Antibiofilm and antivirulence potential of silver nanoparticles against multidrug-resistant Acinetobacter baumannii
We aimed to isolate Acinetobacter baumannii ( A. baumannii ) from wound infections, determine their resistance and virulence profile, and assess the impact of Silver nanoparticles (AgNPs) on the bacterial growth, virulence and biofilm-related gene expression. AgNPs were synthesized and characterized...
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| Published in | Scientific reports Vol. 11; no. 1; pp. 10751 - 11 |
|---|---|
| Main Authors | , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Nature Publishing Group UK
24.05.2021
Nature Publishing Group Nature Portfolio |
| Subjects | |
| Online Access | Get full text |
| ISSN | 2045-2322 2045-2322 |
| DOI | 10.1038/s41598-021-90208-4 |
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| Abstract | We aimed to isolate
Acinetobacter baumannii
(
A. baumannii
) from wound infections, determine their resistance and virulence profile, and assess the impact of Silver nanoparticles (AgNPs) on the bacterial growth, virulence and biofilm-related gene expression. AgNPs were synthesized and characterized using TEM, XRD and FTIR spectroscopy.
A. baumannii
(n = 200) were isolated and identified. Resistance pattern was determined and virulence genes (
afa/draBC, cnf1, cnf2, csgA, cvaC, fimH, fyuA, ibeA, iutA, kpsMT II, PAI, papC, PapG II, III, sfa/focDE
and
traT)
were screened using PCR. Biofilm formation was evaluated using Microtiter plate method. Then, the antimicrobial activity of AgNPs was evaluated by the well-diffusion method, growth kinetics and MIC determination. Inhibition of biofilm formation and the ability to disperse biofilms in exposure to AgNPs were evaluated. The effect of AgNPs on the expression of virulence and biofilm-related genes (
bap, OmpA, abaI, csuA/B, A1S_2091, A1S_1510, A1S_0690, A1S_0114
) were estimated using QRT-PCR. In vitro infection model for analyzing the antibacterial activity of AgNPs was done using a co-culture infection model of
A. baumannii
with human fibroblast skin cell line HFF-1 or Vero cell lines.
A. baumannii
had high level of resistance to antibiotics. Most of the isolates harbored the
fimH
,
afa/draBC
,
cnf1
,
csgA
and
cnf2,
and the majority of
A. baumannii
produced strong biofilms. AgNPs inhibited the growth of
A. baumannii
efficiently with MIC ranging from 4 to 25 µg/ml.
A. baumannii
showed a reduced growth rate in the presence of AgNPs. The inhibitory activity and the anti-biofilm activity of AgNPs were more pronounced against the weak biofilm producers. Moreover, AgNPs decreased the expression of
kpsMII
,
afa/draBC,bap, OmpA,
and
csuA/B
genes. The in vitro infection model revealed a significant antibacterial activity of AgNPs against extracellular and intracellular
A. baumannii
. AgNPs highly interrupted bacterial multiplication and biofilm formation. AgNPs downregulated the transcription level of important virulence and biofilm-related genes. Our findings provide an additional step towards understanding the mechanisms by which sliver nanoparticles interfere with the microbial spread and persistence. |
|---|---|
| AbstractList | We aimed to isolate
Acinetobacter baumannii
(
A. baumannii
) from wound infections, determine their resistance and virulence profile, and assess the impact of Silver nanoparticles (AgNPs) on the bacterial growth, virulence and biofilm-related gene expression. AgNPs were synthesized and characterized using TEM, XRD and FTIR spectroscopy.
