Pulmonary Arterial Hypertension
Pulmonary Arterial Hypertension Kelly M. Chin, Lewis J. Rubin Significant advances in the treatment of pulmonary arterial hypertension have occurred over the last 10 years, starting with the approval of epoprostenol in 1998, followed by the development of subcutaneous and inhaled prostacyclins, oral...
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| Published in | Journal of the American College of Cardiology Vol. 51; no. 16; pp. 1527 - 1538 |
|---|---|
| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
New York, NY
Elsevier Inc
22.04.2008
Elsevier Science Elsevier Limited |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Pulmonary Arterial Hypertension
Kelly M. Chin, Lewis J. Rubin
Significant advances in the treatment of pulmonary arterial hypertension have occurred over the last 10 years, starting with the approval of epoprostenol in 1998, followed by the development of subcutaneous and inhaled prostacyclins, oral endothelin antagonists, and oral phosphodiesterase type-5 inhibitors. Combination therapy is more frequently being used, and limited data on novel therapies such as stem cell transplantation have been published. The purpose of this review is to describe the current state of evidence for the diagnosis, prognosis, and treatment of the patient with pulmonary arterial hypertension.
Significant advances in the treatment of pulmonary arterial hypertension (PAH) have occurred over the last 10 years, starting with the approval of epoprostenol in 1998. Subsequently, multiple additional medications have received approval, including a subcutaneous prostacyclin, an inhaled prostacyclin, and oral medications in 2 separate classes. Over this same period, the classification of pulmonary hypertension has been revised with changes including the substitution of the term idiopathic for primary PAH and an expanded list of conditions felt to be associated with the development of PAH. Long-term follow-up studies have provided better information on prognosis and expected outcomes with treatment, with particularly valuable data on reassessment of prognosis after treatment with epoprostenol. Combination therapy is more frequently being used, and limited data on novel therapies such as stem cell transplantation have been published. The purpose of this review is to describe the current state of evidence for the diagnosis, prognosis, and treatment of the patient with PAH. |
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| AbstractList | Pulmonary Arterial Hypertension Kelly M. Chin, Lewis J. Rubin Significant advances in the treatment of pulmonary arterial hypertension have occurred over the last 10 years, starting with the approval of epoprostenol in 1998, followed by the development of subcutaneous and inhaled prostacyclins, oral endothelin antagonists, and oral phosphodiesterase type-5 inhibitors. Combination therapy is more frequently being used, and limited data on novel therapies such as stem cell transplantation have been published. The purpose of this review is to describe the current state of evidence for the diagnosis, prognosis, and treatment of the patient with pulmonary arterial hypertension. Significant advances in the treatment of pulmonary arterial hypertension (PAH) have occurred over the last 10 years, starting with the approval of epoprostenol in 1998. Subsequently, multiple additional medications have received approval, including a subcutaneous prostacyclin, an inhaled prostacyclin, and oral medications in 2 separate classes. Over this same period, the classification of pulmonary hypertension has been revised with changes including the substitution of the term idiopathic for primary PAH and an expanded list of conditions felt to be associated with the development of PAH. Long-term follow-up studies have provided better information on prognosis and expected outcomes with treatment, with particularly valuable data on reassessment of prognosis after treatment with epoprostenol. Combination therapy is more frequently being used, and limited data on novel therapies such as stem cell transplantation have been published. The purpose of this review is to describe the current state of evidence for the diagnosis, prognosis, and treatment of the patient with PAH.Significant advances in the treatment of pulmonary arterial hypertension (PAH) have occurred over the last 10 years, starting with the approval of epoprostenol in 1998. Subsequently, multiple additional medications have received approval, including a subcutaneous prostacyclin, an inhaled prostacyclin, and oral medications in 2 separate classes. Over this same period, the classification of pulmonary hypertension has been revised with changes including the substitution of the term idiopathic for primary PAH and an expanded list of conditions felt to be associated with the development of PAH. Long-term follow-up studies have provided better information on prognosis and expected outcomes with treatment, with particularly valuable data on reassessment of prognosis after treatment with epoprostenol. Combination therapy is more frequently being used, and limited data on novel therapies such as stem cell transplantation have been published. The purpose of this