common pumiliotoxin from poison frogs exhibits enantioselective toxicity against mosquitoes

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 103; no. 47; pp. 17818 - 17821
• Main Authors: Weldon, P.J, Kramer, M, Gordon, S, Spande, T.F, Daly, J.W
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 21.11.2006; National Acad Sciences
• Subjects: Aedes aegypti; Alkaloids; Alkaloids - chemistry; Alkaloids - toxicity; Amphibian Venoms - chemistry; Amphibian Venoms - toxicity; Amphibians; Animals; Anura; Arthropoda; Biological Sciences; Culicidae - drug effects; Defense mechanisms; Dendrobatidae; Dosage; Dose-Response Relationship, Drug; Enantiomers; Female; Frogs; Indolizines - chemistry; Indolizines - therapeutic use; insecticidal properties; Mice; Molecular Conformation; Molecular Structure; Mosquitoes; Mosquitos; P branes; Pipettes; pumiliotoxin; Skin; Toxicity; Toxins

Neotropical poison frogs (Dendrobatidae) contain a variety of lipophilic alkaloids in their diffusely distributed cutaneous glands, including a major class of compounds known as pumiliotoxins. Pumiliotoxins are highly toxic and are believed to protect frogs against predators. Their potential activit...