A. baumannii
(n = 200) were isolated and identified. Resistance pattern was determined and virulence genes (
afa/draBC, cnf1, cnf2, csgA, cvaC, fimH, fyuA, ibeA, iutA, kpsMT II, PAI, papC, PapG II, III, sfa/focDE
and
traT)
were screened using PCR. Biofilm formation was evaluated using Microtiter plate method. Then, the antimicrobial activity of AgNPs was evaluated by the well-diffusion method, growth kinetics and MIC determination. Inhibition of biofilm formation and the ability to disperse biofilms in exposure to AgNPs were evaluated. The effect of AgNPs on the expression of virulence and biofilm-related genes (
bap, OmpA, abaI, csuA/B, A1S_2091, A1S_1510, A1S_0690, A1S_0114
) were estimated using QRT-PCR. In vitro infection model for analyzing the antibacterial activity of AgNPs was done using a co-culture infection model of
A. baumannii
with human fibroblast skin cell line HFF-1 or Vero cell lines.
A. baumannii
had high level of resistance to antibiotics. Most of the isolates harbored the
fimH
,
afa/draBC
,
cnf1
,
csgA
and
cnf2,
and the majority of
A. baumannii
produced strong biofilms. AgNPs inhibited the growth of
A. baumannii
efficiently with MIC ranging from 4 to 25 µg/ml.
A. baumannii
showed a reduced growth rate in the presence of AgNPs. The inhibitory activity and the anti-biofilm activity of AgNPs were more pronounced against the weak biofilm producers. Moreover, AgNPs decreased the expression of
kpsMII
,
afa/draBC,bap, OmpA,
and
csuA/B
genes. The in vitro infection model revealed a significant antibacterial activity of AgNPs against extracellular and intracellular
A. baumannii
. AgNPs highly interrupted bacterial multiplication and biofilm formation. AgNPs downregulated the transcription level of important virulence and biofilm-related genes. Our findings provide an additional step towards understanding the mechanisms by which sliver nanoparticles interfere with the microbial spread and persistence. We aimed to isolate Acinetobacter baumannii (A. baumannii) from wound infections, determine their resistance and virulence profile, and assess the impact of Silver nanoparticles (AgNPs) on the bacterial growth, virulence and biofilm-related gene expression. AgNPs were synthesized and characterized using TEM, XRD and FTIR spectroscopy. A. baumannii (n = 200) were isolated and identified. Resistance pattern was determined and virulence genes (afa/draBC, cnf1, cnf2, csgA, cvaC, fimH, fyuA, ibeA, iutA, kpsMT II, PAI, papC, PapG II, III, sfa/focDE and traT) were screened using PCR. Biofilm formation was evaluated using Microtiter plate method. Then, the antimicrobial activity of AgNPs was evaluated by the well-diffusion method, growth kinetics and MIC determination. Inhibition of biofilm formation and the ability to disperse biofilms in exposure to AgNPs were evaluated. The effect of AgNPs on the expression of virulence and biofilm-related genes (bap, OmpA, abaI, csuA/B, A1S_2091, A1S_1510, A1S_0690, A1S_0114) were estimated using QRT-PCR. In vitro infection model for analyzing the antibacterial activity of AgNPs was done using a co-culture infection model of A. baumannii with human fibroblast skin cell line HFF-1 or Vero cell lines. A. baumannii had high level of resistance to antibiotics. Most of the isolates harbored the fimH, afa/draBC, cnf1, csgA and cnf2, and the majority of A. baumannii produced strong biofilms. AgNPs inhibited the growth of A. baumannii efficiently with MIC ranging from 4 to 25 µg/ml. A. baumannii showed a reduced growth rate in the presence of AgNPs. The inhibitory activity and the anti-biofilm activity of AgNPs were more pronounced against the weak biofilm producers. Moreover, AgNPs decreased the expression of kpsMII , afa/draBC,bap, OmpA, and csuA/B genes. The in vitro infection model revealed a significant antibacterial activity of AgNPs against extracellular and intracellular A. baumannii. AgNPs highly interrupted bacterial multiplication and biofilm formation. AgNPs downregulated the transcription level