Protoporphyrin IX (PpIX) Fluorescence during Meningioma Surgery: Correlations with Histological Findings and Expression of Heme Pathway Molecules

• Published in: Cancers Vol. 15; no. 1; p. 304
• Main Authors: Spille, Dorothee C, Bunk, Eva C, Thomas, Christian, Özdemir, Zeynep, Wagner, Andrea, Akkurt, Burak H, Mannil, Manoj, Paulus, Werner, Grauer, Oliver M, Stummer, Walter, Senner, Volker, Brokinkel, Benjamin
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.01.2023; MDPI
• Subjects: 5-aminolevulinic acid; ABCB6; ABCG2; Biosynthesis; Bone tumors; Brain cancer; Care and treatment; CPOX; Ectopic expression; Enzymes; FECH; Fluorescence; Gene expression; Genetic aspects; Health aspects; Heme; Immunohistochemistry; Light; Manufacturers; Meningioma; Metabolism; Methods; Microscopy; Neuropathology; Optical properties; Patients; Porphyrins; Protoporphyrin; Protoporphyrin IX; Surgery; Tumors; Visualization; Germany; meningioma; ABCB6; FECH; fluorescence; CPOX; protoporphyrin; 5-aminolevulinic acid; ABCG2

Background: The usefulness of 5-ALA-mediated fluorescence-guided resection (FGR) in meningiomas is controversial, and information on the molecular background of fluorescence is sparse. Methods: Specimens obtained during 44 FGRs of intracranial meningiomas were analyzed for the presence of tumor tiss...