue React. 1986;8(1):79-84 – reference: 9697844 - Immunity. 1998 Jul;9(1):143-50 – reference: 8150346 - Gut. 1994 Mar;35(3):353-9 – reference: 12940437 - Scand J Gastroenterol. 2003 Aug;38(8):837-44 – reference: 18194279 - Int J Clin Pract. 2008 May;62(5):762-9 – reference: 25548224 - J Immunol. 2015 Feb 1;194(3):1252-60 – reference: 10023777 - Immunity. 1999 Jan;10(1):127-36 – reference: 20624890 - J Exp Med. 2010 Aug 2;207(8):1625-36 – reference: 11385576 - Nature. 2001 May 31;411(6837):599-603 – reference: 2492265 - Infect Immun. 1989 Feb;57(2):590-5 – reference: 19570822 - J Immunol. 2009 Jul 15;183(2):787-91 – reference: 17456510 - Gut. 2007 Sep;56(9):1240-7 – reference: 25525875 - Cell. 2014 Dec 18;159(7):1563-77 – reference: 21057511 - Nat Immunol. 2010 Dec;11(12):1136-42 – reference: 9529155 - Immunity. 1998 Mar;8(3):383-90 – reference: 15959515 - Nature. 2005 Jun 16;435(7044):959-63 – reference: 17653185 - Nature. 2007 Jul 26;448(7152):427-34 – reference: 20346770 - Immunity. 2010 Mar 26;32(3):300-2 – reference: 12010883 - Gut. 2002 Jun;50(6):812-20 – reference: 2318990 - J Clin Pathol. 1990 Feb;43(2):143-6 – reference: 9792649 - J Biol Chem. 1998 Nov 6;273(45):29445-50 – reference: 20303296 - Immunity. 2010 Mar 26;32(3):379-91 – reference: 10491411 - J Clin Invest. 1999 Sep;104(6):761-7 – reference: 19786015 - Exp Cell Res. 2010 Feb 1;316(3):452-65 – reference: 12015290 - Development. 2002 Jun;129(11):2619-28 – reference: 15959516 - Nature. 2005 Jun 16;435(7044):964-8 – reference: 23793223 - Gut. 2014 Apr;63(4):598-609 – reference: 23643243 - Cell. 2013 May 9;153(4):910-8 – reference: 11739954 - Science. 2001 Dec 7;294(5549):2155-8 – reference: 17984203 - Infect Immun. 2008 Feb;76(2):796-811 – reference: 17545771 - Curr Opin Gastroenterol. 2007 Jul;23(4):370-8 – reference: 10352304 - J Immunol. 1999 Jun 1;162(11):6829-35 – reference: 22047562 - N Engl J Med. 2011 Nov 3;365(18):1713-25 |
| SSID | ssj0008555 |
| Score | 2.6337464 |
| Snippet | The intestinal mucosal barrier controlling the resident microbiome is dependent on a protective mucus layer generated by goblet cells, impairment of which is a... |
| SourceID | pubmedcentral proquest pubmed crossref elsevier |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 1444 |
| SubjectTerms | Animals Colitis, Ulcerative - chemically induced Colitis, Ulcerative - metabolism Colitis, Ulcerative - pathology Colitis, Ulcerative - physiopathology Dextran Sulfate Endothelial Cells - metabolism Epithelial Cells - cytology epithelium Female Goblet Cells - metabolism Goblet Cells - pathology Intercellular Signaling Peptides and Proteins - genetics Intercellular Signaling Peptides and Proteins - metabolism interleukin-18 Interleukin-18 - immunology Interleukin-18 Receptor alpha Subunit - genetics Interleukin-18 Receptor alpha Subunit - metabolism Intestinal Mucosa - physiopathology intestines Male Mice microbiome mucus Signal Transduction transcription (genetics) ulcerative colitis |