of important virulence and biofilm-related genes. Our findings provide an additional step towards understanding the mechanisms by which sliver nanoparticles interfere with the microbial spread and persistence.We aimed to isolate Acinetobacter baumannii (A. baumannii) from wound infections, determine their resistance and virulence profile, and assess the impact of Silver nanoparticles (AgNPs) on the bacterial growth, virulence and biofilm-related gene expression. AgNPs were synthesized and characterized using TEM, XRD and FTIR spectroscopy. A. baumannii (n = 200) were isolated and identified. Resistance pattern was determined and virulence genes (afa/draBC, cnf1, cnf2, csgA, cvaC, fimH, fyuA, ibeA, iutA, kpsMT II, PAI, papC, PapG II, III, sfa/focDE and traT) were screened using PCR. Biofilm formation was evaluated using Microtiter plate method. Then, the antimicrobial activity of AgNPs was evaluated by the well-diffusion method, growth kinetics and MIC determination. Inhibition of biofilm formation and the ability to disperse biofilms in exposure to AgNPs were evaluated. The effect of AgNPs on the expression of virulence and biofilm-related genes (bap, OmpA, abaI, csuA/B, A1S_2091, A1S_1510, A1S_0690, A1S_0114) were estimated using QRT-PCR. In vitro infection model for analyzing the antibacterial activity of AgNPs was done using a co-culture infection model of A. baumannii with human fibroblast skin cell line HFF-1 or Vero cell lines. A. baumannii had high level of resistance to antibiotics. Most of the isolates harbored the fimH, afa/draBC, cnf1, csgA and cnf2, and the majority of A. baumannii produced strong biofilms. AgNPs inhibited the growth of A. baumannii efficiently with MIC ranging from 4 to 25 µg/ml. A. baumannii showed a reduced growth rate in the presence of AgNPs. The inhibitory activity and the anti-biofilm activity of AgNPs were more pronounced against the weak biofilm producers. Moreover, AgNPs decreased the expression of kpsMII , afa/draBC,bap, OmpA, and csuA/B genes. The in vitro infection model revealed a significant antibacterial activity of AgNPs against extracellular and intracellular A. baumannii. AgNPs highly interrupted bacterial multiplication and biofilm formation. AgNPs downregulated the transcription level of important virulence and biofilm-related genes. Our findings provide an additional step towards understanding the mechanisms by which sliver nanoparticles interfere with the microbial spread and persistence. We aimed to isolate Acinetobacter baumannii (A. baumannii) from wound infections, determine their resistance and virulence profile, and assess the impact of Silver nanoparticles (AgNPs) on the bacterial growth, virulence and biofilm-related gene expression. AgNPs were synthesized and characterized using TEM, XRD and FTIR spectroscopy. A. baumannii (n = 200) were isolated and identified. Resistance pattern was determined and virulence genes (afa/draBC, cnf1, cnf2, csgA, cvaC, fimH, fyuA, ibeA, iutA, kpsMT II, PAI, papC, PapG II, III, sfa/focDE and traT) were screened using PCR. Biofilm formation was evaluated using Microtiter plate method. Then, the antimicrobial activity of AgNPs was evaluated by the well-diffusion method, growth kinetics and MIC determination. Inhibition of biofilm formation and the ability to disperse biofilms in exposure to AgNPs were evaluated. The effect of AgNPs on the expression of virulence and biofilm-related genes (bap, OmpA, abaI, csuA/B, A1S_2091, A1S_1510, A1S_0690, A1S_0114) were estimated using QRT-PCR. In vitro infection model for analyzing the antibacterial activity of AgNPs was done using a co-culture infection model of A. baumannii with human fibroblast skin cell line HFF-1 or Vero cell lines. A. baumannii had high level of resistance to antibiotics. Most of the isolates harbored the fimH, afa/draBC, cnf1, csgA and cnf2, and the majority of A. baumannii produced strong biofilms. AgNPs inhibited the growth of A. baumannii efficiently with MIC ranging from 4 to 