Cis-regulatory organization of the Pax6 gene in the ascidian Ciona intestinalis

• Published in: Developmental biology Vol. 317; no. 2; pp. 649 - 659
• Main Authors: Irvine, Steven Q., Fonseca, Vera C., Zompa, Michael A., Antony, Rajee
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.05.2008
• Subjects: Animals; Ciona intestinalis; Ciona intestinalis - genetics; Drosophila; Electroporation; Enhancers; Eye Proteins - genetics; Eye Proteins - metabolism; Gene Expression Regulation - genetics; Homeodomain Proteins - genetics; Homeodomain Proteins - metabolism; In Situ Hybridization; Nervous System - embryology; Nervous System - metabolism; Paired Box Transcription Factors - genetics; Paired Box Transcription Factors - metabolism; PAX6 Transcription Factor; Photoreceptor Cells, Invertebrate - embryology; Photoreceptor Cells, Invertebrate - metabolism; Regulatory Sequences, Nucleic Acid - genetics; Repressor Proteins - genetics; Repressor Proteins - metabolism; Transcriptional regulator; Transgenes - genetics; Tunicate; Urochordate; Transcriptional regulator; Enhancers; Urochordate; Tunicate

The Pax6 gene has attracted intense research interest due to its apparently important role in the development of eyes and the central nervous system (CNS) in many animal groups. Pax6 is also of interest for comparative genomics since it has not been duplicated in tetrapods, making for a direct ortho...