| Title | Epithelial IL-18 Equilibrium Controls Barrier Function in Colitis |
| URI | https://dx.doi.org/10.1016/j.cell.2015.10.072 https://www.ncbi.nlm.nih.gov/pubmed/26638073 https://www.proquest.com/docview/1746871929 https://www.proquest.com/docview/2000235500 https://pubmed.ncbi.nlm.nih.gov/PMC4943028 |
| Volume | 163 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LS8NAEF5KQfAivo0vIniT2Dw2ye6xLS1V1JOF3sIm2cVITWvbHPz3zmSTYJX24DHZDSQzuzPfhm--IeQWkkoYqyC1BORvi4YxbCkeCosHiiqRuooHWO_8_BKMxvRx4k9apF_XwiCtsor9OqaX0bq606ms2ZlnGdb4cpcFmBFtlA3DOOxRVhbxTXpNNGa-r7sYcNj5MLsqnNEcL_w5jvQu_x4ZXqG7KTn9BZ-_OZQ_ktJwn-xVaNLs6hc-IC2ZH5Id3V_y64h0B3MsuZjCGjMfniyHmYPPIitZ_sWH2dcs9aXZEwvsW2cOIcehn8wsh0HkxS2PyXg4eO2PrKpngpUAMFhZSnDJuM1iO4UvT3nMHEeGCRxSPKWUrRLueCJQrhQS1c18LlDASyTCcyUNE-qdkHY-y-UZMQGbARxyUxkrRgUgB5niYU4mAMo5pYlBnNpYUVIJimNfi2lUM8feIzRwhAbGe2Bgg9w1z8y1nMbW2X7tg2htUUQQ77c-d1M7LILdgsMil7NiGcH5K4AjImDCzXNcLQLk27ZBTrWTm3cFOIMK_Z5BwjX3NxNQrXt9JM_eStVuikL3Ljv_5zddkF28Kpk03iVprxaFvAI8tIqvywX_DYSmB9I |
| linkProvider | Elsevier |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LT8MwDLYQCMEF8WY8i8QNFfpIHzlu06YNBieQdovSNhFFowy2Hfj32E07MRAcuDaJ1NqJ_aX6_BngApNKlOgwsyXmb5tFCR4pHkmbh5ppmXmah1TvfHcf9h7ZzTAYLkG7roUhWmUV-01ML6N19eS6sub1OM-pxpd7cUgZ0SHZMIzDK4gGIurf0B-25uE4DgLTxoDj0cfpVeWMIXnR33HidwVXRPGKvN-y00_0-Z1E-SUrdTdho4KTVtO88RYsqWIbVk2DyY8daHbGVHMxwk1m9Qe2G1udt1le0vxnL1bb0NQnVku-U-M6q4tJjhxl5QUOEjFusguP3c5Du2dXTRPsFJHB1NaSq5g7ceJk-OUZT2LXVVGKtxRfa-3olLu-DLWnpCJ5s4BLUvCSqfQ9xaKU-XuwXLwW6gAsBGeIh7xMJTpmEqGDyug2p1JE5ZyxtAFubSyRVori1NhiJGrq2LMgAwsyMD1DAzfgcr5mbPQ0_pwd1D4QC7tCYMD_c9157TCBx4WGZaFeZxOBF7AQ74gICn-f4xkVoMBxGrBvnDx_V8QzJNHvNyBacP98Asl1L44U-VMp281I6d6LD__5TWew1nu4G4hB__72CNZppKTV-MewPH2fqRMER9PktNz8n8cgCvE |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Epithelial+IL-18+Equilibrium+Controls+Barrier+Function+in+Colitis&rft.jtitle=Cell&rft.au=Nowarski%2C+Roni&rft.au=Jackson%2C+Ruaidhr%C3%AD&rft.au=Gagliani%2C+Nicola&rft.au=de%C2%A0Zoete%2C+Marcel%C2%A0R.&rft.date=2015-12-03&rft.pub=Elsevier+Inc&rft.issn=0092-8674&rft.eissn=1097-4172&rft.volume=163&rft.issue=6&rft.spage=1444&rft.epage=1456&rft_id=info:doi/10.1016%2Fj.cell.2015.10.072&rft.externalDocID=S0092867415014282 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0092-8674&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0092-8674&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0092-8674&client=summon |