review is to describe the current state of evidence for the diagnosis, prognosis, and treatment of the patient with PAH. Significant advances in the treatment of pulmonary arterial hypertension (PAH) have occurred over the last 10 years, starting with the approval of epoprostenol in 1998. Subsequently, multiple additional medications have received approval, including a subcutaneous prostacyclin, an inhaled prostacyclin, and oral medications in 2 separate classes. Over this same period, the classification of pulmonary hypertension has been revised with changes including the substitution of the term idiopathic for primary PAH and an expanded list of conditions felt to be associated with the development of PAH. Long-term follow-up studies have provided better information on prognosis and expected outcomes with treatment, with particularly valuable data on reassessment of prognosis after treatment with epoprostenol. Combination therapy is more frequently being used, and limited data on novel therapies such as stem cell transplantation have been published. The purpose of this review is to describe the current state of evidence for the diagnosis, prognosis, and treatment of the patient with PAH. Pulmonary Arterial Hypertension Kelly M. Chin, Lewis J. Rubin Significant advances in the treatment of pulmonary arterial hypertension have occurred over the last 10 years, starting with the approval of epoprostenol in 1998, followed by the development of subcutaneous and inhaled prostacyclins, oral endothelin antagonists, and oral phosphodiesterase type-5 inhibitors. Combination therapy is more frequently being used, and limited data on novel therapies such as stem cell transplantation have been published. The purpose of this review is to describe the current state of evidence for the diagnosis, prognosis, and treatment of the patient with pulmonary arterial hypertension. Significant advances in the treatment of pulmonary arterial hypertension (PAH) have occurred over the last 10 years, starting with the approval of epoprostenol in 1998. Subsequently, multiple additional medications have received approval, including a subcutaneous prostacyclin, an inhaled prostacyclin, and oral medications in 2 separate classes. Over this same period, the classification of pulmonary hypertension has been revised with changes including the substitution of the term idiopathic for primary PAH and an expanded list of conditions felt to be associated with the development of PAH. Long-term follow-up studies have provided better information on prognosis and expected outcomes with treatment, with particularly valuable data on reassessment of prognosis after treatment with epoprostenol. Combination therapy is more frequently being used, and limited data on novel therapies such as stem cell transplantation have been published. The purpose of this review is to describe the current state of evidence for the diagnosis, prognosis, and treatment of the patient with PAH. |
| Author | Rubin, Lewis J. Chin, Kelly M. |
| Author_xml | – sequence: 1 givenname: Kelly M. surname: Chin fullname: Chin, Kelly M. email: Kelly.Chin@utsouthwestern.edu organization: Department of Internal Medicine, Division of Pulmonary and Critical Care, University of Texas Southwestern Medical Center, Dallas, Texas – sequence: 2 givenname: Lewis J. surname: Rubin fullname: Rubin, Lewis J. organization: Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of California, San Diego, California |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20267386$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/18420094$$D View this record in MEDLINE/PubMed |
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| Issue | 16 |
| Keywords | CHF NO BMPR HIV RV PAH bone morphogenetic protein receptor right ventricle/ventricular nitric oxide human immunodeficiency virus congestive heart failure pulmonary arterial hypertension Cardiovascular disease Circulatory system Cardiology Respiratory disease Artery Pulmonary hypertension |
| Language | English |
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| Snippet | Pulmonary Arterial Hypertension
Kelly M. Chin, Lewis J. Rubin
Significant advances in the treatment of pulmonary arterial hypertension have occurred over the... Pulmonary Arterial Hypertension Kelly M. Chin, Lewis J. Rubin Significant advances in the treatment of pulmonary arterial hypertension have occurred over the... Significant advances in the treatment of pulmonary arterial hypertension (PAH) have occurred over the last 10 years, starting with the approval of epoprostenol... |
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| SubjectTerms | Algorithms Antihypertensive Agents - therapeutic use Biological and medical sciences Cardiology Cardiology. Vascular system Cardiovascular Disease Progression Drug therapy Humans Hypertension, Pulmonary - classification Hypertension, Pulmonary - complications Hypertension, Pulmonary - drug therapy Internal Medicine Medical sciences Muscular system Mutation Nitric oxide Pneumology Prognosis Pulmonary Artery - pathology Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases Risk Factors Rodents |
| Title | Pulmonary Arterial Hypertension |
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