Saponins from Chinese Medicinal Plant, Hemsleya graciliflora (Cucurbitaceae)

• Published in: Chemical & pharmaceutical bulletin Vol. 38; no. 5; pp. 1320 - 1322
• Main Authors: TANAKA, Osamu, KASAI, Ryoji, TANAKA, Takahiro, ZHOU, Jun, NIE, Rui-Lin, MIYAKOSHI, Masazumi
• Format: Journal Article
• Language: English
• Published: Tokyo The Pharmaceutical Society of Japan 1990; Maruzen; Japan Science and Technology Agency
• Subjects: Biological and medical sciences; chikusetsusaponin; Chinese medicinal plant; cucurbitane-type triterpene; General pharmacology; Hemsleya graciliflora : Cucurbitaceae; hemsloside; Medical sciences; oleanolic acid glucuronide; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; saponin; Molecular structure; Pharmacognosy; Cucurbitaceae; Medicinal plant; Saponin; Folk medicine; Asia; Dicotyledones; China; Angiospermae; Plant origin; Rhizome; Isolation; Spermatophyta
• ISSN: 0009-2363; 1347-5223
• DOI: 10.1248/cpb.38.1320

From rhizomes of a Chinese cucurbitaceous medicinal plant, Hemsleya graciliflora, eight oleanolic glucuronide saponins were isolated together with three known cucurbitane-type triterpenes, dihydrocucurbitacin F, 25-O-acetyl-dihydrocucurbitacin F and its 2-O-β-glucosides. Of these saponins, six were known and identified as β-D-glucosyl ester of oleanolic acid, chikusetsusaponins IV a and V and hemslosides Ma1, Ma3 and H1. Structures of two new saponins called hemslosides G1 and G2 were elucidated as β-gentiobiosyl esters of oleanolic acid 3-O-α-L-arabinopyranosyl-(1→3)-β-D-glucuronide and oleanolic acid 3-O-β-D-glucopyranosyl-(1→2)-β-D-glucuronide, respectively.