A Unifying Theory of Branching Morphogenesis

• Published in: Cell Vol. 171; no. 1; pp. 242 - 255.e27
• Main Authors: Hannezo, Edouard, Scheele, Colinda L.G.J., Moad, Mohammad, Drogo, Nicholas, Heer, Rakesh, Sampogna, Rosemary V., van Rheenen, Jacco, Simons, Benjamin D.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 21.09.2017; Cell Press
• Subjects: Animals; branching and annihilating random walks; branching morphogenesis; epithelium; Female; Humans; kidney; Kidney - embryology; Kidney - growth & development; kidneys; Male; mammary gland; mammary glands; Mammary Glands, Human - embryology; Mammary Glands, Human - growth & development; mathematical modeling; Mice; Models, Biological; Morphogenesis; prostate; Prostate - embryology; Prostate - growth & development; quantitative analysis; self-organization; signal transduction; Theory; kidney; self-organization; mathematical modeling; branching and annihilating random walks; prostate; mammary gland; branching morphogenesis
• ISSN: 0092-8674; 1097-4172; 1097-4172
• DOI: 10.1016/j.cell.2017.08.026

The morphogenesis of branched organs remains a subject of abiding interest. Although much is known about the underlying signaling pathways, it remains unclear how macroscopic features of branched organs, including their size, network topology, and spatial patterning, are encoded. Here, we show that,...