25 µg/ml. A. baumannii showed a reduced growth rate in the presence of AgNPs. The inhibitory activity and the anti-biofilm activity of AgNPs were more pronounced against the weak biofilm producers. Moreover, AgNPs decreased the expression of kpsMII , afa/draBC,bap, OmpA, and csuA/B genes. The in vitro infection model revealed a significant antibacterial activity of AgNPs against extracellular and intracellular A. baumannii. AgNPs highly interrupted bacterial multiplication and biofilm formation. AgNPs downregulated the transcription level of important virulence and biofilm-related genes. Our findings provide an additional step towards understanding the mechanisms by which sliver nanoparticles interfere with the microbial spread and persistence. Abstract We aimed to isolate Acinetobacter baumannii (A. baumannii) from wound infections, determine their resistance and virulence profile, and assess the impact of Silver nanoparticles (AgNPs) on the bacterial growth, virulence and biofilm-related gene expression. AgNPs were synthesized and characterized using TEM, XRD and FTIR spectroscopy. A. baumannii (n = 200) were isolated and identified. Resistance pattern was determined and virulence genes (afa/draBC, cnf1, cnf2, csgA, cvaC, fimH, fyuA, ibeA, iutA, kpsMT II, PAI, papC, PapG II, III, sfa/focDE and traT) were screened using PCR. Biofilm formation was evaluated using Microtiter plate method. Then, the antimicrobial activity of AgNPs was evaluated by the well-diffusion method, growth kinetics and MIC determination. Inhibition of biofilm formation and the ability to disperse biofilms in exposure to AgNPs were evaluated. The effect of AgNPs on the expression of virulence and biofilm-related genes (bap, OmpA, abaI, csuA/B, A1S_2091, A1S_1510, A1S_0690, A1S_0114) were estimated using QRT-PCR. In vitro infection model for analyzing the antibacterial activity of AgNPs was done using a co-culture infection model of A. baumannii with human fibroblast skin cell line HFF-1 or Vero cell lines. A. baumannii had high level of resistance to antibiotics. Most of the isolates harbored the fimH, afa/draBC, cnf1, csgA and cnf2, and the majority of A. baumannii produced strong biofilms. AgNPs inhibited the growth of A. baumannii efficiently with MIC ranging from 4 to 25 µg/ml. A. baumannii showed a reduced growth rate in the presence of AgNPs. The inhibitory activity and the anti-biofilm activity of AgNPs were more pronounced against the weak biofilm producers. Moreover, AgNPs decreased the expression of kpsMII , afa/draBC,bap, OmpA, and csuA/B genes. The in vitro infection model revealed a significant antibacterial activity of AgNPs against extracellular and intracellular A. baumannii. AgNPs highly interrupted bacterial multiplication and biofilm formation. AgNPs downregulated the transcription level of important virulence and biofilm-related genes. Our findings provide an additional step towards understanding the mechanisms by which sliver nanoparticles interfere with the microbial spread and persistence. |
| ArticleNumber | 10751 |
| Author | Hetta, Helal F. Elkady, Azza A. Mohamed, Nahed A. Algammal, Abdelazeem M. Khazaal, Saba Saadoon Abbas, Suhad Ellah, Noura H. Abd Abd-ellatief, Rasha B. Batiha, Gaber El-Saber Suhail, Ahmed El-Mokhtar, Mohamed A. Ahmed, Esraa A. El-Masry, Eman A. Al-Kadmy, Israa M. S. |
| Author_xml | – sequence: 1 givenname: Helal F. surname: Hetta fullname: Hetta, Helal F. email: helalhetta@aun.edu.eg organization: Department of Medical Microbiology and Immunology, Faculty of Medicine, Assiut University, Department of Internal Medicine, University of Cincinnati College of Medicine – sequence: 2 givenname: Israa M. S. surname: Al-Kadmy fullname: Al-Kadmy, Israa M. S. email: israa.al-kadmy@plymouth.ac.uk organization: Branch of Biotechnology, Department of Biology, College of Science, AL-Mustansiriyah University, Faculty of Science and Engineering, School of Engineering, University of Plymouth – sequence: 3 givenname: Saba Saadoon