Multiphoton Imaging Can Be Used for Microscopic Examination of Intact Human Gastrointestinal Mucosa Ex Vivo

• Published in: Clinical gastroenterology and hepatology Vol. 6; no. 1; pp. 95 - 101
• Main Authors: Rogart, Jason N., Nagata, Jun, Loeser, Caroline S., Roorda, Robert D., Aslanian, Harry, Robert, Marie E., Zipfel, Warren R., Nathanson, Michael H.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2008
• Subjects: Animals; Biopsy; Feasibility Studies; Gastroenterology and Hepatology; Gastrointestinal Neoplasms - pathology; Humans; Intestinal Mucosa - pathology; Microscopy, Confocal; Microscopy, Fluorescence, Multiphoton; Rats; Staining and Labeling; Ti:S; SHG; MPM; CLSM; titanium:sapphire; confocal laser scanning microscopy; second harmonic generation; multiphoton microscopy

Background & Aims: The ability to observe cellular and subcellular detail during routine endoscopy is a major goal in the development of new endoscopic imaging techniques. Multiphoton microscopy, which relies on nonlinear infrared optical processes, has the potential to identify cellular details...