Optimizing vs. Matching: Response Strategy in a Probabilistic Learning Task is associated with Negative Symptoms of Schizophrenia

• Published in: Schizophrenia research Vol. 127; no. 1-3; pp. 215 - 222
• Main Authors: Kasanova, Zuzana, Waltz, James A., Strauss, Gregory P., Frank, Michael J., Gold, James M.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01.04.2011; Elsevier
• Subjects: Adult; Adult and adolescent clinical studies; Behavioral Symptoms - etiology; Biological and medical sciences; Choice Behavior - physiology; Exploration; Female; Humans; Male; Matching; Medical sciences; Middle Aged; Negative Symptoms; Neuropsychological Tests; Probability Learning; Probability Learning Task; Psychiatric Status Rating Scales; Psychiatry; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychoses; Reinforcement Learning; Schizophrenia; Schizophrenia - complications; Schizophrenic Psychology; Probability Learning Task; Matching; Schizophrenia; Reinforcement Learning; Exploration; Negative Symptoms; Psychosis; Human; Acquisition process; Negative symptom; Reinforcement learning; Strategy; Probability learning
• DOI: 10.1016/j.schres.2010.12.003
• ISSN: 0920-9964; 1573-2509

Previous research indicates that behavioral performance in simple probability learning tasks can be organized into response strategy classifications that are thought to predict important personal characteristics and individual differences. Typically, relatively small proportion of subjects can be identified as optimizers for effectively exploiting the environment and choosing the more rewarding stimulus nearly all of the time. In contrast, the vast majority of subjects behaves sub-optimally and adopts the matching or super-matching strategy, apportioning their responses in a way that matches or slightly exceeds the probabilities of reinforcement. In the present study, we administered a two-choice probability learning paradigm to 51 individuals with schizophrenia (SZ) and 29 healthy controls (NC) to examine whether there are differences in the proportion of subjects falling into these response strategy classifications, and to determine whether task performance is differentially associated with symptom severity and neuropsychological functioning. Although the sample of SZ patients did not differ from NC in overall rate of learning or end performance, significant clinical differences emerged when patients were divided into optimizing, super-matching and matching subgroups based upon task performance. Patients classified as optimizers, who adopted the most advantageous learning strategy, exhibited higher levels of positive and negative symptoms than their matching and super-matching counterparts. Importantly, when both positive and negative symptoms were considered together, only negative symptom severity was a significant predictor of whether a subject would behave optimally, with each one standard deviation increase in negative symptoms increasing the odds of a patient being an optimizer by as much as 80%. These data provide a rare example of a greater clinical impairment being associated with better behavioral performance.