surname: Khazaal fullname: Khazaal, Saba Saadoon organization: Branch of Biotechnology, Department of Biology, College of Science, AL-Mustansiriyah University – sequence: 4 givenname: Suhad surname: Abbas fullname: Abbas, Suhad organization: Branch of Biotechnology, Department of Biology, College of Science, AL-Mustansiriyah University – sequence: 5 givenname: Ahmed surname: Suhail fullname: Suhail, Ahmed organization: Wolfson Nanomaterials and Devices Laboratory, School of Computing, Electronics and Mathematics, Faculty of Science and Engineering, Plymouth University – sequence: 6 givenname: Mohamed A. surname: El-Mokhtar fullname: El-Mokhtar, Mohamed A. organization: Department of Medical Microbiology and Immunology, Faculty of Medicine, Assiut University – sequence: 7 givenname: Noura H. Abd surname: Ellah fullname: Ellah, Noura H. Abd organization: Department of Pharmaceutics, Faculty of Pharmacy, Assiut University – sequence: 8 givenname: Esraa A. surname: Ahmed fullname: Ahmed, Esraa A. organization: Department of Pharmacology, Faculty of Medicine, Assiut University, Centre of Excellence in Environmental Studies (CEES), King Abdulaziz University – sequence: 9 givenname: Rasha B. surname: Abd-ellatief fullname: Abd-ellatief, Rasha B. organization: Department of Pharmacology, Faculty of Medicine, Assiut University – sequence: 10 givenname: Eman A. surname: El-Masry fullname: El-Masry, Eman A. organization: Microbiology and Immunology Unit, Department of Pathology, College of Medicine, Jouf University, Department of Medical Microbiology and Immunology, College of Medicine, Menoufia University – sequence: 11 givenname: Gaber El-Saber surname: Batiha fullname: Batiha, Gaber El-Saber organization: Department of Pharmacology and Therapeutics, Faculty of Veterinary Medicines, Damanhour University – sequence: 12 givenname: Azza A. surname: Elkady fullname: Elkady, Azza A. organization: Sohag University Medical Administration, Sohag University – sequence: 13 givenname: Nahed A. surname: Mohamed fullname: Mohamed, Nahed A. organization: Department of Medical Biochemistry, Faculty of Medicine, Assiut University – sequence: 14 givenname: Abdelazeem M. surname: Algammal fullname: Algammal, Abdelazeem M. organization: Department of Bacteriology, Immunology, and Mycology, Faculty of Veterinary Medicine, Suez Canal University |
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| ContentType | Journal Article |
| Copyright | The Author(s) 2021 The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
| Copyright_xml | – notice: The Author(s) 2021 – notice: The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
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| DOI | 10.1038/s41598-021-90208-4 |
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| Snippet | We aimed to isolate
Acinetobacter baumannii
(
A. baumannii
) from wound infections, determine their resistance and virulence profile, and assess the impact of... We aimed to isolate Acinetobacter baumannii (A. baumannii) from wound infections, determine their resistance and virulence profile, and assess the impact of... Abstract We aimed to isolate Acinetobacter baumannii (A. baumannii) from wound infections, determine their resistance and virulence profile, and assess the... |
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| SubjectTerms | 631/326 692/420 Acinetobacter baumannii Antibacterial activity Antibiotics Antimicrobial activity Biofilms Cell culture Cell lines Drug resistance Gene expression Growth kinetics Growth rate Humanities and Social Sciences Infections Minimum inhibitory concentration multidisciplinary Multidrug resistance Multidrug resistant organisms Nanoparticles Science Science (multidisciplinary) Silver Transcription Virulence |
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| Title | Antibiofilm and antivirulence potential of silver nanoparticles against multidrug-resistant Acinetobacter baumannii |
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