Acidic milieu augments the expression of hepcidin, the central regulator of iron homeostasis

• Published in: International journal of hematology Vol. 96; no. 6; pp. 701 - 709
• Main Authors: Mizumoto, Chisaki, Kawabata, Hiroshi, Uchiyama, Tatsuki, Sakamoto, Soichiro, Kanda, Junya, Tomosugi, Naohisa, Takaori-Kondo, Akifumi
• Format: Journal Article
• Language: English
• Published: Japan Springer Japan 01.12.2012; Springer; Springer Nature B.V
• Subjects: Acidosis; Acids - pharmacology; Anemia; Anemias. Hemoglobinopathies; Antimicrobial Cationic Peptides - biosynthesis; Antimicrobial Cationic Peptides - genetics; Biological and medical sciences; Carbon Dioxide - pharmacology; Carcinoma, Hepatocellular - pathology; Cell Line, Tumor - drug effects; Cell Line, Tumor - metabolism; Cellular Microenvironment; Chronic kidney disease; Diseases of red blood cells; Gene Expression Regulation, Leukemic - drug effects; Gene Expression Regulation, Neoplastic - drug effects; Hematologic and hematopoietic diseases; Hematology; Hepcidin; Hepcidins; Homeostasis - drug effects; Humans; Hydrochloric Acid - pharmacology; Hydrogen-Ion Concentration; Iron - metabolism; Iron-Regulatory Proteins - biosynthesis; Iron-Regulatory Proteins - genetics; K562 Cells - drug effects; K562 Cells - metabolism; Kidneys; Lactic Acid - pharmacology; Liver Neoplasms - pathology; Medical sciences; Medicine; Medicine & Public Health; Neoplasm Proteins - biosynthesis; Neoplasm Proteins - genetics; Nephrology. Urinary tract diseases; Nephropathies. Renovascular diseases. Renal failure; Oncology; Original Article; Promoter Regions, Genetic; Renal failure; RNA, Messenger - biosynthesis; RNA, Neoplasm - biosynthesis; Up-Regulation - drug effects; Urinary system involvement in other diseases. Miscellaneous; Chronic kidney disease; Acidosis; Anemia; Hepcidin; Kidney disease; Urinary system disease; Hematology; Homeostasis; Hemopathy; Iron; Acid base balance disorder; Regulator; Metabolic disorder; Renal failure

Hepcidin is the central regulator of body iron homeostasis, and dysregulation of hepcidin expression causes various clinical disorders, such as anemia and hemochromatosis. Various stimuli, including iron load and interleukin-6, are involved in the regulation of hepcidin expression. We previously rep...