Spike protein recognition of mammalian ACE2 predicts the host range and an optimized ACE2 for SARS-CoV-2 infection

• Published in: Biochemical and biophysical research communications Vol. 526; no. 1; pp. 165 - 169
• Main Authors: Luan, Junwen, Lu, Yue, Jin, Xiaolu, Zhang, Leiliang
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 21.05.2020
• Subjects: ACE2; Amino Acid Sequence; Angiotensin-Converting Enzyme 2; Animals; Betacoronavirus - physiology; Coronavirus Infections - metabolism; Coronavirus Infections - transmission; Coronavirus Infections - virology; COVID-19; COVID-19 infection; Cricetulus griseus; dogs; Host range; Humans; Mammals - classification; Mammals - metabolism; Models, Molecular; Pandemics; Peptidyl-Dipeptidase A - chemistry; Peptidyl-Dipeptidase A - metabolism; Pneumonia, Viral - metabolism; Pneumonia, Viral - transmission; Pneumonia, Viral - virology; public health; SARS-CoV-2; Sequence Alignment; Severe acute respiratory syndrome coronavirus 2; Spike Glycoprotein, Coronavirus - chemistry; Spike Glycoprotein, Coronavirus - metabolism; Spike protein; Structure; Viral Tropism; Spike protein; E; JTT; M; N; COVID-19; ACE2; SARS-CoV-2; S; RBD; Host range; SARSr-CoV; Structure; RBM

SARS-CoV-2 causes the recent global COVID-19 public health emergency. ACE2 is the receptor for both SARS-CoV-2 and SARS-CoV. To predict the potential host range of SARS-CoV-2, we analyzed the key residues of ACE2 for recognizing S protein. We found that most of the selected mammals including pets (d...