Bacterial sepsis causes more dramatic pathogenetic changes in the Th1 pathway than does viral (COVID-19) sepsis: a prospective observational study of whole blood transcriptomes - Muratsu, Arisa; Oda, Sayaka; Onishi, Shinya; Yoshimura, Jumpei; Matsumoto, Hisatake; Togami, Yuki; Mitsuyama, Yumi; Ito, Hiroshi; Okuzaki, Daisuke; Ogura, Hiroshi; Oda, Jun (Virology journal, 2024)
Keywords: Adult; Aged; Aged, 80 and over; Analysis; Bacterial infections; Bacterial Infections - blood; Bacterial pneumonia; Bacterial sepsis; Blood; Causes of; Cellular signal transduction; chest; Comparative analysis; COVID-19; COVID-19 - blood; COVID-19 - complications; COVID-19 infection; Emergency medicine; Female; Gene expression; Gene Expression Profiling; Genes; Genetic aspects; Health aspects; Humans; Immunotherapy; Male; Medical research; medicine; Medicine, Experimental; Messenger RNA; MicroRNA; MicroRNAs - blood; MicroRNAs - genetics; Middle Aged; observational studies; PD-1 and PD-L1 cancer immunotherapy signaling pathways; Physiological aspects; Pneumonia; Prospective Studies; RNA sequencing; RNA, Messenger - blood; RNA, Messenger - genetics; SARS-CoV-2 - genetics; Sepsis; Sepsis - blood; Sepsis - genetics; Severe acute respiratory syndrome coronavirus 2; T cells; Th1 Cells - immunology; Th1 signaling; tomography; Transcriptome; universities; Whole blood transcriptome; Japan; COVID-19; Th1 signaling; Bacterial sepsis; PD-1 and PD-L1 cancer immunotherapy signaling pathways; Whole blood transcriptome